Regional patterns of human cortex development correlate with underlying neurobiology

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 12, 2024

Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness and aging trajectories unfold along patterns molecular cellular organization, traceable from population-level to individual developmental trajectories. During childhood adolescence, cortex-wide spatial distributions dopaminergic receptors, inhibitory neurons, glial cell populations, brain-metabolic features explain up 50% variance associated with a lifespan model regional In contrast, modeled change during adulthood are best explained by cholinergic glutamatergic neurotransmitter receptor transporter distributions. These relationships supported gene expression translate longitudinal data 8000 adolescents, explaining 59% at cohort- 18% single-subject level. Integrating neurobiological atlases modeling population neuroimaging provides biologically meaningful path understand living humans.

Language: Английский

---

Regional patterns of human cortex development correlate with underlying neurobiology

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 5, 2023

Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness and aging trajectories unfold along patterns molecular cellular organization, traceable from population-level to individual developmental trajectories. During childhood adolescence, cortex-wide spatial distributions dopaminergic receptors, inhibitory neurons, glial cell populations, brain-metabolic features explain up 50% variance associated with a lifespan model regional In contrast, modeled change during adulthood are best explained by cholinergic glutamatergic neurotransmitter receptor transporter distributions. These relationships supported gene expression translate longitudinal data 8,000 adolescents, explaining 59% at cohort- 18% single-subject level. Integrating neurobiological atlases modeling population neuroimaging provides biologically meaningful path understand living humans.

Language: Английский

---

Understanding the Relationship of Functional and Neurochemical Brain Changes in Parkinson’s Disease: First Steps With Novel Neuroimaging Approaches

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(10), P. 969 - 970

Published: Oct. 1, 2024

Language: Английский

---