Low‐Frequency Deep Brain Stimulation in Non‐Rapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease DOI Creative Commons
Damian M. Herz,

Jenny Blech,

Yaroslav Winter

et al.

Movement Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Background and Objective Memory impairment is a frequent debilitating symptom in neurodegenerative disorders. The objective of this study was to provide proof‐of‐principle that deep brain stimulation during sleep can modify memory consolidation people with Parkinson's disease depending on the frequency applied. Methods Twenty‐four patients who were treated subthalamic nucleus included single‐blind pilot study. Six had be excluded because insomnia night testing. Patients randomized (1:1 ratio) receiving either low (4 Hz) or clinically used high (130 early non‐rapid eye movement (NREM) sleep. main outcome measure overnight retention as measured by validated declarative task. Results NREM (n = 9, 4 females, mean age 61.1 ± 4.3 years) showed improved ( z 2.549, P 0.011). 2 62.2 7.1) did not show any improvement 1.023, 0.306) leading significant difference between groups 2.214, 0.027). Stronger function correlated increased cortical activity after electroencephalography (ρ 0.711, 0.037). Conclusion These results modulated frequency‐specific © 2024 Author(s). Movement Disorders published Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Language: Английский

DBS-induced gamma entrainment as a new biomarker for motor improvement with neuromodulation DOI Creative Commons
Varvara Mathiopoulou, Jeroen Habets, Lucia K. Feldmann

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 26, 2024

Abstract Finely tuned gamma oscillations have been recorded from the subthalamic nucleus and cortex in Parkinson’s disease patients undergoing deep brain stimulation are often associated with dyskinesia. More recently, it was shown that entrains finely to ½ of frequency; however, functional role this signal is not yet fully understood. We local field potentials 19 chronically implanted under effective dopaminergic medication during increasing amplitude, while they were at rest repetitive hand movements. analyzed effect intensity on band 1:2 entrainment compared entrained movement. Spontaneous present eight out (peak frequency μ = 78.4 ±4.3 Hz). High-frequency induced 15 patients. Entrainment occurred a mean amplitude 2.2 0.75 mA disappeared or decreased power higher three In spontaneous gamma, progressive shift until locked entrainment. Only five activity showed dyskinesia stimulation. Further, there significant increase movement comparison rest. Finally, had faster movements as those without These findings argue for relevance stimulation-induced prokinetic that, necessarily promoting Previously published electrophysiological models fit well our results support can be promising real-life biomarker closed-loop

Language: Английский

Citations

2
How to design optimal brain stimulation to modulate phase-amplitude coupling? DOI Creative Commons
Benoit Duchet, Rafał Bogacz

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(4), P. 046006 - 046006

Published: July 10, 2024

Abstract Objective. Phase-amplitude coupling (PAC), the of amplitude a faster brain rhythm to phase slower rhythm, plays significant role in activity and has been implicated various neurological disorders. For example, Parkinson’s disease, PAC between beta (13–30 Hz) gamma (30–100 rhythms motor cortex is exaggerated, while Alzheimer’s theta (4–8 diminished. Modulating (i.e. reducing or enhancing PAC) using stimulation could therefore open new therapeutic avenues. However, it previously reported that phase-locked can increase PAC, unclear what optimal strategy modulate might be. Here, we provide theoretical framework narrow down experimental optimisation aimed at modulating which would otherwise rely on trial error. Approach. We make analytical predictions Stuart–Landau model, confirm these more realistic model coupled neural populations. Main results. Our specifies critical Fourier coefficients waveform should be tuned optimally PAC. Depending characteristics response curve fast population, components may include slow frequency, combinations these, as well their harmonics. also show balance energy depends relative strength endogenous rhythms, alignment with change throughout cycle. Furthermore, identify conditions requiring phase-lock and/or rhythms. Significance. Together, our lays foundation for guiding development innovative effective benefit.

Language: Английский

Citations

2
Physiological effects of dual target DBS in an individual with Parkinson's disease and a sensing-enabled pulse generator DOI Creative Commons
Daniel D. Cummins, Stephanie S. Sandoval-Pistorius, Stephanie Cernera

et al.

Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 122, P. 106089 - 106089

Published: March 6, 2024

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus (GP) is an established therapy for Parkinson's disease (PD). Novel DBS devices can record local field potential (LFP) physiomarkers from STN GP. While beta (13-30 Hz) and gamma (40-90 GP LFP oscillations correlate with PD motor severity therapeutic effects treatments, STN-GP interactions in electrophysiology patients are not well characterized.

Language: Английский

Citations

1
Pre-existing oscillatory activity as a condition for sub-harmonic entrainment of finely tuned gamma in Parkinson's disease DOI Creative Commons

James J. Sermon,

Philip A. Starr, Timothy Denison

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(2), P. 488 - 490

Published: March 1, 2024

Language: Английский

Citations

1
Evoked resonant neural activity long-term dynamics can be reproduced by a computational model with vesicle depletion DOI Creative Commons

James J. Sermon,

Christoph Wiest, Huiling Tan

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106565 - 106565

Published: June 14, 2024

Subthalamic deep brain stimulation (DBS) robustly generates high-frequency oscillations known as evoked resonant neural activity (ERNA). Recently the importance of ERNA has been demonstrated through its ability to predict optimal DBS contact in subthalamic nucleus patients with Parkinson's disease. However, underlying mechanisms are not well understood, and previous modelling efforts have managed reproduce wealth published data describing dynamics ERNA. Here, we aim present a minimal model capable reproducing characteristics slow date. We make biophysically-motivated modifications Kuramoto fit parameters obtained from data. Our results demonstrate that it is possible (over hundreds seconds) single neuronal population, and, crucially, vesicle depletion one key behind frequency decay our model. further validate proposed against experimental disease patients, where captures variations amplitude response variable frequency, amplitude, pulse bursting. provide series predictions could be subject future studies for validation.

