A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies
Tae‐Hee Kim,
No information about this author
Seong‐Yeong Heo,
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Pathum Chandika
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et al.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(2), P. e24216 - e24216
Published: Jan. 1, 2024
Periodontitis
is
a
common
chronic
inflammatory
disease
of
the
supporting
tissues
tooth
that
involves
complex
interaction
microorganisms
and
various
cell
lines
around
infected
site.
To
prevent
treat
this
disease,
several
options
are
available,
such
as
scaling,
root
planning,
antibiotic
treatment,
dental
surgeries,
depending
on
stage
disease.
However,
these
treatments
can
have
side
effects,
including
additional
responses,
wounds,
need
for
secondary
surgery.
Consequently,
numerous
studies
focused
developing
new
therapeutic
agents
more
effective
periodontitis
treatment.
This
review
explores
latest
trends
in
bioactive
substances
with
effects
using
search
engines.
Therefore,
study
aimed
to
suggest
directions
approaches.
Additionally,
we
provide
summary
current
applications
underlying
mechanisms
substances,
which
serve
reference
development
treatments.
Language: Английский
Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 17 - 17
Published: Jan. 3, 2025
Background
Honey,
a
natural
product
with
diverse
bioactive
compounds,
has
been
increasingly
explored
for
its
potential
anticancer
properties.
This
study
aims
to
comprehensively
analyze
the
scientific
literature
on
relationship
between
honey
and
breast
cancer.
Methods
A
bibliometric
analysis
was
conducted
using
ScienceDirect
database
identify
publications
from
2014
2024.
Data
publication
trends,
author
collaboration,
keyword
were
extracted
gain
insight
into
research
landscape.
Keyword
identified
nine
distinct
clusters,
indicating
directions
regarding
role
of
in
cancer
treatment.
Results
Key
journals
such
as
Journal
Ethnopharmacology
Food
Chemistry
have
at
forefront
disseminating
findings
this
domain,
demonstrating
strong
interdisciplinary
approach
that
bridges
traditional
medicine
modern
inquiry.
The
increasing
interest
properties
honey,
evidenced
by
growing
number
studies,
underlines
promising
agent
prevention
Recent
advances
synthesis
theranostic
paradigms
cerium
oxide
nanoparticles
(CeONPs)
highlighted,
well
selenium
nanoconstructs.
toxicity
quality
control
Perillae
Fructus
also
highlighted.
Conclusions
provides
comprehensive
overview
current
state
knowledge
uncovers
emerging
issues
require
further
investigation.
Language: Английский
Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 17 - 17
Published: Jan. 20, 2025
Background
Honey,
a
natural
product
with
diverse
bioactive
compounds,
has
been
increasingly
explored
for
its
potential
anticancer
properties.
This
study
aims
to
comprehensively
analyze
the
scientific
literature
on
relationship
between
honey
and
breast
cancer.
Methods
A
bibliometric
analysis
was
conducted
using
ScienceDirect
database
identify
publications
from
2014
2024.
Data
publication
trends,
author
collaboration,
keyword
were
extracted
gain
insight
into
research
landscape.
Keyword
identified
nine
distinct
clusters,
indicating
directions
regarding
role
of
in
cancer
treatment.
Results
Key
journals
such
as
Journal
Ethnopharmacology
Food
Chemistry
have
at
forefront
disseminating
findings
this
domain,
demonstrating
strong
interdisciplinary
approach
that
bridges
traditional
medicine
modern
inquiry.
The
increasing
interest
properties
honey,
evidenced
by
growing
number
studies,
underlines
promising
agent
prevention
Recent
advances
synthesis
theranostic
paradigms
cerium
oxide
nanoparticles
(CeONPs)
highlighted,
well
selenium
nanoconstructs.
toxicity
quality
control
Perillae
Fructus
also
highlighted.
Conclusions
provides
comprehensive
overview
current
state
knowledge
uncovers
emerging
issues
require
further
investigation.
Language: Английский
Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 17 - 17
Published: March 24, 2025
Background
Honey,
a
natural
product
with
diverse
bioactive
compounds,
has
been
increasingly
explored
for
its
potential
anticancer
properties.
