Ferroptosis: past, present and future

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(2)

Published: Feb. 3, 2020

Abstract Ferroptosis is a new type of cell death that was discovered in recent years and usually accompanied by large amount iron accumulation lipid peroxidation during the process; occurrence ferroptosis iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting decrease antioxidant capacity reactive oxygen species (ROS) cells, ultimately leading to oxidative death. Recent studies have shown closely related pathophysiological processes many diseases, such as tumors, nervous system ischemia-reperfusion injury, kidney blood diseases. How intervene development diseases regulating has become hotspot focus etiological research treatment, but functional changes specific molecular mechanisms still need be further explored. This paper systematically summarizes latest progress research, with on providing references for understanding its pathogenesis proposing targets treatment

Language: Английский

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Ferroptosis is a type of autophagy-dependent cell death

Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 66, P. 89 - 100

Published: March 14, 2019

Language: Английский

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The emerging role of ferroptosis in inflammation

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 127, P. 110108 - 110108

Published: March 29, 2020

Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that morphologically, biologically and genetically distinct from other types death. classified as regulated necrosis more immunogenic than apoptosis. To date, compelling evidence indicates ferroptosis plays an important role in inflammation, several antioxidants functioning inhibitors have been shown to exert anti-inflammatory effects experimental models certain diseases. Our review provides overview the link between inflammation; better understanding mechanisms underlying inflammation may hasten development promising therapeutic strategies involving address inflammation.

Language: Английский

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Molecular mechanisms of cell death in neurological diseases

Cell Death and Differentiation, Journal Year: 2021, Volume and Issue: 28(7), P. 2029 - 2044

Published: June 7, 2021

Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to establish the neural architecture shaping CNS. Abnormalities PCD cascades, such as apoptosis, necroptosis, pyroptosis, ferroptosis, associated with autophagy well unprogrammed necrosis can be observed pathogenesis of various neurological diseases. These deaths activated response forms cellular stress (exerted by intracellular or extracellular stimuli) inflammatory processes. Aberrant activation pathways is common feature neurodegenerative diseases, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's Huntington's resulting unwanted loss cells function. Conversely, inactivation thought contribute brain cancers impact their therapy. For many diseases current treatment strategies have only modest effect, engendering need for investigations into origins these With displaying aberrations pathways, it appears that agents either inhibit induce may critical components future therapeutic strategies. The therapies will guided preclinical studies animal models faithfully mimic human disease. In this review, we briefly describe processes roles they play contributing tumorigenesis brain. We also discuss interplay between distinct cascades disease pharmacological targeting key players progressed through clinical trials.

Language: Английский

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Ferroptosis and Its Role in Diverse Brain Diseases

Molecular Neurobiology, Journal Year: 2018, Volume and Issue: 56(7), P. 4880 - 4893

Published: Nov. 8, 2018

Language: Английский

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Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Free Radical Biology and Medicine, Journal Year: 2018, Volume and Issue: 133, P. 221 - 233

Published: Sept. 25, 2018

Language: Английский

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Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

Progress in Neurobiology, Journal Year: 2020, Volume and Issue: 196, P. 101890 - 101890

Published: July 26, 2020

Language: Английский

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Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

DNA and Cell Biology, Journal Year: 2019, Volume and Issue: 39(2), P. 210 - 225

Published: Dec. 6, 2019

Myocardial ischemic disease affects the prognosis in perioperative patients. Diabetes can aggravate myocardial injury. The purpose of this research is to investigate effect ferroptosis process diabetes mellitus (DM) ischemia/reperfusion (I/R) injury (IRI). Endoplasmic reticulum stress (ERS) investigated whether aggravates cardiomyocytes Rat DM+I/R (DIR), cell high glucose (HG), hypoxia reoxygenation (H/R), and high-glucose H/R (HH/R) models were established. Ferroptosis inhibitor Ferrostatin-1, agonist Erastin, ERS Salubrinal, Tunicamycin administered. Serum creatine kinase-MB (CK-MB), viability, lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS), cellular ferrous ion concentration examined. level ACSL4, GPX4, ATF4, CHOP, BCL-2, BAX was detected. tissue pathological change detected by hematoxylin-eosin staining. Cardiac function monitored invasive hemodynamic measurements. Evans Blue-triphenyltetrazolium chloride double staining used detect infarct size. In DM+sham (DS) (or HG) I/R H/R) models, injured accompanied increased ERS. Moreover, more serious rat DIR or HH/R models. Inhibition model could reduce H9c2 cells HG, H/R, Erastin stimulating model. Meanwhile, inhibition alleviate involved that related injury, which may provide a therapeutic regent for disease.

Language: Английский

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Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

American Journal Of Pathology, Journal Year: 2019, Volume and Issue: 190(1), P. 68 - 81

Published: Oct. 11, 2019

Language: Английский

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Targeting ferroptosis opens new avenues for the development of novel therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 21, 2023

Abstract Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation. Recent studies have provided compelling evidence supporting the notion that ferroptosis plays a key pathogenic role in many diseases such as various cancer types, neurodegenerative disease, involving tissue and/or organ injury, inflammatory infectious diseases. Although precise regulatory networks underlie are largely unknown, particularly respect to initiation progression diseases, recognized bona fide target for further development treatment prevention strategies. Over past decade, considerable progress has been made developing pharmacological agonists antagonists these ferroptosis-related conditions. Here, we provide detailed overview our current knowledge regarding ferroptosis, its pathological roles, regulation during disease progression. Focusing on use chemical tools preclinical studies, also summarize recent advances targeting across growing spectrum ferroptosis-associated Finally, discuss new challenges opportunities potential strategy treating

Language: Английский

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