The possible role of neurogenesis activators in temporal lobe epilepsy: State of art and future perspective DOI Creative Commons

Ahmed Salem Al-Dhahi,

Hayder M. Al‐kuraishy,

Ali K. Albuhadily

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177646 - 177646

Published: April 1, 2025

Neurogenesis is a complex process by which the neurons and supporting cells of central nervous system (CNS) are generated neural stem cells. Adult hippocampal neurogenesis (AHN) in human brain an active during life plays critical role regulation memory, cognition, mood. It has been shown that epilepsy linked with dysregulation AHN. Of note, AHN very sensitive to pathological electrical stimuli epileptic seizures, result induction acute inhibition chronic epilepsy. Epileptic seizure-induced neurodegeneration activates mobilization substitute for loss temporal lobe (TLE), most refractory type Moreover, recurrent seizures TLE trigger certain regions. However, transient seizure terminated 1-4 weeks following status epilepticus (SE). Nevertheless, adult dramatically reduced associated development cognitive impairment TLE. These findings indicate severity seizures. Hence, activators may attenuate pathogenesis Therefore, this review aims discuss explain beneficial how could be effective management

Language: Английский

The possible role of neurogenesis activators in temporal lobe epilepsy: State of art and future perspective DOI Creative Commons

Ahmed Salem Al-Dhahi,

Hayder M. Al‐kuraishy,

Ali K. Albuhadily

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177646 - 177646

Published: April 1, 2025

Neurogenesis is a complex process by which the neurons and supporting cells of central nervous system (CNS) are generated neural stem cells. Adult hippocampal neurogenesis (AHN) in human brain an active during life plays critical role regulation memory, cognition, mood. It has been shown that epilepsy linked with dysregulation AHN. Of note, AHN very sensitive to pathological electrical stimuli epileptic seizures, result induction acute inhibition chronic epilepsy. Epileptic seizure-induced neurodegeneration activates mobilization substitute for loss temporal lobe (TLE), most refractory type Moreover, recurrent seizures TLE trigger certain regions. However, transient seizure terminated 1-4 weeks following status epilepticus (SE). Nevertheless, adult dramatically reduced associated development cognitive impairment TLE. These findings indicate severity seizures. Hence, activators may attenuate pathogenesis Therefore, this review aims discuss explain beneficial how could be effective management

Language: Английский

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