Glioblastoma Therapy: Past, Present and Future

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2529 - 2529

Published: Feb. 21, 2024

Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer. Although great efforts have been made by clinicians researchers, no significant improvement in survival has achieved since Stupp protocol became standard care (SOC) 2005. Despite multimodality treatments, recurrence is almost universal with rates under 2 years after diagnosis. Here, we discuss recent progress our understanding GB pathophysiology, particular, importance glioma stem cells (GSCs), tumor microenvironment conditions, epigenetic mechanisms involved growth, aggressiveness recurrence. The discussion on therapeutic strategies first covers SOC treatment targeted therapies that shown to interfere different signaling pathways (pRB/CDK4/RB1/P16

Language: Английский

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Vagus Nerve Stimulation: Novel Concept for the Treatment of Glioblastoma and Solid Cancers by Cytokine (Interleukin-6) Reduction, Attenuating the SASP, Enhancing Tumor Immunity

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 42, P. 100859 - 100859

Published: Sept. 17, 2024

Language: Английский

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The Antiglioma Potential of Plant Lectins: Molecular Targets, Mechanisms, and Future Directions

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 5 - 5

Published: Feb. 2, 2025

Gliomas, ranging from low-grade pilocytic astrocytomas to highly malignant glioblastomas, are primary brain tumors that originate neural or glial stem cells. Classified by the WHO into grades 1 4, these exhibit varying prognoses, with oligodendrogliomas and having better intermediate outcomes, respectively, while glioblastomas associated a poor prognosis. Despite advancements in molecular genetic research have improved diagnosis development of targeted therapies, treating high-grade gliomas remains significant challenge due their diffuse nature. In this context, lectins, carbohydrate-binding proteins, shown promise as diagnostic therapeutic agents for cancer, including gliomas. Plant particularly those legumes, antiproliferative effects on glioma These include decreased cell viability migration, alongside induction autophagy apoptosis, suggesting potential agents. Although mechanisms underlying not yet fully understood, targets pathways involved antiglioma activity lectins been identified. Key matrix metalloproteinases (MMPs), epidermal growth factor receptor (EGFR), CD98 (xc- system), AMPA receptor, CD73. This review focuses legume applications, main based functions, structures, mechanisms.

Language: Английский

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Enhancing the therapeutic efficacy of tumor-treating fields (TTFields): further perspectives

Clinical & Translational Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

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Neuromodulation as an anticancer strategy

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(21), P. 20521 - 20522

Published: Oct. 17, 2023

There may be a role for vagus nerve stimulation as an anticancer strategy. This include the modulation of signalling between nerves and tumour cells epigenetic influences, in addition to reduction oxidative stress, anti‐inflammatory endocrine mechanisms.

Language: Английский

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The Case for Neurosurgical Intervention in Cancer Neuroscience

Neurosurgery, Journal Year: 2024, Volume and Issue: unknown

Published: June 21, 2024

The emerging field of cancer neuroscience reshapes our understanding the intricate relationship between nervous system and biology; this new paradigm is likely to fundamentally change advance neuro-oncological care. profound interplay cancers reciprocal: Cancer growth can be induced regulated by system; conversely, tumors themselves alter system. Such crosstalk cells evident in both peripheral central systems. Recent advances have uncovered numerous direct neuron-cancer interactions at glioma-neuronal synapses, paracrine mechanisms within tumor microenvironment, indirect neuroimmune interactions. Neurosurgeons historically played a role care, as becoming increasingly established, neurosurgical intervention clearer. Examples include denervation procedures, delineation neuron-glioma networks, development neuroprostheses, neuromodulatory advanced local delivery present review seeks highlight key with implications outline future neuroscience.

Language: Английский

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Neural stem cells and pediatric hydrocephalus: further observations

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(3)

Published: March 1, 2024

Journal Article Neural stem cells and pediatric hydrocephalus: further observations Get access Ashwin Kumaria Senior Fellow in Neurosurgery, Department of Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, United KingdomClinical Trustee, Harry's Hydrocephalus Awareness Trust (Harry's HAT), Yateley, Hampshire GU46 6EB, Kingdom Corresponding author: Kingdom. Email: [email protected] https://orcid.org/0000-0002-8145-0374 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cerebral Cortex, Volume 34, Issue 3, March 2024, bhae086, https://doi.org/10.1093/cercor/bhae086 Published: 14 2024 history Received: 09 February Revision received: 17 Accepted: 19

Language: Английский

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A common tumour in a rare location: a single centre case series of cerebellar glioblastoma

British Journal of Neurosurgery, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 6

Published: May 14, 2024

Although glioblastoma is the commonest primary brain tumour in adults, its location cerebellum extremely rare. We present thirteen cases (3 female, 10 male; median age at presentation 56 [age range 21-77]) of surgically managed, histologically confirmed, cerebellar (cGB) over a 17 year period (2005-2022). Pre-operative radiological diagnosis was challenging given cGB rarity, although MRI demonstrated ring enhancement all cases. Surgical management included posterior fossa craniectomy and debulking 11 burr hole biopsy two. CSF diversion necessary four No evidence IDH or ATRX gene mutations found when tested. Survival ranged from 1 to 22 months after (mean 10.9 months). also seek understand why rare this discuss potential reasons for this. hypothesise that increasing anatomical distance germinal regions decreased local endogenous neural stem cell activity (which has been associated with glioblastoma) may explain cerebellum. hereby add limited literature on as largest UK series date.

Language: Английский

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GAD1 ameliorates glioma progression through regulating cuproptosis via RAS/MAPK pathway

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(10)

Published: Sept. 12, 2024

Abstract Glioma represents a primary malignant tumor occurring in the central nervous system. Glutamate decarboxylase (GAD1) plays significant role development; however, its function of GAD1 and underlying mechanisms glioma progression remain unclear. Differentially expressed genes (DEGs) obtained from GSE12657 GSE15209 datasets that intersected with cuproptosis‐related pivot were identified using comprehensive bioinformatics methods. The elesclomol (ES) treatment was used to induce cuproptosis U251 cells, which validated by detecting intracellular copper levels marker expression. Lentivirus‐mediated gene overexpression performed explore effects functional assays vitro mouse xenograft model. RAS agonist ML098 verify effect on RAS/MAPK pathway cells. A total 87 DEGs seven hub obtained, five upregulated two downregulated gliomas. Overexpression inhibited proliferation, invasion, migration, promoted apoptosis suppressed tumorigenesis vivo. In addition, enhanced sensitivity cells cuproptosis. Additionally, attenuated inhibitory phenotype ES‐treated an anti‐oncogenic regulating via inhibition pathway.

Language: Английский

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Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(10), P. 6970 - 6982

Published: Sept. 3, 2024

Language: Английский

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