Vagus nerve stimulation: a physical therapy with promising potential for central nervous system disorders DOI Creative Commons
Chaoran Wang, Bangqi Wu,

Ruolan Lin

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

The diseases of the central nervous system (CNS) often cause irreversible damage to human body and have a poor prognosis, posing significant threat health. They brought enormous burdens society healthcare systems. However, due complexity their causes mechanisms, effective treatment methods are still lacking. Vagus nerve stimulation (VNS), as physical therapy, has been utilized in various diseases. VNS shown promising outcomes some CNS approved by Food Drug Administration (FDA) United States for epilepsy depression. Moreover, it demonstrated potential stroke, consciousness disorders, Alzheimer’s disease. Nevertheless, exact efficacy VNS, its beneficiaries, mechanisms action remain unclear. This article discusses current clinical evidence supporting diseases, providing updates on progress, potential, producing effects

Language: Английский

Vagus nerve stimulation as a predictive coding modulator that enhances feedforward over feedback transmission DOI Creative Commons

Shinichi Kumagai,

Tomoyo Isoguchi Shiramatsu, Kensuke Kawai

et al.

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 19

Published: April 14, 2025

Vagus nerve stimulation (VNS) has emerged as a promising therapeutic intervention across various neurological and psychiatric conditions, including epilepsy, depression, stroke rehabilitation; however, its mechanisms of action on neural circuits remain incompletely understood. Here, we present novel theoretical framework based predictive coding that conceptualizes VNS effects through differential modulation feedforward feedback circuits. Based recent evidence, propose shifts the balance between processing multiple neuromodulatory systems, resulting in enhanced signal transmission. This integrates anatomical pathways, receptor distributions, physiological responses to explain influence dynamics different spatial temporal scales. may facilitate plasticity adaptive behavior acetylcholine noradrenaline (norepinephrine), which differentially modulate signaling. mechanistic understanding serves basis for interpreting cognitive outcomes clinical conditions. Our perspective provides unified circuit-specific suggests new directions investigating their mechanisms.

Language: Английский

Citations

0
Potentiation of the muscarinic acetylcholine receptor 1 modulates neurophysiological features in a mouse model of Rett syndrome DOI Creative Commons
Hong‐Wei Dong,

Kelly Weiss,

Kathryn Baugh

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(4), P. e00384 - e00384

Published: June 15, 2024

Language: Английский

Citations

2
Vagus nerve stimulation: a physical therapy with promising potential for central nervous system disorders DOI Creative Commons
Chaoran Wang, Bangqi Wu,

Ruolan Lin

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

The diseases of the central nervous system (CNS) often cause irreversible damage to human body and have a poor prognosis, posing significant threat health. They brought enormous burdens society healthcare systems. However, due complexity their causes mechanisms, effective treatment methods are still lacking. Vagus nerve stimulation (VNS), as physical therapy, has been utilized in various diseases. VNS shown promising outcomes some CNS approved by Food Drug Administration (FDA) United States for epilepsy depression. Moreover, it demonstrated potential stroke, consciousness disorders, Alzheimer’s disease. Nevertheless, exact efficacy VNS, its beneficiaries, mechanisms action remain unclear. This article discusses current clinical evidence supporting diseases, providing updates on progress, potential, producing effects

Language: Английский

Citations

1