The persistent challenge of ischemic stroke burden from high fasting plasma glucose: a global perspective DOI Creative Commons
Zhenhai Sun,

Menghe Zhang,

Yaoyao Zuo

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 6, 2025

Ischemic stroke is a leading cause of disability and mortality worldwide, with high fasting plasma glucose (HFPG) recognized as critical modifiable risk factor. This study aimed to evaluate the global disease burden ischemic attributable HFPG predict trends over next 15 years. We utilized comparative assessment method from Global Burden Disease (GBD) 2021 quantify in terms deaths, Disability-Adjusted Life Years (DALYs), their age-standardized rates. The estimated annual percent changes (EAPCs) were calculated temporal trends. Additionally, our analysis included health inequality analysis, decomposition predictive employing Bayesian Age-Period-Cohort model (BAPC). In 2021, deaths DALYs due 659,378 (95% UI: 507,502 823,945) 12,371,434 9,587,506 15,382,662), respectively. Notably, both figures have doubled since 1990. Over past 30 years, rate (ASMR) DALY (ASDR) experienced significant decline, EAPC -0.96 CI: -1.05 -0.86) -0.72 -0.81 -0.62), High-middle middle Socio-Demographic Index (SDI) regions represented primary locations burden, while this gradually shifting towards low SDI regions. Furthermore, was more men than women pronounced middle-aged elderly populations compared younger individuals. Population growth aging principal factors contributing increasing burden. projections indicate that will exhibit downward trend For ASMR ASDR shown resulting continue rise globally. underscores persistent public challenge posed by associated HFPG. Future targeted medical strategies should prioritize beyond those High SDI, especially concentrating on individuals male patients.

Language: Английский

The persistent challenge of ischemic stroke burden from high fasting plasma glucose: a global perspective DOI Creative Commons
Zhenhai Sun,

Menghe Zhang,

Yaoyao Zuo

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 6, 2025

Ischemic stroke is a leading cause of disability and mortality worldwide, with high fasting plasma glucose (HFPG) recognized as critical modifiable risk factor. This study aimed to evaluate the global disease burden ischemic attributable HFPG predict trends over next 15 years. We utilized comparative assessment method from Global Burden Disease (GBD) 2021 quantify in terms deaths, Disability-Adjusted Life Years (DALYs), their age-standardized rates. The estimated annual percent changes (EAPCs) were calculated temporal trends. Additionally, our analysis included health inequality analysis, decomposition predictive employing Bayesian Age-Period-Cohort model (BAPC). In 2021, deaths DALYs due 659,378 (95% UI: 507,502 823,945) 12,371,434 9,587,506 15,382,662), respectively. Notably, both figures have doubled since 1990. Over past 30 years, rate (ASMR) DALY (ASDR) experienced significant decline, EAPC -0.96 CI: -1.05 -0.86) -0.72 -0.81 -0.62), High-middle middle Socio-Demographic Index (SDI) regions represented primary locations burden, while this gradually shifting towards low SDI regions. Furthermore, was more men than women pronounced middle-aged elderly populations compared younger individuals. Population growth aging principal factors contributing increasing burden. projections indicate that will exhibit downward trend For ASMR ASDR shown resulting continue rise globally. underscores persistent public challenge posed by associated HFPG. Future targeted medical strategies should prioritize beyond those High SDI, especially concentrating on individuals male patients.

Language: Английский

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