Auditory steady-state response deficits in Fragile X Syndrome implicate deficits in stimulus representation maintenance and GABAergic modulation

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Fragile X Syndrome (FXS) is a rare, neurodevelopmental disorder caused by mutation to the messenger ribonucleoprotein 1 ( Fmr1 ) gene and characterized sensory processing abnormalities sensitivities, including neural auditory oscillatory disruptions reduced entrainment chirp stimuli. The present study aims evaluate 40 Hz steady state response (ASSR) in FXS stimulus representation maintenance FXS. Adolescents adults (N = 67; 34 33 age, sex-matched typically developed controls (TDC)) completed task during electroencephalography (EEG). Time-frequency analyses using Morlet wavelets were intertrial phase coherence (ITC) event-related spectral perturbation (ERSP), characterization of transient sustained components ASSR. Both ITC p .003) ERSP .004) at for compared TDC. Interestingly, TDC exhibited significantly elevated early, component (100 - 400 ms) which both transition (650 3000 whereas consistently across ASSR suggesting ability mount response. Individuals with exhibit robust reductions magnitude temporal precision stimulus. may represent GABAergic modulation where overall reduction reflect excitatory/inhibitory balance between NMDA input.

Language: Английский

Unraveling Prefrontal Cortical Inhibitory Dynamics: A Novel Approach to Investigate GABAergic Function with TMS-EEG

Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Transcranial Magnetic Stimulation–Electroencephalography (TMS-EEG) in Neurosurgery: Unexplored Path Towards Personalized Brain Surgery

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1144 - 1144

Published: Dec. 9, 2024

Transcranial Magnetic Stimulation-Electroencephalography (TMS-EEG) is a non-operative technique that allows for magnetic cortical stimulation (TMS) and analysis of the electrical currents generated in brain (EEG). Despite regular utilization both techniques independently, little known about potential impact their combination neurosurgical practice.

Language: Английский