Lung Cancer 2020

Clinics in Chest Medicine, Journal Year: 2020, Volume and Issue: 41(1), P. 1 - 24

Published: Jan. 31, 2020

Language: Английский

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The microbiome, cancer, and cancer therapy

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(3), P. 377 - 388

Published: March 1, 2019

Language: Английский

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Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 16, 2023

Abstract Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in human health. An altered microbiome can be associated with complex diseases. Intratumoral microbial components are found multiple tumor tissues closely correlated cancer initiation development therapy efficacy. The intratumoral microbiota may contribute to promotion of the progression cancers by DNA mutations, activating carcinogenic pathways, promoting chronic inflammation, complement system, initiating metastasis. Moreover, not only enhance antitumor immunity via mechanisms STING signaling activation, T NK cell TLS production, microbiota-derived antigen presenting, but also decrease immune responses promote through pathways upregulation ROS, an anti-inflammatory environment, inactivation, immunosuppression. effect on is dependent composition, crosstalk between cancer, status cancers. regulate physiology response different β-catenin, TLR, ERK, NF-κB, STING, among others. These viewpoints help identify as diagnosis or prognosis evaluation cancers, new therapeutic strategy potential targets for therapy.

Language: Английский

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Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored

Cells, Journal Year: 2019, Volume and Issue: 8(4), P. 293 - 293

Published: March 29, 2019

Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant composition the microbiome, characterizes breast cancer. In this review we discuss changes to metabolism cells, as well and gut microbiome in The role unresolved, nevertheless it seems that does have pathology disease. secretes bioactive metabolites (reactivated estrogens, short chain fatty acids, amino acid metabolites, or secondary bile acids) modulate We highlight bacterial species taxonomical units generate these show their mode action, how affect mitochondrial other molecular events These resemble human hormones, they are produced "gland" (in case, microbiome) subsequently transferred distant sites action through circulation. appear be important constituents tumor microenvironment. Finally, dysbiosis interferes with treatment interfering chemotherapeutic drug availability.

Language: Английский

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Tumor biomarkers for diagnosis, prognosis and targeted therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 20, 2024

Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.

Language: Английский

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The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy

Cellular and Molecular Life Sciences, Journal Year: 2020, Volume and Issue: 77(14), P. 2739 - 2749

Published: Jan. 23, 2020

Abstract Like other body districts, lungs present a complex bacteria community. An emerging function of lung microbiota is to promote and maintain state immune tolerance, prevent uncontrolled not desirable inflammatory response caused by inhalation harmless environmental stimuli. This effect mediated continuous dialog between commensal cells resident in lungs, which express repertoire sensors able detect microorganisms. The same receptors are also involved the recognition pathogens mounting proper response. Due its important role preserving homeostasis, can be considered mirror health status. Indeed, several studies indicate that bacterial composition drastically changes during occurrence pulmonary pathologies, such as cancer, available data suggest modifications part etiology tumors influence their progression therapy. These results provide scientific rationale analyze biomarker for cancer consider new potential target therapeutic intervention reprogram antitumor microenvironment. In review, we discussed about physiology summarized most relevant relationship cancer.

Language: Английский

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Role of lung and gut microbiota on lung cancer pathogenesis

Journal of Cancer Research and Clinical Oncology, Journal Year: 2021, Volume and Issue: 147(8), P. 2177 - 2186

Published: May 20, 2021

Abstract Background Lung cancer is the leading cause of cancer-related deaths worldwide (Ferlay et al., Int J Cancer 136:E359–386, 2015). In addition, lung associated with highest mortality among all types (Wu Exp Ther Med 16:3004–3010, 2018). Previous studies report that microbiota play an important role in cancer. Notably, changes and gut microbiota, are progression Several microbiome promote initiation development by modulating metabolic pathways, inhibiting function immune cells, producing pro-inflammatory factors. some factors such as dysbiosis, affect production bacteriotoxins, genotoxicity virulence effect, therefore, they a key progression. These findings imply potential markers targets for However, has not been fully explored. Purpose The aim this study was to systemically review recent research on relationship we explored gut–lung axis mechanisms Conclusion Pulmonary intestinal flora influence occurrence, development, treatment prognosis cancer, will provide novel strategies prevention, diagnosis,

Language: Английский

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Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening

Antibiotics, Journal Year: 2021, Volume and Issue: 10(4), P. 401 - 401

Published: April 7, 2021

Antibiotics are considered as a cornerstone of modern medicine and their discovery offers the resolution to infectious diseases problem. However, excessive use antibiotics worldwide has generated critical public health issue bacterial resistance correlated with inefficiency is still unsolved. Finding novel therapeutic approaches overcome imperative, natural compounds antibacterial effects could be promising option. The role played by in tumorigenesis interrelation microbiota debatable far from being elucidated. Thus, present manuscript global perspective on terms evolution historical an emphasis main classes adverse effects. It also highlights connection between microbiota, focusing dual tumorigenesis. In addition, using properties potential alternatives for classical antibiotic therapy discussed.

Language: Английский

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Lung microbiome: new insights into the pathogenesis of respiratory diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 17, 2024

The lungs were long thought to be sterile until technical advances uncovered the presence of lung microbial community. microbiome healthy is mainly derived from upper respiratory tract (URT) but also has its own characteristic flora. selection mechanisms in lung, including clearance by coughing, pulmonary macrophages, oscillation cilia, and bacterial inhibition alveolar surfactant, keep transient mobile, which different other organs. bacteriome been intensively studied recently, relatively little research focused on mycobiome virome. This up-to-date review retrospectively summarizes microbiome's history, composition, function. We focus interaction with oropharynx gut emphasize role it plays innate adaptive immune responses. More importantly, we multiple diseases, asthma, chronic obstructive disease (COPD), fibrosis, bronchiectasis, pneumonia. impact coronavirus 2019 (COVID-19) cancer comprehensively studied. Furthermore, summarizing therapeutic potential diseases examining shortcomings field, propose an outlook direction research.

Language: Английский

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Gut microbiota: A new insight into lung diseases

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113810 - 113810

Published: Oct. 8, 2022

The human gut microbiota is a complex ecosystem involved in the metabolism, immunity, and health of host. microbiome plays key role development host's innate adaptive immune system, while system orchestrates maintenance host-microbe symbiosis. Lung diseases are usually accompanied by dysbiosis intestinal flora an immune-inflammatory response. its metabolites directly or indirectly regulation host lung disease. However, exact mechanism action gut-lung axis crosstalk remains unclear. This review aimed to summarize latest advances their typical diseases, such as pulmonary hypertension, COPD, cancer. Especially COVID-19, problem troubling world, also discussed it. Moreover, it concentrated on mechanisms between identified specific link among microbiota, metabolites, regulation, which could be used breakthrough find new targets for some without therapeutic drugs clinic. It tool "drug-bacterial interaction" potential applications would provide clear direction future research propose strategy targeting

Language: Английский

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