Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia DOI Creative Commons
Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse

et al.

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 87, P. 56 - 66

Published: July 30, 2024

Offspring of parents with severe mental illness (e.g., bipolar disorder or schizophrenia) are at increased risk developing psychopathology. Structural brain alterations have been found in child and adolescent offspring patients schizophrenia, but the developmental trajectories anatomy this high-familial-risk population still unclear. 300 T1-weighted scans were obtained 187 least one parent diagnosed (n=80) schizophrenia (n=53) without (n=54). The age range was 8 to 23 years old; 113 underwent two scans. Global measures regional cortical thickness surface area computed. A generalized additive mixed model used capture non-linear trajectories. had smaller total volume than (d=-0.20, p=0.004) control (d=-0.22, p=0.005) lower mean (d=-0.23, p<0.001). showed differential cerebral white matter compared (both p's=0.003). Regionally, a significantly different trajectory middle temporal gyrus versus (p<0.001) (p=0.001), which no longer significant after correcting for thickness. These findings suggest that particularly familial high is related reductions deviating global structure measures, not driven by specific regions.

Language: Английский

Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia DOI Creative Commons
Simon R. Poortman,

Jakub Jamarík,

Louise ten Harmsen van der Beek

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 72, P. 101536 - 101536

Published: Feb. 24, 2025

Offspring of parents with severe mental illness are at increased risk developing psychopathology. Identifying endophenotypic markers in high-familial-risk individuals can aid early detection and inform development prevention strategies. Using generalized additive mixed models, we compared age trajectories gyrification index (GI) sulcal morphometric measures (i.e., depth, length width) between familial for bipolar disorder or schizophrenia controls. 300 T1-weighted MRI scans were obtained 187 (53 % female, range: 8-23 years) (n = 80, n families=55) 53, families=36) controls 54, families=33). 113 underwent two scans. Globally, GI, depth decreased significantly age, width a (near-)linear manner. There no differences groups mean values any the measures. These findings suggest that, on average, young have preserved developmental patterns morphometrics during childhood adolescence.

Language: Английский

Citations

0
Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia DOI Creative Commons
Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse

et al.

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 87, P. 56 - 66

Published: July 30, 2024

Offspring of parents with severe mental illness (e.g., bipolar disorder or schizophrenia) are at increased risk developing psychopathology. Structural brain alterations have been found in child and adolescent offspring patients schizophrenia, but the developmental trajectories anatomy this high-familial-risk population still unclear. 300 T1-weighted scans were obtained 187 least one parent diagnosed (n=80) schizophrenia (n=53) without (n=54). The age range was 8 to 23 years old; 113 underwent two scans. Global measures regional cortical thickness surface area computed. A generalized additive mixed model used capture non-linear trajectories. had smaller total volume than (d=-0.20, p=0.004) control (d=-0.22, p=0.005) lower mean (d=-0.23, p<0.001). showed differential cerebral white matter compared (both p's=0.003). Regionally, a significantly different trajectory middle temporal gyrus versus (p<0.001) (p=0.001), which no longer significant after correcting for thickness. These findings suggest that particularly familial high is related reductions deviating global structure measures, not driven by specific regions.

Language: Английский

Citations

1