Published: Dec. 9, 2024

Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) its ability promote brain plasticity, taVNS has emerged a promising therapeutic option for SAH patients. However, effects on cardiovascular dynamics in critically ill patients, like those with SAH, have not yet been investigated. association between cardiac elevated risk poor clinical outcomes after it essential characterize ensure this approach safe fragile population. Therefore, we assessed impact both acute repetitive function study.In randomized trial, 24 patients were assigned either treatment or Sham group. During their stay intensive care unit, monitored patient electrocardiogram (ECG) readings vital signs. We compared long-term changes heart rate, rate variability, QT interval, blood pressure two groups. Additionally, comparing metrics before, during, intervention. also explored biomarkers exhibiting improvement.We found that did significantly alter pressure, intracranial pressure. increased overall variability parasympathetic activity sham treatment. The increase was most pronounced from 2–4 days initial (Cohen’s d = 0.50). Acutely, peripheral perfusion index without affecting corrected variability. post-treatment elevation more who experienced decrease than one point Modified Rankin Score at time discharge.Our study induce adverse effects, bradycardia prolongation, supporting development immunomodulatory observed may serve biomarker could derive greater benefit treatment.NCT04557618

Language: Английский