Enhancing Tumor Targeted Therapy: The Role of iRGD Peptide in Advanced Drug Delivery Systems

Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3768 - 3768

Published: Nov. 8, 2024

Chemotherapy remains the primary therapeutic approach in treating cancer. The tumor microenvironment (TME) is complex network surrounding cells, comprising various cell types, such as immune fibroblasts, and endothelial well ECM components, blood vessels, signaling molecules. often stiff dense of TME interacts dynamically with influencing cancer growth, response, metastasis, resistance to therapy. effectiveness treatment solid tumors frequently reduced due poor penetration drug, which leads attaining concentrations below levels at site. Cell-penetrating peptides (CPPs) present a promising that improves internalization agents. CPPs, are short amino acid sequences, exhibit high ability pass membranes, enabling them deliver drugs efficiently minimal toxicity. Specifically, iRGD peptide, member notable for its capacity deeply penetrate tissues by binding simultaneously integrins ανβ3/ανβ5 neuropilin receptors. Indeed, characteristically expressed allows peptide home onto cells. Notably, respective dual-receptor targeting mechanism considerably increases permeability vessels tumors, an efficient delivery co-administered or nanoparticles into mass. Therefore, facilitates deeper drug efficacy therapies. Distinctively, we will focus on action, systems their application, deliberate future perspectives developing iRGD-conjugated therapeutics. In summary, this review discusses potential overcoming barriers maximize efficiency while minimizing side effects.

Language: Английский

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Rhodamine 6G in Oxidized Sodium Alginate Polymeric Hydrogel for Photodynamically Inactivating Cancer Cells

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(35), P. 2801 - 2812

Published: Aug. 7, 2024

As cancer therapy progresses, challenges remain due to the inherent drawbacks of conventional treatments such as chemotherapy, gene therapy, radiation and surgical removal. Moreover, their associated side effects, affect both cancerous normal cells, making photodynamic (PDT) an attractive alternative.

Language: Английский

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Natural Polymer Derivative-based pH responsive Nanoformulations Entrapped Diketo-tautomers of 5-fluorouracil for Enhanced Cancer Therapy

ADMET & DMPK, Journal Year: 2025, Volume and Issue: unknown, P. 2554 - 2554

Published: Jan. 3, 2025

Despite significant advancements in cancer therapies, chemotherapeutics continue to be the mainstay for treating patients, with 5-fluorouracil (5-FU) being commonly used various cancers. However, its limited ability penetrate cell membranes and short half-life, caused by rapid metabolism, necessitate frequent administration of high doses maintain effective therapeutic levels. This study aimed synthesize oxidized sodium alginate (OSA) derivatives create OSA nanoparticles loaded 5-FU (OSANP@ 5-FU), promoting diketo tautomers, evaluate their photophysical properties, release profile, anticancer activity minimal toxicity. The investigation encompassed physicochemical characterization, encapsulation efficiency, kinetics at pH 2.2 7.4, viability assessment via MTT assay V79 cells, vitro efficacy A375 line. Steady-state absorption emission confirmed presence advantageous diketone tautomers 5-FU, indicating radiative transitions from second singlet excited state ground (S2→S0) drug's within polymeric nanostructure. Dynamic light scattering revealed that nanoparticles, initially 177.8 nm, grew 226.6 nm after encapsulating retaining zeta potential stability. With a 68% studies showed 46 54 % released across different levels 510 minutes. In acidic conditions, there is greater than neutral levels, pH-responsive profile beneficial treatment, mechanism OSANPs following Fickian diffusion as identified Korsmeyer-Peppas mathematical model formulation showing improved efficacy.

Language: Английский

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Proof of Concept for the Single-Protein Anticancer Molecule Targeting Both a Tumor Surface Antigen and an Intracellular Oncoprotein

Published: Jan. 1, 2025

Language: Английский

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Nanocarriers for cutting-edge cancer immunotherapies

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 15, 2025

Cancer immunotherapy aims to harness the body's own immune system for effective and long-lasting elimination of malignant neoplastic tissues. Owing advance in understanding cancer pathology immunology, many novel strategies enhancing immunological responses against various cancers have been successfully developed, some translated into excellent clinical outcomes. As one promising strategy next generation immunotherapies, activating multi-cellular network (MCN) within tumor microenvironment (TME) deploy multiple mechanisms action (MOAs) has attracted significant attention. To achieve this effectively safely, delivering or pleiotropic therapeutic cargoes targeted sites cancerous tissues, cells, intracellular organelles is critical, which numerous nanocarriers developed leveraged. In review, we first introduce payloads categorized according their predicted functions physicochemical structures forms. Then, nanocarriers, along with unique characteristics, properties, advantages, limitations, are introduced notable recent applications immunotherapy. Following discussions on targeting strategies, a summary each nanocarrier matching suitable provided comprehensive background information designing regimens.

Language: Английский

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Peptide-based drugs in immunotherapy: current advances and future prospects

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 23, 2025

Language: Английский

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Inhibitory Effect of Nano-Formulated Extract of Passiflora incarnata on Dalton’s Lymphoma Ascites-Bearing Swiss albino Mice

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 270 - 270

Published: Feb. 18, 2025

Background/Objectives: This study explored the antitumor effect of Passiflora incarnata leaves' nanoformulation (N-EEP) in fibroblasts, A375 cell lines, and vivo using Dalton's lymphoma ascites (DLA)-bearing mice. Methods: N-EEP treatment could significantly slow scratch closing cells compared to extract itself (EEP). Results: The hemolytic assay showed that had less than 2% hemolysis, making formulation highly biocompatible. In administration delayed tumor growth rate, reduced weight gain, increased tumor-bearing mice's life span. Furthermore, ascitic were aspirated from investigated for various gene expressions. suppressor p53, which plays a significant role mitochondrial-mediated apoptosis pathway, was found be elevated animals treated with N-EEP. We assessed cytotoxicity isolated DLA induced mice both trypan blue MTT assays, while apoptotic studies conducted Hoechst staining. Results assays indicated nearly 80% killed by (200 μg/mL). Additionally, apoptosis, characterized condensed nuclei, observed after treatment, confirming one modes death caspase-dependent apoptosis. Conclusions: Our suggests upregulating p53 expression inducing

Language: Английский

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Frustrating the Serenity of Bacterial Biofilms by Bristly Reduced Graphene Oxide Sheets

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 26, 2025

Language: Английский

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RNA Bioconjugation: Current Development in siRNA Therapeutics

Published: Jan. 1, 2025

Language: Английский

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Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Liposomes Loaded with STING Agonist Enhances Immune Activation for Breast Cancer Immunotherapy

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3657 - 3657

Published: Oct. 30, 2024

Pharmacologically targeting the STING pathway offers a novel approach to cancer immunotherapy. However, small-molecule agonists face challenges such as poor tumor accumulation, rapid clearance, and short-lived effects within microenvironment, thus limiting their therapeutic potential. To address of specificity inadequate in breast treatment, herein, we report design development targeted liposomal delivery system modified with tumor-targeting peptide iRGD (iRGD-STING-PFP@liposomes). With LIFU irradiation, exploits acoustic cavitation, where gas nuclei form collapse hydrophobic region liposome lipid bilayer (transient pore formation), which leads significantly enhanced drug release.

Language: Английский

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