Transcutaneous auricular vagus nerve stimulation as a novel therapy connecting the central and peripheral systems: a review
Ningyi Zou,
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Qing Zhou,
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Yuzhengheng Zhang
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et al.
International Journal of Surgery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 9, 2024
Currently,
clinical
practice
and
scientific
research
mostly
revolve
around
a
single
disease
or
system,
but
the
disease-oriented
diagnostic
therapeutic
paradigm
needs
to
be
revised.
This
review
describes
how
transcutaneous
auricular
vagus
nerve
stimulation
(taVNS),
novel
non-invasive
neuromodulation
approach,
connects
central
peripheral
systems
of
body.
Through
widely
distributed
from
head
abdominal
cavity,
this
therapy
can
improve
treat
system
disorders,
central-peripheral
comorbidities
caused
by
autonomic
dysfunction.
In
past,
on
taVNS
has
focused
treatment
disorders
modulating
brain
nerve.
As
innervates
heart,
lungs,
liver,
pancreas,
gastrointestinal
tract,
spleen
other
organs,
could
have
an
overall
modulatory
effect
region
body
where
is
widespread.
Based
physiological
basis,
authors
summarize
existing
evidence
ability
regulate
cardiac
function,
adiposity,
glucose
levels,
immune
among
others,
diseases,
complex
diseases
with
comorbidities.
shows
successful
examples
progress
using
mechanisms
more
perspectives,
demonstrating
expanded
scope
value
provide
new
ideas
approaches
for
holistic
both
perspectives.
Language: Английский
Progress on Direct Regulation of Systemic Immunity by the Central Nervous System
World Neurosurgery,
Journal Year:
2025,
Volume and Issue:
196, P. 123814 - 123814
Published: March 26, 2025
This
article
reviews
the
research
progress
on
direct
regulation
of
immune
system
by
central
nervous
system.
The
traditional
"neuro-endocrine-immune"
network
model
has
confirmed
close
connection
between
and
However,
due
to
complex
mediating
role
endocrine
system,
its
application
in
clinical
treatment
is
limited.
In
recent
years,
peripheral
through
provided
new
methods
for
neuro-immune
related
diseases.
analyzes
changes
after
injury
summarizes
effects
various
stimulation
methods,
including
transcranial
magnetic
(TMS),
electrical
(TES),
deep
brain
(DBS),
spinal
cord
stimulation(SCS),
vagus
nerve
stimulation(VNS),
system(Figure1).
Additionally,
it
explores
future
development
directions
these
methods.
It
proposed
that
neural
techniques
exhibit
positive
reducing
inflammation,
protecting
cells
organ
functions,
improving
immunosuppressive
states,
providing
perspectives
therapeutic
potential
immune-related
Language: Английский
Increased seizure susceptibility in the collagen-induced arthritis mouse model depends on neuronal IL-1R1
Shengyu Chen,
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Rongrong Chen,
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Mengxian Luo
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et al.
Life Sciences,
Journal Year:
2025,
Volume and Issue:
369, P. 123537 - 123537
Published: March 5, 2025
Language: Английский
Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: a randomized trial
Zhiyu Yin,
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Jing Wang,
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Wei Pan
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et al.
Annals of Medicine,
Journal Year:
2025,
Volume and Issue:
57(1)
Published: March 10, 2025
Objective
This
study
aims
to
evaluate
the
effectiveness
of
transcutaneous
auricular
vagus
nerve
stimulation
(taVNS)
on
postoperative
pain
in
patients
following
perianal
surgery.
Language: Английский
Study on the Vocal Fold Movement Characteristics of Canine Models With Nerve Paralysis Caused by Different Site Injuries
Mei Shi,
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Linlin Lan,
No information about this author
Peiyun Zhuang
No information about this author
et al.
World Journal of Otorhinolaryngology - Head and Neck Surgery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
Language: Английский
Feasibility and effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in awake mice
Yu‐Mei Yu,
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Rui Yao,
No information about this author
Zhouliang Liu
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et al.
CNS Neuroscience & Therapeutics,
Journal Year:
2024,
Volume and Issue:
30(9)
Published: Sept. 1, 2024
Transcutaneous
auricular
vagus
nerve
stimulation
(taVNS)
is
widely
used
to
treat
a
variety
of
disorders
because
it
noninvasive,
safe,
and
well
tolerated
by
awake
patients.
However,
long-term
repetitive
taVNS
difficult
achieve
in
mice.
Therefore,
developing
new
method
that
fully
mimics
the
clinical
settings
well-tolerated
mice
greatly
important
for
generalizing
research
findings
related
effects
taVNS.
The
study
aimed
develop
device
use
test
its
reliability
effectiveness.
Language: Английский
Impact of optimized transcutaneous auricular vagus nerve stimulation on cardiac autonomic profile in healthy subjects and heart failure patients
Physiological Measurement,
Journal Year:
2024,
Volume and Issue:
45(7), P. 075007 - 075007
Published: July 1, 2024
To
determine
the
optimal
frequency
and
site
of
stimulation
for
transcutaneous
vagus
nerve
(tVNS)
to
induce
acute
changes
in
autonomic
profile
(heart
rate
(HR),
heart
variability
(HRV))
healthy
subjects
(HS)
patients
with
failure
(HF).
Language: Английский
The mechanisms of electrical neuromodulation
The Journal of Physiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 30, 2024
The
central
and
peripheral
nervous
systems
are
specialized
to
conduct
electrical
currents
that
underlie
behaviour.
When
this
multidimensional
system
is
disrupted
by
degeneration,
damage,
or
disuse,
externally
applied
may
act
modulate
neural
structures
provide
therapeutic
benefit.
administration
of
stimulation
can
exert
precise
multi-faceted
effects
at
cellular,
circuit
levels
restore
enhance
the
functionality
providing
an
access
route
target
specific
cells,
fibres
passage,
neurotransmitter
systems,
and/or
afferent/efferent
communication
enable
positive
changes
in
Here
we
examine
mechanisms
thought
seen
with
current
neuromodulation
technologies.
To
gain
further
insights
into
associated
stimulation,
summarize
recent
findings
from
genetic
dissection
studies
conducted
animal
models.
KEY
POINTS:
Electricity
everywhere
around
us
essential
for
how
our
nerves
communicate
within
bodies.
damaged
not
working
properly,
using
exogenous
electricity
help
improve
their
function
distinct
-
inside
individual
circuits,
across
entire
systems.
This
method
be
tailored
types
nerve
fibres,
neurotransmitters
pathways,
offering
significant
potential.
overview
explains
affects
its
potential
benefits,
based
on
research
studies.
Understanding
these
important
because
plays
a
key
role
medical
treatments
neurological
conditions.
Language: Английский
Research hotspots and trends of non-invasive vagus nerve stimulation: a bibliometric analysis from 2004 to 2023
Mingyue Chen,
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Chunlan Yang,
No information about this author
Yin Chen
No information about this author
et al.
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 19, 2024
Non-invasive
vagus
nerve
stimulation
(nVNS)
is
an
emerging
neuromodulation
technique
in
recent
years,
which
plays
a
role
nervous
system
diseases,
psychiatric
and
autoimmune
diseases.
However,
there
currently
no
comprehensive
analysis
of
all
the
literature
published
this
field.
Therefore,
article,
bibliometric
will
be
conducted
on
field
nVNS
past
20
years.
Language: Английский