Brain Network Abnormalities in Obsessive–Compulsive Disorder: Insights from Edge Functional Connectivity Analysis DOI Creative Commons

Yong Xu,

H. MEI LIU,

Haiyan Liu

et al.

Behavioral Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 488 - 488

Published: April 8, 2025

Functional differences in key brain networks, including the dorsal attention network (DAN), control (CN), and default mode (DMN), have been identified individuals with obsessive–compulsive disorder (OCD). However, precise nature of these remains unclear. In this study, we further explored validated previous findings using a novel edge functional connectivity (eFC) approach, which enables more refined analysis interaction. By employing advanced method, sought to gain deeper insights into FC alterations that may underlie pathology OCD. We collected data during movie watching from 44 patients OCD 33 healthy controls (HCs). The two-sample t test was used assess entropy between DAN, CN, DMN groups. performed for potentially confounding variables ensure robustness findings. Significant were found HC Relative HCs, showed significantly reduced DAN increased CN DMN. decreased observed study be related core symptoms OCD, such as deficit, impaired cognitive control, self-referential thinking. These results provide valuable neurobiological mechanisms highlight potential biomarker disorder. Future research should explore relationship changes severity symptoms, well their implications development treatment strategies.

Language: Английский

Brain Network Abnormalities in Obsessive–Compulsive Disorder: Insights from Edge Functional Connectivity Analysis DOI Creative Commons

Yong Xu,

H. MEI LIU,

Haiyan Liu

et al.

Behavioral Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 488 - 488

Published: April 8, 2025

Functional differences in key brain networks, including the dorsal attention network (DAN), control (CN), and default mode (DMN), have been identified individuals with obsessive–compulsive disorder (OCD). However, precise nature of these remains unclear. In this study, we further explored validated previous findings using a novel edge functional connectivity (eFC) approach, which enables more refined analysis interaction. By employing advanced method, sought to gain deeper insights into FC alterations that may underlie pathology OCD. We collected data during movie watching from 44 patients OCD 33 healthy controls (HCs). The two-sample t test was used assess entropy between DAN, CN, DMN groups. performed for potentially confounding variables ensure robustness findings. Significant were found HC Relative HCs, showed significantly reduced DAN increased CN DMN. decreased observed study be related core symptoms OCD, such as deficit, impaired cognitive control, self-referential thinking. These results provide valuable neurobiological mechanisms highlight potential biomarker disorder. Future research should explore relationship changes severity symptoms, well their implications development treatment strategies.

Language: Английский

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