Laryngeal Squamous Cell Carcinoma Is Characterized by a Stronger Expression of Nectin-4 Compared to Nectin-2 DOI Creative Commons
Matej Maršić, Nives Jonjić, Maja Gligora Marković

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 296 - 296

Published: April 23, 2025

Nectin-2 and Nectin-4 are cell adhesion molecules associated with the progression of various cancers. The main goal this pilot study was to evaluate expression patterns in laryngeal squamous carcinoma (LSCC). A retrospective conducted on tissue microarray (TMA) samples derived from 31 patients who underwent total laryngectomy. findings revealed heterogenous both tumor cells surrounding stroma, being significantly higher than expression. Specifically, 74% cases showed weak cytoplasmic staining for Nectin-2, while 41.93% exhibited strong Nectin-4. Both expressions were more pronounced at invasive margins. Although no significant differences observed across grades (W = 83.500; z −0.463; p 0.658), noted. Well-differentiated tumors (Grade 1), 80.65% cases, predominantly membranous staining, including epithelial mucosal surface. Conversely, less-differentiated 2 3), a shift toward evident. 74.19% Grade 100% 3 predominant localization This transition also evident normal superficial epithelium malignant tissue. These observations suggest that alterations subcellular may be carcinogenesis could serve as potential markers assessment precancerous lesions aggressiveness tumors.

Language: Английский

Laryngeal Squamous Cell Carcinoma Is Characterized by a Stronger Expression of Nectin-4 Compared to Nectin-2 DOI Creative Commons
Matej Maršić, Nives Jonjić, Maja Gligora Marković

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 296 - 296

Published: April 23, 2025

Nectin-2 and Nectin-4 are cell adhesion molecules associated with the progression of various cancers. The main goal this pilot study was to evaluate expression patterns in laryngeal squamous carcinoma (LSCC). A retrospective conducted on tissue microarray (TMA) samples derived from 31 patients who underwent total laryngectomy. findings revealed heterogenous both tumor cells surrounding stroma, being significantly higher than expression. Specifically, 74% cases showed weak cytoplasmic staining for Nectin-2, while 41.93% exhibited strong Nectin-4. Both expressions were more pronounced at invasive margins. Although no significant differences observed across grades (W = 83.500; z −0.463; p 0.658), noted. Well-differentiated tumors (Grade 1), 80.65% cases, predominantly membranous staining, including epithelial mucosal surface. Conversely, less-differentiated 2 3), a shift toward evident. 74.19% Grade 100% 3 predominant localization This transition also evident normal superficial epithelium malignant tissue. These observations suggest that alterations subcellular may be carcinogenesis could serve as potential markers assessment precancerous lesions aggressiveness tumors.

Language: Английский

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