Excitation/Inhibition balance relates to cognitive function and gene expression in Temporal Lobe Epilepsy: an hdEEG assessment with aperiodic exponent DOI Creative Commons
Gian Marco Duma, Simone Cuozzo, Luc Wilson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 4, 2024

Abstract Patients with epilepsy are characterized by a dysregulation of excitation-inhibition balance (E/I). The assessment E/I may inform clinicians during the diagnosis and therapy management, even though it is rarely performed. An accessible measure brain represents clinically relevant feature. Here we exploited exponent aperiodic component power spectrum EEG signal as noninvasive cost-effective proxy balance. We recorded resting-state activity high-density from 65 patients temporal lobe (TLE) 35 controls. extracted fit source-reconstructed tested differences between TLE Spearman’s correlation was performed clinical variables (age onset, duration neuropsychology) cortical expression epilepsy-related genes derived Human Allen Brain Atlas. showed significantly larger exponent, corresponding to an inhibition directed balance, in bilateral frontal regions. Lower left entorhinal, dorsolateral prefrontal cortices corresponded lower performance short term verbal memory. Limited TLE, detected significant GABRA1, GRIN2A, GABRD, GABRG2, KCNA2and PDYN. maps non-invasively reveals tight relationship altered patterns, cognition genetics.

Language: Английский

Cortical excitability and the aging brain: toward a biomarker of cognitive resilience DOI Creative Commons
Sara Palermo, Chiara Di Fazio, Eugenio Scaliti

et al.

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

This perspective article addresses the potential use of cortical excitability (CE) as an indicator cognitive health in aging people. Changes CE may be considered a sign resilience to decline old age. The authors describe research on and its link function older adults emphasize that it is promising, non-invasive measure healthy aging. They also address current challenges implementation, need for standardized measurement protocols possible future avenues research. If properly considered, could pave way early detection facilitate targeted interventions promote resilience.

Language: Английский

Citations

3
Cenobamate modulates EEG cortical activity and connectivity in individuals with drug-resistant epilepsy: a pharmaco-EEG study DOI Creative Commons
Giovanni Assenza,

B. Sancetta,

Lorenzo Ricci

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: March 3, 2025

Objective Quantitative electroencephalography (qEEG) metrics are demonstrated to correlate with and predict clinical response in individuals epilepsy. Cenobamate is an effective anti-seizure medication recently approved as add-on therapy for epilepsy, but its effects on qEEG unknown. We aimed evaluate the modulation of induced by cenobamate relationship response. Methods performed a prospective study cohort 18 epilepsy (8 women, 47 ± 16 years old) 25 healthy subjects (HS). They underwent 19-channel EEG before 6 months after administration. Power spectral density (PSD) phase locking value (PLV) delta, theta, alpha, beta, gamma frequency bands were calculated. Correlation analysis covariance exhibited significant cenobamate-induced changes their seizure changes. A regression was association responders. Results total 11 out (69%, 2 dropping out) responders (≥50% reduction). did not modify any PSD parameter PLV levels ( p < 0.01). decrease correlated reduction 0.03). Regression showed strong between responsiveness (a sensitivity 0.75, specificity 0.84, accuracy 0.81). Conclusion induces connectivity that highly associated Significance Connectivity pharmaco-EEG can provide new hints toward development innovative biomarkers precision medicine

Language: Английский

Citations

2
Excitation/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent DOI Creative Commons
Gian Marco Duma, Simone Cuozzo, Luc Wilson

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 6(4)

Published: Jan. 1, 2024

Patients with epilepsy are characterized by a dysregulation of excitation/inhibition balance (E/I). The assessment E/I may inform clinicians during the diagnosis and therapy management, even though it is rarely performed. An accessible measure brain represents clinically relevant feature. Here, we exploited exponent aperiodic component power spectrum electroencephalography (EEG) signal, as non-invasive cost-effective proxy balance. We recorded resting-state activity high-density EEG from 67 patients temporal lobe 35 controls. extracted fit source-reconstructed tested differences between Spearman's correlation was performed clinical variables (age onset, duration neuropsychology) cortical expression epilepsy-related genes derived Allen Human Brain Atlas. showed significantly larger exponent, corresponding to inhibition-directed balance, in bilateral frontal regions. Lower left entorhinal dorsolateral prefrontal cortices corresponded lower performance short-term verbal memory. Limited epilepsy, detected significant

Language: Английский

Citations

9
Gauging and controlling excitability in cortical disorders DOI
Cecilia Friedrichs‐Maeder, Grégory Lepeu, Maxime O. Baud

et al.

Current Opinion in Neurology, Journal Year: 2025, Volume and Issue: 38(2), P. 140 - 150

Published: Feb. 17, 2025

Cortical excitability, defined as the cortex's responsiveness to incoming stimuli, is a fundamental concept in neuroscience and targetable mechanism for controlling brain dysfunctions such epilepsy, well other neurological psychiatric disorders. In this review, we delineate boundaries between physiological pathological highlighting recent theoretical, experimental, translational advances relevant human Specifically, describe dynamic regulation of cortical excitability propose practical means monitor its known fluctuations guide therapeutic interventions. From conceptual standpoint, last decade research on has benefited from dynamical systems theory, which studies behavior nonlinear (here, cortex) their resilience perturbations different conditions variable excitability). We review how relationships were verified series studies. also natural these may open windows vulnerability expression dysfunctions. then turn practicalities measuring monitoring latent that must be actively probed. Practical gauging likely have broad applicability. To enable new developments clinical practice, principled design pharmacological neurostimulation therapies leverage current understanding dynamics.

