Dynamic changes in human brain connectivity following ultrasound neuromodulation DOI Creative Commons
Cyril Atkinson-Clément,

Mohammad Alkhawashki,

Marilyn Gatica

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 3, 2024

Abstract Non-invasive neuromodulation represents a major opportunity for brain interventions, and transcranial focused ultrasound (FUS) is one of the most promising approaches. However, some challenges prevent community from fully understanding its outcomes. We aimed to address them unravel temporal dynamics FUS effects in humans. Twenty-two healthy volunteers participated study. Eleven received right inferior frontal cortex while other 11 were stimulated thalamus. Using dynamic approach, we compared resting-state fMRI seed-based functional connectivity obtained before after FUS. also assessed behavioural changes as measured with task reactive motor inhibition. Our findings reveal that are predominantly time-constrained spatially distributed regions functionally connected directly area. In addition, mediation analysis highlighted applied was associated alterations which explained by acoustic pressure change observed. study underscored biological indicative observed more than an hour following stimulation related pressure.

Language: Английский

Optimizing Transcranial Focused Ultrasound Parameters: A Methodological Advancement in Non-invasive Brain Stimulation for Next-Gen Clinical Applications DOI Creative Commons
Sachin Gupta,

Mustafa Mudhafar,

Yogini Dilip Borole

et al.

Neuroscience Informatics, Journal Year: 2025, Volume and Issue: 5(2), P. 100204 - 100204

Published: May 5, 2025

Language: Английский

Citations

0
Ablation of cervical facet joints is safe and feasible with two magnetic resonance-guided focused ultrasound transducers as demonstrated by thermal simulations DOI Creative Commons
Marta M. Iversen, Michelle A. Kline, Emily A. Smith

et al.

International Journal of Hyperthermia, Journal Year: 2025, Volume and Issue: 42(1)

Published: May 13, 2025

Chronic neck pain due to cervical facet joint degenerative disease is a leading cause of disability. Denervation the capsule with magnetic resonance-guided focused ultrasound (MRgFUS) ablation could provide noninvasive treatment option. Our study investigates safety and feasibility targeting joints two clinical transducers. We simulated MRgFUS treatments in spine six individuals using models from MR datasets segmented into eight tissue types. determined every vertebral level at different trajectories for 1 MHz Using acoustic (hybrid angular spectrum method) thermal (Pennes' bioheat equation) simulations, we reaching ablative temperatures targets while avoiding damage off-target locations. Both transducers produce or near-ablative target maintaining quantified temperature during 20-second sonication important surrounding structures including spinal nerves, cord, CSF, major arteries. Temperatures critical demonstrated less than 3 °C rise, which well within safety. Ablative doses were achieved (>240 CEM 43 °C). This simulation demonstrates capsules clinically available Integrating these an device introduces novel modality treat pain.

Language: Английский

Citations

0
The role of hemispheric sensory shifts: Impacts on stretch reflex and motor plasticity post-stroke DOI Creative Commons
Maryam Darvish,

Joohwan Sung,

Jordan N. Williamson

et al.

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111653 - 111653

Published: May 1, 2025

Language: Английский

Citations

0
Dynamic changes in human brain connectivity following ultrasound neuromodulation DOI Creative Commons
Cyril Atkinson-Clément,

Mohammad Alkhawashki,

Marilyn Gatica

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 3, 2024

Abstract Non-invasive neuromodulation represents a major opportunity for brain interventions, and transcranial focused ultrasound (FUS) is one of the most promising approaches. However, some challenges prevent community from fully understanding its outcomes. We aimed to address them unravel temporal dynamics FUS effects in humans. Twenty-two healthy volunteers participated study. Eleven received right inferior frontal cortex while other 11 were stimulated thalamus. Using dynamic approach, we compared resting-state fMRI seed-based functional connectivity obtained before after FUS. also assessed behavioural changes as measured with task reactive motor inhibition. Our findings reveal that are predominantly time-constrained spatially distributed regions functionally connected directly area. In addition, mediation analysis highlighted applied was associated alterations which explained by acoustic pressure change observed. study underscored biological indicative observed more than an hour following stimulation related pressure.

Language: Английский

Citations

2