This
study
aims
to
comprehensively
analyze
the
scientific
literature
on
relationship
between
honey
and
breast
cancer.
Methods
A
bibliometric
analysis
was
conducted
using
ScienceDirect
database
identify
publications
from
2014
2024.
Data
publication
trends,
author
collaboration,
keyword
were
extracted
gain
insight
into
research
landscape.
Keyword
identified
nine
distinct
clusters,
indicating
directions
regarding
role
of
in
cancer
treatment.
Results
In
Key
journals
such
as
Journal
Ethnopharmacology
Food
Chemistry
have
at
forefront
disseminating
findings
this
domain,
demonstrating
strongly
interdisciplinary
approach
that
bridges
traditional
medicine
modern
inquiry.
The
increasing
interest
properties
honey,
evidenced
by
growing
number
studies,
underlines
promising
agent
prevention
Conclusions
provides
comprehensive
overview
current
knowledge
landscape
highlights
emerging
issues
require
further
exploration.
Language: Английский
Pharmacological and Molecular Docking Investigation of Leaves of Eriobotrya japonica: Antioxidant, Enzyme Inhibition, and Anti-Inflammatory Effects
Pao‐Jen Kuo,
No information about this author
Liting Chen,
No information about this author
Sin‐Min Li
No information about this author
et al.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 413 - 413
Published: March 29, 2025
Leaves
of
Eriobotrya
japonica
have
long
been
utilized
in
traditional
Chinese
medicine
(TCM)
for
treating
pulmonary
inflammation
and
stomach
disorders.
This
study
extends
their
pharmacological
applications
by
evaluating
the
antioxidant,
anti-α-glucosidase,
anti-acetylcholinesterase
(AChE),
anti-inflammatory
activities
solvent
extracts
isolated
bioactive
components
through
an
integrative
approach
combining
extraction,
bioassays,
molecular
docking.
Solvent
prepared
with
varying
polarities
exhibited
distinct
bioactivities,
100
°C
water
methanol
displaying
strongest
antioxidant
potential.
The
ethyl
acetate
extract
potent
α-glucosidase
inhibition,
whereas
n-hexane
demonstrated
significant
AChE
inhibitory
activity.
Among
compounds,
epicatechin
(5)
(SC50
=
7.83
±
0.34
μM)
rutin
(6)
6.69
0.25
showed
superior
ABTS
superoxide
scavenging
activities,
respectively,
compared
to
positive
controls
(BHT
cynaroside).
Ursolic
acid
(2)
stronger
inhibition
(IC50
10.68
0.76
than
acarbose
419.93
29.15
μM),
while
tormentic
(4)
chlorogenic
acid.
also
displayed
NO
20.18
1.46
comparable
quercetin
17.05
1.63
Western
blot
analysis
confirming
its
iNOS
Molecular
docking
further
supported
these
findings,
revealing
that
ursolic
binding
affinity
(−8.7
kcal/mol)
(−5.1
kcal/mol),
higher
energy
(−8.8
(−7.8
(−7.5
a
similar
(−7.7
kcal/mol).
These
results
highlight
strong
potential
E.
leaf
compounds
as
natural
antioxidants,
enzyme
inhibitors,
agents,
supporting
development
dietary
supplements
or
therapeutic
candidates
managing
oxidative
stress,
hyperglycemia,
neurodegenerative
diseases,
inflammatory
Language: Английский
Herbal Extracts in Anti-Aging Products
Advances in chemical and materials engineering book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 335 - 354
Published: Oct. 25, 2024
This
chapter
discusses
natural
compounds
recognized
for
their
antiaging
properties
and
describes
the
underlying
mechanisms
of
action,
providing
a
concise
synopsis
studies
on
efficacy
herbal
extracts
in
products.
The
potential
certain
extracts,
such
as
green
tea,
ginkgo,
licorice,
Aloe
vera,
ginseng,
treating
various
signs
aging
has
been
investigated
response
to
growing
demand
alternatives.
Their
which
primarily
target
antioxidant
defense,
collagen
production,
cellular
repair,
explain
how
they
reduce
oxidative
stress,
improve
skin
elasticity,
promote
rejuvenation.
then
future
trends
issues
proposes
solutions.
Language: Английский