A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases DOI Creative Commons
Adam Hage,

Marianne Janes,

Sonja M. Best

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 562 - 562

Published: April 14, 2025

Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects biology has made TRIM a focus study many fields illuminated the negative impact they exert when functioning improperly. Disruption function been linked to success various pathogens separately occurrence development several neurodegenerative diseases, making appealing candidate for novel therapeutic approaches. Here, we review current findings on demonstrate their analogous properties distinct viral infection central nervous system (CNS) disorders. We also examine recent advancements drug targeted degradation as potential strategies TRIM-mediated treatments discuss implications these technologies have future research directions.

Language: Английский

Inhibitor of Growth Proteins: Epigenetic Regulators Shaping Neurobiology DOI Creative Commons
Ziyue Xu,

Hongyu Xu,

Jichun Shi

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 281 - 281

Published: Feb. 14, 2025

The inhibitor of growth (ING) family proteins is emerging as a pivotal regulator epigenetic modifications within the nervous system. These are involved in various cellular processes, including apoptosis, cell cycle control, and DNA repair, through interactions with chromatin-modifying complexes. Recent studies underscore dual role ING both tumor suppression neuronal differentiation, development, neuroprotection. This review summarizes functions neurobiology, focus on their involvement neural development relevance to neuro-oncological diseases. We explore mechanisms by which influence chromatin state gene expression, highlighting histone acetyltransferases, deacetylases, methyltransferases, modification enzymes, non-coding RNAs. A deeper understanding regulation system may pave way for novel therapeutic strategies targeting neurological disorders.

Language: Английский

Citations

0
A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases DOI Creative Commons
Adam Hage,

Marianne Janes,

Sonja M. Best

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 562 - 562

Published: April 14, 2025

Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects biology has made TRIM a focus study many fields illuminated the negative impact they exert when functioning improperly. Disruption function been linked to success various pathogens separately occurrence development several neurodegenerative diseases, making appealing candidate for novel therapeutic approaches. Here, we review current findings on demonstrate their analogous properties distinct viral infection central nervous system (CNS) disorders. We also examine recent advancements drug targeted degradation as potential strategies TRIM-mediated treatments discuss implications these technologies have future research directions.

Language: Английский

Citations

0