Language: Английский

Citations

1
Sustained Clinical Benefit of Adaptive Deep Brain Stimulation in Parkinson's Disease Using Gamma Oscillations: A Case Report DOI
Stephanie Cernera, Carina R. Oehrn, Lauren H. Hammer

et al.

Movement Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Background Adaptive deep brain stimulation (aDBS) dynamically adjusts parameters according to patient needs. We recently showed that chronic aDBS utilizing invasive neural signals for feedback control is superior conventional DBS (cDBS) during normal daily life in a 2‐month trial. The stability of over longer periods remains unclear. Objectives To assess the effects on motor symptoms and quality (QoL) one individual with Parkinson's disease 8 months. Methods used stimulation‐entrained cortical gamma oscillations as signal subthalamic nucleus quantified benefits using diary ratings, QoL scales, wearable metrics. Results found delivered consistent compared baseline cDBS measures bradykinesia QoL. Conclusions can achieve prolonged, stable improvement clinically optimized cDBS. stable, remain appropriate extended periods. © 2024 International Parkinson Movement Disorder Society.

Language: Английский

Citations

1
How to design optimal brain stimulation to modulate phase-amplitude coupling? DOI Creative Commons
Benoit Duchet, Rafał Bogacz

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 12, 2024

Abstract Objective Phase-amplitude coupling (PAC), the of amplitude a faster brain rhythm to phase slower rhythm, plays significant role in activity and has been implicated various neurological disorders. For example, Parkinson’s disease, PAC between beta (13–30 Hz) gamma (50–200 rhythms motor cortex is exaggerated, while Alzheimer’s theta (4-8 diminished. Modulating (i.e. reducing or enhancing PAC) using stimulation could therefore open new therapeutic avenues. However, it previously reported that phase-locked can increase PAC, unclear what optimal strategy modulate might be. Here, we provide theoretical framework narrow down experimental optimisation aimed at modulating which would otherwise rely on trial error. Approach We make analytical predictions Stuart-Landau model, confirm these more realistic model coupled neural populations. Main results Our specifies critical Fourier coefficients waveform should be tuned optimally PAC. Depending characteristics response curve fast population, components may include slow frequency, combinations these, as well their harmonics. also show balance energy depends relative strength endogenous rhythms, alignment with change throughout cycle. Furthermore, identify conditions requiring phase-lock and/or rhythms. Significance Together, our lays foundation for guiding development innovative effective benefit.

Language: Английский

Citations

0
Physiological effects of dual target DBS in an individual with Parkinson’s Disease and a sensing-enabled pulse generator DOI Creative Commons
Daniel D. Cummins, Stephanie S. Sandoval-Pistorius, Stephanie Cernera

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 27, 2024

Abstract Introduction Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus (GP) is an established therapy for Parkinson’s disease (PD). Novel DBS devices can record local field potential (LFP) physiomarkers from STN GP. While beta (13-30 Hz) and gamma (40-90 GP LFP oscillations correlate with PD motor severity therapeutic effects treatments, STN-GP interactions in electrophysiology patients are not well characterized. Methods Simultaneous bilateral LFPs were recorded a patient who received STN-DBS GP-DBS. Power spectra each target coherence assessed various ON- OFF-levodopa states, both at rest voluntary movement. Results OFF-DBS, peaks present GP, coincident prominent coherence. Levodopa dual-target-DBS (simultaneous GP-DBS) completely suppressed Finely-tuned (FTG) activity half frequency (62.5Hz) was seen during GP-DBS rest. To assess movement on FTG activity, we instructed We observed contralateral body movements while ON-levodopa. No dual-target-DBS. Conclusion Dual-target-DBS levodopa throughout basal ganglia induced by presence This STN-FTG GP-FTG corresponded least severe bradykinesia state, suggesting pro-kinetic role FTG.

Language: Английский

Citations

0
A phenomenological model of deep brain stimulation induced finely tuned gamma oscillations in the subthalamic nucleus DOI Creative Commons
Maximilian Scherer, David Crompton, Luka Milosevic

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(2), P. 485 - 487

Published: March 1, 2024

Language: Английский

Citations

0
Response of neuronal populations to phase-locked stimulation: model-based predictions and validation DOI Creative Commons
Nima Mirkhani, Colin G. McNamara, Gaspard Oliviers

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Background Modulation of neuronal oscillations holds promise for the treatment neurological disorders. Nonetheless, stimulating populations in a continuous open-loop manner can lead to side effects and suboptimal efficiency. Closed-loop strategies such as phase-locked stimulation aim address these shortcomings by offering more targeted modulation. While theories have been developed understand neural response stimulation, their predictions not thoroughly tested using experimental data. Objective We aimed test mathematical model regarding stimulation. Methods Using coupled oscillator model, we expanded on two key describing function phase amplitude ongoing activity. To investigate predictions, analyzed electrocorticogram (ECoG) recordings from previously conducted study Parkinsonian rats, extracted corresponding curves. Results demonstrated that is strongly correlated derivative ( ρ > 0.8) all animals except one, thereby validating prediction. The second prediction postulated becomes ineffective when network synchrony high, trend appeared missing Our analysis explained this discrepancy showing rats did reach level which theory would predict Conclusions results highlight potential fine-tuning paradigms informed models consider both oscillation.

Language: Английский

Citations

0