Nardostachys jatamansi Extract and Nardosinone Exert Neuroprotective Effects by Suppressing Glucose Metabolic Reprogramming and Modulating T Cell Infiltration DOI Creative Commons

Congyan Duan,

Weifang Lin,

Mingjie Zhang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 644 - 644

Published: April 28, 2025

Background: Nardostachys jatamansi DC. (Gansong), a widely utilized herb in traditional Chinese medicine, has been historically employed the management of various neuropsychiatric disorders. Nardosinone (Nar), sesquiterpenoid compound, identified as one principal bioactive constituents N. jatamansi. This study investigated effects ethyl acetate extract (NJ-1A) from and its active constituent nardosinone on neuroinflammatory mediator release, glucose metabolic reprogramming, T cell migration using both vitro vivo experimental models. Methods: Lipopolysaccharide(LPS)-induced BV-2 microglial cells 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced male C57BL/6N mouse chronic model Parkinson’s disease were applied. Results: Both NJ-1A Nar could significantly suppress LPS-induced production M1 pro-inflammatory factors or markers microglia inhibit glycolytic process promote oxidative phosphorylation via AKT/mTOR signaling pathway. Furthermore, they exhibited capacity to attenuate chemokine release activated microglia, consequently reducing migration. In experiments revealed that effectively inhibited activation, diminished infiltration, mitigated loss tyrosine hydroxylase (TH)-positive dopaminergic neurons substantia nigra MPTP-induced mice. Conclusions: exert neuroprotective through modulation polarization states, regulation suppression infiltration.

Language: Английский

Nardostachys jatamansi Extract and Nardosinone Exert Neuroprotective Effects by Suppressing Glucose Metabolic Reprogramming and Modulating T Cell Infiltration DOI Creative Commons

Congyan Duan,

Weifang Lin,

Mingjie Zhang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 644 - 644

Published: April 28, 2025

Background: Nardostachys jatamansi DC. (Gansong), a widely utilized herb in traditional Chinese medicine, has been historically employed the management of various neuropsychiatric disorders. Nardosinone (Nar), sesquiterpenoid compound, identified as one principal bioactive constituents N. jatamansi. This study investigated effects ethyl acetate extract (NJ-1A) from and its active constituent nardosinone on neuroinflammatory mediator release, glucose metabolic reprogramming, T cell migration using both vitro vivo experimental models. Methods: Lipopolysaccharide(LPS)-induced BV-2 microglial cells 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced male C57BL/6N mouse chronic model Parkinson’s disease were applied. Results: Both NJ-1A Nar could significantly suppress LPS-induced production M1 pro-inflammatory factors or markers microglia inhibit glycolytic process promote oxidative phosphorylation via AKT/mTOR signaling pathway. Furthermore, they exhibited capacity to attenuate chemokine release activated microglia, consequently reducing migration. In experiments revealed that effectively inhibited activation, diminished infiltration, mitigated loss tyrosine hydroxylase (TH)-positive dopaminergic neurons substantia nigra MPTP-induced mice. Conclusions: exert neuroprotective through modulation polarization states, regulation suppression infiltration.

Language: Английский

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