Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories DOI Open Access
C. J. Healy,

Aaron Frazier,

Stephen Kirsch

et al.

Published: July 26, 2024

Studies of psychedelic use in naturalistic and clinical settings have suggested safety mental health benefits for adults with histories childhood maltreatment. Acute psychological mechanisms that predict therapeutic this population, however, yet to be determined. Two common group – organized ceremonies raves or other electronic dance music events might facilitate effects because the unique psychosocial environments they comprise. This prospective, longitudinal study sought investigate 2 primary questions: first, whether maltreatment planning drugs intent at would see enduring after their experiences; second, subjective dimensions acute experience associated post-acute benefits. Eighty-five participants completed self-report measures month before, within days after, approximately months a planned ceremony rave assessing history; trauma symptoms, internalized (trait) shame, connectedness baseline follow-up; various experience. Mean scores posttraumatic stress disorder (PTSD) complex PTSD trait social connectedness, general significantly improved from 2-month follow-up (d = 0.73-1.12). Longitudinal changes outcomes correlated These findings implications regarding both potential benefit among as well action psychedelics.

Language: Английский

Serotonergic psychedelics as potential therapeutics for post-COVID-19 syndrome (or Long COVID): A comprehensive review DOI
Zhen Xuen Brandon Low, Shin Jie Yong, Hayam Ali AlRasheed

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111279 - 111279

Published: Feb. 1, 2025

Language: Английский

Citations

0
Relationality and Ethics in MDMA-Assisted Therapy DOI Creative Commons
Jamie Beachy,

Willa Hall,

Chantelle Thomas

et al.

The American Journal of Bioethics, Journal Year: 2025, Volume and Issue: 25(1), P. 67 - 71

Published: Jan. 2, 2025

Language: Английский

Citations

0
Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories DOI Creative Commons
C. J. Healy,

Aaron Frazier,

Stephen Kirsch

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111361 - 111361

Published: April 1, 2025

Studies of psychedelic use in naturalistic and clinical settings have suggested safety mental health benefits for adults with histories childhood maltreatment. Acute psychological mechanisms that predict therapeutic this population, however, yet to be determined. Two common group - organized ceremonies raves or other electronic dance music events might facilitate effects because the unique psychosocial environments they comprise. This prospective, longitudinal study sought investigate 2 primary questions: first, whether maltreatment planning drugs intent at would see enduring after their experiences; second, subjective dimensions acute experience associated lasting benefits. Eighty-five participants completed self-report measures month before, within days after, approximately months a planned ceremony rave assessing history; trauma symptoms, internalized (trait) shame, connectedness baseline follow-up; various experience. Mean scores posttraumatic stress disorder (PTSD) complex PTSD trait social connectedness, general significantly improved from 2-month follow-up (ds = 0.73-1.12). Longitudinal changes outcomes correlated These findings implications regarding both potential benefit among as well action psychedelics.

Language: Английский

Citations

0
Psilocybin Mitigates Behavioral Despair and Cognitive Impairment in Treatment-resistant Depression Model using Wistar Kyoto Rats DOI
Zitong Wang, Brett Robbins, R. L. Zhuang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Major depressive disorder (MDD) is a leading cause of disability that affects over 300 million people globally. Despite multiple antidepressant trials, approximately one-third MDD patients remain symptomatic, progressing to treatment-resistant depression (TRD). This persistence possibly due the multifaceted etiology TRD, encompassing biological, psychological, and environmental factors. Chronic stress, prevalent in modern life, significantly contributes mental health disorders complicates TRD treatment. study investigated psilocybin as potential treatment using diathesis-stress animal model. Twenty-two male Wistar-Kyoto (WKY) rats were divided into control stress groups, with group further subdivided receive either sham or early intervention. Behavioral assessments demonstrated significant sustained beneficial effect on behavioral despair cognitive impairment. Biochemical analyses revealed psilocybin-induced increases thyroid-stimulating hormone (TSH) levels without changes hypothalamic-pituitary-adrenal (HPA) axis. The ability counter stress-induced TSH reductions suggested may serve proxy marker therapeutic response, although its causal role mood regulation remains unclear. Additionally, following administration, cannabinoid receptor type I (CB1R) suggest modulation intervention component endocannabinoid system (ECS), though links unconfirmed antagonist studies. These findings highlight treat through targeting previously unexplored biological pathways.

Language: Английский

Citations

0
Trauma Under Psychedelics: MDMA Shows Protective Effects During the Peritraumatic Period DOI Creative Commons

Ophir Netzer,

Noa Magal, Yonatan Stern

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 31, 2024

Abstract Traumatic events (TEs) play a causal role in the etiology of psychopathologies such as depression and posttraumatic stress disorder (PTSD). Recent research has highlighted therapeutic potential psychoactive substances especially 3,4-methylenedioxymethamphetamine (MDMA), alleviating trauma symptoms chronic patients. However, little is known regarding consequences that acutely experienced under influence substances. Here we investigated acute experiences peritraumatic processing 657 survivors from high-casualty terror attack at Supernova music festival Israel on October 7 th , 2023. Data were collected four to twelve weeks following TE. Approximately two-thirds time TE, offering tragic unique natural experiment impact compounds TE processing. Our findings reveal individuals who while MDMA demonstrated significantly improved intermediate outcomes compared those other or no all. Specifically, group reported increased feelings social support, more interactions enhanced quality sleep during period, yielding reduced levels mental distress PTSD symptom severity. These novel suggest may carry protective effects into possibly mediated through reducing negative emotions elevating prosociality. turn mitigate development early psychopathology-related symptoms. Current preliminary results underscore need for further understanding cognitive physiological processes by which psychedelic intersect with recovery processes.

Language: Английский

Citations

3
Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm? DOI
Harriet de Wit, Friederike Holze, Katrin H. Preller

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(5), P. 460 - 461

Published: May 1, 2024

Language: Английский

Citations

0
Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories DOI Open Access
C. J. Healy,

Aaron Frazier,

Stephen Kirsch

et al.

Published: July 26, 2024

Studies of psychedelic use in naturalistic and clinical settings have suggested safety mental health benefits for adults with histories childhood maltreatment. Acute psychological mechanisms that predict therapeutic this population, however, yet to be determined. Two common group – organized ceremonies raves or other electronic dance music events might facilitate effects because the unique psychosocial environments they comprise. This prospective, longitudinal study sought investigate 2 primary questions: first, whether maltreatment planning drugs intent at would see enduring after their experiences; second, subjective dimensions acute experience associated post-acute benefits. Eighty-five participants completed self-report measures month before, within days after, approximately months a planned ceremony rave assessing history; trauma symptoms, internalized (trait) shame, connectedness baseline follow-up; various experience. Mean scores posttraumatic stress disorder (PTSD) complex PTSD trait social connectedness, general significantly improved from 2-month follow-up (d = 0.73-1.12). Longitudinal changes outcomes correlated These findings implications regarding both potential benefit among as well action psychedelics.

Language: Английский

Citations

0