cAMP-PKA signaling pathway and anxiety: Where do we go next?

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111311 - 111311

Published: July 24, 2024

Language: Английский

Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression‐Related Behaviors by Urolithin B via the SIRT1‐FOXO1 Pathway

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)

Published: April 1, 2025

ABSTRACT Aims Conventional antidepressants exhibit limited efficacy and delayed onset. This study aimed to elucidate the antidepressant effects of urolithin B (UB) its regulatory role in microglia‐mediated hippocampal neuronal dysfunction. Methods The mouse model depression was established using both chronic unpredicted stress (CUS) lipopolysaccharide (LPS) injection. therapeutic UB assessed through behavioral paradigms. microglia activation, cellular cytotoxicity apoptosis levels, underlying molecular mechanisms were delineated utilizing proteomics analysis, immunofluorescence staining, real‐time PCR Western blotting. Results efficiently alleviated depression‐related behaviors, accompanied by suppressed neuroinflammation, changes classic activation (M1)/alternative (M2) polarization recovered sirtuin‐1 (SIRT1) forkhead box protein O1 (FOXO1) expression hippocampus. Additionally, reduced HT22 cells phenotypes treated supernatant from LPS‐incubated BV2 cells, which mediated SIRT1‐FOXO1 pathway. analysis content revealed abundant secreting proteins among LPS/UB application. Conclusion confirmed that microglial SIRT1 mediates UB's effects, positioning as a promising candidate for targeting neuroinflammatory pathways.

Language: Английский

Interleukin-11Rα2 in the hypothalamic arcuate nucleus affects depression-related behaviors and the AKT-BDNF pathway

Gene, Journal Year: 2024, Volume and Issue: 933, P. 148966 - 148966

Published: Sept. 26, 2024

Language: Английский