medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 28, 2023
Abstract
Understanding
the
complex
causal
relationships
among
major
clinical
outcomes
and
interplay
multiple
organs
remains
a
significant
challenge.
By
using
imaging
phenotypes,
we
can
characterize
functional
structural
architecture
of
human
organs.
Mendelian
randomization
(MR)
provides
valuable
framework
for
inferring
causality
by
leveraging
genetic
variants
as
instrumental
variables.
In
this
study,
conducted
systematic
multi-organ
MR
analysis
involving
402
traits
372
outcomes.
Our
revealed
184
links
58
diseases
56
across
various
organs,
tissues,
systems,
including
brain,
heart,
liver,
kidney,
lung,
pancreas,
spleen,
adipose
tissue,
skeletal
system.
We
identified
intra-organ
connections,
such
bidirectional
between
Alzheimer’s
disease
brain
function,
well
inter-organ
effects,
impact
heart
on
health.
Metabolic
disorders,
diabetes,
exhibited
effects
These
findings
shed
light
spanning
providing
insights
into
intricate
organ
functions
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 15, 2024
Background
Functional
magnetic
resonance
imaging
(fMRI)
is
a
useful
tool
to
evaluate
brain
inefficiencies
secondary
cardiovascular
diseases
(CVDs);
nevertheless,
limited
fMRI
studies
have
been
conducted
investigate
the
effect
of
CVDs
on
functional
changes
and
cognitive
function.
This
systematic
review
aims
explore,
synthesise,
report
outcomes
(resting
state
task-based)
performance
in
patients
with
CVDs.
Methods
Two
reviewers
independently
searched
published
literature
until
April
2024
ScienceDirect,
PubMed,
Web
Science,
ClinicalTrials.gov
adhering
PRISMA
protocol.
A
total
26
eligible
were
considered
for
full-text
screening,
which
10
included
this
review.
The
methodological
quality
was
assessed
by
mixed
methods
appraisal
reported
as
empirically
fair.
Results
Among
336
subjects
CVDs,
aged
between
49.90
±
6.10
72.20
5.70
years,
majority
had
coronary
artery
(n
=
177,
52.68%)
hypertension
200,
59.52%),
approximately
half
them
females
169,
50.30%).
Based
qualitative
synthesis,
demonstrated
an
increased
decline
(reduced
Mini-Mental
State
Examination/Montreal
Cognitive
Assessment
mean
values)
attenuated
task
(lower
2-back
scores
slower
reaction
time).
also
indicated
impaired
activity
at
supplementary
motor
area
associated
poor
ejection
fraction;
reduced
default
mode
network
suppression
linked
high
low-density
lipoprotein
cholesterol;
lower
regional
homogeneity
amplitude
low-frequency
fluctuation
values;
connectivity.
In
summary,
alterations
networks
connectivity
may
contributed
diseases.
Conclusion
It
can
be
extrapolated
that
tend
alter
result
impairment
poorer
performance.
However,
future
studies,
more
stringent
homogenous
demographic
data
are
highly
recommended.
Electronics,
Journal Year:
2023,
Volume and Issue:
12(11), P. 2419 - 2419
Published: May 26, 2023
Echo-doppler
examination
of
the
jugular
vessel
is
a
powerful
tool
for
early
diagnosis
cardiovascular
disorders
that
can
be
further
related
to
central
nervous
system
diseases.
Unfortunately,
ultrasound
technique
strongly
operator-dependent,
so
quality
scan,
accuracy
measurement,
and
therefore
rapidity
robustness
reflect
degree
training.
The
paper
presents
development
mechatronic
simulation
improving
skill
novice
physicians
in
echo-doppler
procedures.
patient
simulated
by
silicone
manikin
whose
materials
are
designed
have
realistic
response.
Two
tubes
allow
blood-mimicking
fluid
flow
inside
manikin,
simulating
hemodynamics
internal
vein.
controlling
waveform,
reproduce
several
clinical
cases
interest
diagnosis.
experiments
investigate
measurements
performed
on
proposed
operators
using
real
scanner.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 28, 2023
Abstract
Understanding
the
complex
causal
relationships
among
major
clinical
outcomes
and
interplay
multiple
organs
remains
a
significant
challenge.
By
using
imaging
phenotypes,
we
can
characterize
functional
structural
architecture
of
human
organs.
Mendelian
randomization
(MR)
provides
valuable
framework
for
inferring
causality
by
leveraging
genetic
variants
as
instrumental
variables.
In
this
study,
conducted
systematic
multi-organ
MR
analysis
involving
402
traits
372
outcomes.
Our
revealed
184
links
58
diseases
56
across
various
organs,
tissues,
systems,
including
brain,
heart,
liver,
kidney,
lung,
pancreas,
spleen,
adipose
tissue,
skeletal
system.
We
identified
intra-organ
connections,
such
bidirectional
between
Alzheimer’s
disease
brain
function,
well
inter-organ
effects,
impact
heart
on
health.
Metabolic
disorders,
diabetes,
exhibited
effects
These
findings
shed
light
spanning
providing
insights
into
intricate
organ
functions