Language: Английский

Citations

0
Closed-loop control of theta oscillations enhances human hippocampal network connectivity DOI Creative Commons
James E. Kragel, Sarah M Lurie, Naoum P. Issa

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 30, 2025

Theta oscillations are implicated in regulating information flow within cortico-hippocampal networks to support memory and cognition. However, causal evidence tying theta network communication humans is lacking. Here we report experimental findings using a closed-loop, phase-locking algorithm apply direct electrical stimulation neocortical nodes of the hippocampal precisely timed ongoing rhythms human neurosurgical patients. We show that repetitive lateral temporal cortex synchronized increases while it delivered, suggesting entrainment neural activity. After stimulation, connectivity persistently increased relative baseline, as indicated by theta-phase synchrony hippocampus neocortex amplitudes evoked response isolated stimulation. These indicators not affected control delivered with approximately same rhythm but without phase locking theta. role routing signals across suggest phase-synchronized promising method modulate theta- hippocampal-dependent behaviors.

Language: Английский

Citations

0
TMS-EEG evidence links random exploration to inhibitory mechanisms in the dorsolateral prefrontal cortex DOI Creative Commons
Mojtaba Chizari, Keivan Navi, Reza Khosrowabadi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Adaptive decision-making in uncertain environments requires balancing exploration and exploitation. Computational models distinguish between directed exploration, involving deliberate information-seeking, random characterized by stochastic variability. The neural correlates of these strategies have been investigated previous studies. However, while prior research implicates the dorsolateral prefrontal cortex (DLPFC) its underlying excitatory inhibitory mechanisms remain unclear. Understanding processes is essential for explaining how individuals adapt to a dynamic environment. To investigate this, we combined transcranial magnetic stimulation (TMS) with electroencephalography (EEG) directly assess cortical functions. Twenty-five healthy participants completed Horizon Task, behavioral paradigm designed dissociate after task, they received single-pulse TMS over DLPFC. TMS-evoked potentials (TEPs) N45, P60, N100 were examined as neurophysiological markers GABAA, GABAB, glutamate activity. Results revealed significant positive correlation amplitude at right DLPFC suggesting that GABAB-mediated inhibition plays key role decision-making. Additionally, decision noise parameter logistic model further validated this association. These findings highlight importance exploratory behavior underscore utility TMS-EEG uncovering adaptive

Language: Английский

Citations

0
Modulating cortical excitability and cortical arousal by pupil self-regulation DOI Creative Commons
Marieke Lieve Weijs, Silvia Missura, Weronika Potok

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 16, 2025

The brain's arousal state (i.e., central arousal) is regulated by multiple neuromodulatory nuclei in the brainstem and significantly influences high-level cognitive processes. By exploiting mechanistic connection between locus coeruleus, a key regulator of arousal, pupil dynamics, we recently demonstrated that participants could gain volitional control over arousal-regulating centers including coeruleus using pupil-based biofeedback approach. Here, test whether modulates electrophysiological markers cortical excitability, P300 responses. Combining with single-pulse transcranial magnetic stimulation, electroencephalography, an auditory oddball task reveals three main results: self-regulation (i) (ii) electroencephalogram spectral slope, marker (iii) response to target tones, event-related potential suggested be linked phasic activity. show fundamental aspects brain function. Whether this method can further used modulate these case disturbances associated neurological psychiatric disorders needs investigated future studies.

Language: Английский

Citations

0
The Neurophysiological Effects of Theta Burst Stimulation as Measured by Electroencephalography: A Systematic Review DOI Creative Commons
Bridgette E. Speranza, Aron T. Hill, Michael Do

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(11), P. 1083 - 1120

Published: July 29, 2024

Theta burst stimulation (TBS) is a non-invasive brain technique that can modulate neural activity. The effect of TBS on regions beyond the motor cortex remains unclear. With increased interest in applying to non-motor for research and clinical purposes, these effects must be understood characterised. We synthesised electrophysiological single session TBS, as indexed by electroencephalography (EEG) concurrent transcranial magnetic EEG (TMS-EEG), non-clinical participants. reviewed 79 studies administered either continuous (cTBS) or intermittent (iTBS) protocols. Broadly, cTBS suppressed iTBS facilitated evoked response component amplitudes. Response measured spectral power connectivity was much more variable. Variability presence task stimuli. There large degree heterogeneity methodology across studies. Additionally, individual differences insufficiently investigated. Future investigating consider methodological factors may affect outcomes.

Language: Английский

Citations

2
Effects of one-week bilateral cerebellar iTBS on resting-state functional brain network and multi-task attentional performance in healthy individuals: A randomized, sham-controlled trial DOI Creative Commons
Meiliang Liu, Chao Yu,

Jinping Shi

et al.

NeuroImage, Journal Year: 2024, Volume and Issue: 295, P. 120648 - 120648

Published: May 17, 2024

Cerebellar intermittent theta burst stimulation (iTBS) modulates the excitability of cerebral cortex and may enhance attentional performance. To date, few studies have conducted iTBS on healthy subjects for one week used electroencephalography (EEG) to investigate effect multiple sessions resting-state functional brain networks daily

Language: Английский

Citations

1
mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration DOI Creative Commons
Inês Dias, Christian R. Baumann, Daniela Noaín

et al.

Sleep Medicine, Journal Year: 2024, Volume and Issue: 124, P. 704 - 716

Published: Nov. 9, 2024

Language: Английский

Citations

1