Research progress of ferroptosis in brain injury DOI
Yi Cao

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Nov. 10, 2024

Ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxidation, has emerged as key contributor to neuronal damage in various types brain injury, including traumatic injury (TBI) and ischemic caused brian ischemia (BI). This review summarizes the underlying mechanisms ferroptosis injuries highlights its role exacerbating loss, inflammation, secondary damage. After TBI, release free iron oxidative stress after triggers ferroptosis, contributing long-term neurological deficits. Similarly, BI, is initiated accumulation reactive oxygen species (ROS) mitochondrial dysfunction during reperfusion, further amplifying The current provides comprehensive overview interplay between with an emphasis on potential targeting improve recovery outcomes patients. Future research directions include development novel inhibitors integration ferroptosis-targeting strategies existing treatment modalities.

Language: Английский

Innovative Insights into Traumatic Brain Injuries: Biomarkers and New Pharmacological Targets DOI Open Access
Serena Silvestro, Ivana Raffaele, Angelo Quartarone

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2372 - 2372

Published: Feb. 17, 2024

A traumatic brain injury (TBI) is a major health issue affecting many people across the world, causing significant morbidity and mortality. TBIs often have long-lasting effects, disrupting daily life functionality. They cause two types of damage to brain: primary secondary. Secondary particularly critical as it involves complex processes unfolding after initial injury. These can lead cell death in brain. Understanding how these crucial for finding new treatments. This review examines wide range literature from 2021 2023, focusing on biomarkers molecular mechanisms pinpoint therapeutic advancements. Baseline levels biomarkers, including neurofilament light chain (NF-L), ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), Tau, glial fibrillary acidic protein (GFAP) TBI, demonstrated prognostic value cognitive outcomes, laying groundwork personalized treatment strategies. In terms pharmacological progress, most promising approaches currently target neuroinflammation, oxidative stress, apoptotic mechanisms. Agents that modulate pathways offer potential reduce TBI's impact aid neurological rehabilitation. Future research poised refine approaches, potentially revolutionizing TBI treatment.

Language: Английский

Citations

21
Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment DOI Creative Commons

Hua Su,

Zhongan Wang,

Lidan Zhou

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: June 10, 2024

This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on integumentary, respiratory, cardiovascular, urinary, and skeletal systems, study highlights versatility MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge central mediators antioxidative anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung even offering solutions for conditions like myocardial infarction renal ischemia-reperfusion injury, demonstrate promising efficacy. Their adaptability different administration routes identifying specific factors opens avenues innovative regenerative strategies. positions candidates future clinical applications, providing a overview medicine.

Language: Английский

Citations

8
An Overview on the Physiopathology of the Blood–Brain Barrier and the Lipid-Based Nanocarriers for Central Nervous System Delivery DOI Creative Commons
Francesca Susa, Silvia Arpicco, Candido Fabrizio Pirri

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 849 - 849

Published: June 22, 2024

The state of well-being and health our body is regulated by the fine osmotic biochemical balance established between cells different tissues, organs, systems. Specific districts human are defined, kept in correct functioning, and, therefore, protected from exogenous or endogenous insults both mechanical, physical, biological nature presence barrier In addition to placental barrier, which even acts as a linker two organisms, mother fetus, all barriers, including blood-brain (BBB), blood-retinal blood-nerve blood-lymph blood-cerebrospinal fluid operate maintain physiological homeostasis within tissues organs. From pharmaceutical point view, most challenging undoubtedly BBB, since its notably complicates treatment brain disorders. BBB action can impair delivery chemical drugs biopharmaceuticals into brain, reducing their therapeutic efficacy and/or increasing unwanted bioaccumulation surrounding healthy tissues. Recent nanotechnological innovation provides advanced biomaterials ad hoc customized engineering functionalization methods able assist brain-targeted drug delivery. this context, lipid nanocarriers, synthetic (liposomes, solid nanoparticles, nanoemulsions, nanostructured carriers, niosomes, proniosomes, cubosomes) cell-derived ones (extracellular vesicles cell membrane-derived nanocarriers), considered one successful systems due reasonable biocompatibility ability cross BBB. This review aims provide complete up-to-date view on varied whether FDA-approved, involved clinical trials, used vitro vivo studies, for inflammatory, cancerous, infectious diseases.

Language: Английский

Citations

6
Extracellular vesicles derived from mesenchymal stem cells alleviate depressive-like behavior in a rat model of chronic stress DOI

Zaquer Suzana Munhoz Costa-Ferro,

Rita Cunha, Erik Aranha Rossi

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 366-367, P. 123479 - 123479

Published: Feb. 20, 2025

Language: Английский

Citations

0
Ntoco Promotes Ferroptosis via Hnrnpab‐Mediated NF‐κB/Lcn2 Axis Following Traumatic Brain Injury in Mice DOI Creative Commons
Qiang Wang,

Han‐Jun Zuo,

Huaqin Sun

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Objective Emerging evidence highlights the involvement of long non‐coding RNAs (lncRNAs) and ferroptosis in pathogenesis traumatic brain injury (TBI). However, regulatory role lncRNAs TBI‐induced remains poorly understood. This study aims to investigate a specific lncRNA, noncoding transcript chemokine (C‐C motif) ligand 4 ( Ccl4 ) overlapping Ntoco ), regulation following TBI explore its potential as therapeutic target. Methods The expression levels controlled cortical (CCI) mice were measured using real‐time PCR. Behavioral tests post‐injury assessed rotarod test Morris water maze, lesion volume was evaluated micro‐MRI. binding proteins identified RNA pull‐down immunoprecipitation. sequencing employed identify ‐related pathways. Western blotting co‐immunoprecipitation used measure protein ubiquitination processes. Results upregulation observed CCI mice. knockdown inhibited neuron ferroptosis, reduced volume, improved spatial memory TBI. overexpression promoted neurons. Mechanistically, facilitated K48‐linked degradation by Hnrnpab, suppressing NF‐κB/Lcn2 signaling pathway. included phosphorylation IkBα, increased IKKα/β, nuclear translocation NF‐κB p65 subunit, elevated Lcn2 expression. Conclusion Our findings suggest that plays crucial modulating Targeting may provide promising strategy mitigate improve outcomes

Language: Английский

Citations

0
Transcription factor NFKB1 mediates TUBB6 to promote the proliferation and suppress apoptosis in glioma via Wnt/β-catenin signaling pathway DOI Creative Commons
Yan Li, Ziyu Shao, Jun Jiang

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 1, 2025

Glioma remains one of the most challenging brain tumors with poor prognosis. In this study, we aimed to elucidate role TUBB6 in glioma and its potential as a diagnostic prognostic biomarker. Analysis GSE42656 TCGA datasets revealed that was significantly upregulated tissues compared normal tissues. The value demonstrated an area under curve (AUC) 0.702, suggesting it could be used biomarker differentiate gliomas Correlation analyses high expressions were associated advanced WHO grades, IDH mutation status, histological types glioma. Further investigation identified NFKB1 key transcription factor binds promoter region TUBB6, upregulating expression cells. Elevated levels overall survival disease-specific patients. Knockdown resulted reduced cells, confirming regulatory roles expression. Prognostic analysis using CGGA poorer (OS) (DSS) independent for both OS DSS. Additionally, pan-cancer dysregulated various tumor showed across multiple cancers. Functional enrichment TUBB6-associated differentially expressed genes indicated involvement immune response, extracellular matrix remodeling, cytokine signaling pathways. vitro experiments knockdown suppressed cell proliferation promoted apoptosis by regulating canonical Wnt/β-catenin pathway. Our findings suggest contributes malignancy through effects on conclusion, emerges promising diagnosis Its regulation pathways underscore therapeutic target treatment.

Language: Английский

Citations

0
LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review DOI

Shayan Khalilollah,

Sina Kalantari Soltanieh,

Raed Obaid Saleh

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 179, P. 156585 - 156585

Published: April 4, 2024

Language: Английский

Citations

3
Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases DOI Creative Commons
Bohua Wei, Mengting Wei,

Haonan Huang

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

The global increase in the aging population has led to a concurrent rise incidence of age-related diseases, posing substantial challenges healthcare systems and affecting well-being elderly. Identifying securing effective treatments become an urgent priority. In this context, mesenchymal stem cell-derived exosomes (MSC-Exos) have emerged as promising innovative modality field anti-aging medicine, offering multifaceted therapeutic approach. MSC-Exos demonstrate significant potential due their immunomodulatory anti-inflammatory properties, ability inhibit oxidative stress, reparative effects on senescent tissues. These attributes make them valuable combating range conditions associated with aging, such cardiovascular neurodegeneration, skin osteoarthritis. integration membrane-penetrating peptides introduces novel strategy for delivery biomolecules, surmounting traditional cellular barriers enhancing efficacy. This review provides comprehensive synthesis current understanding MSC-Exos, underscoring role potent against intricate diseases.

Language: Английский

Citations

2
Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury DOI
Zhiqiang Tang, Shuyun Xu,

Shucheng Zhao

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 249, P. 108648 - 108648

Published: Nov. 19, 2024

Language: Английский

Citations

1
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review DOI Creative Commons

Lebin Ke,

Yingying Cao,

Zhiwei Lü

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 9, 2024

Neurological disorders are being increasingly recognized as major causes of death and disability around the world. refer to a broad range medical conditions that affect brain spinal cord. These can have various causes, including genetic factors, infections, trauma, autoimmune reactions, or neurodegenerative processes. Each disorder has its own unique symptoms, progression, treatment options. Optimal communication between interneurons neuron-glia cells within homeostatic microenvironment is paramount importance. Within this microenvironment, exosomes play significant role in promoting intercellular by transferring diverse cargo contents, proteins, lipids, non-coding RNAs (ncRNAs). Partially, nervous system homeostasis preserved stem cell-derived exosomal ncRNAs, which include circular (circRNAs), long noncoding (lncRNAs), microRNAs (miRNAs), PIWI-interacting (piRNAs). The diversity these ncRNAs suggests their potential influence multiple pathways cellular processes system. Stem ncRNA contents been investigated for therapeutic uses neurological disorders, owing demonstrated capabilities neuroprotection, neuroregeneration, modulation disease-related pathways. ability cross blood-brain barrier makes them promising delivery vehicle ncRNAs. This review aims summarize current understanding different clinical applications.

Language: Английский

Citations

0