Archives of Toxicology, Journal Year: 2023, Volume and Issue: 97(6), P. 1439 - 1451
Published: May 2, 2023
Language: Английский
Cell Research, Journal Year: 2020, Volume and Issue: 31(2), P. 107 - 125
Published: Dec. 2, 2020
Abstract Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form non-apoptotic cell in 2012, there has been mounting interest process and function ferroptosis. Ferroptosis occur two major pathways, extrinsic or transporter-dependent pathway intrinsic enzyme-regulated pathway. is caused by a redox imbalance between production oxidants antioxidants, which driven abnormal expression activity multiple redox-active enzymes that produce detoxify free radicals lipid oxidation products. Accordingly, precisely regulated at levels, including epigenetic, transcriptional, posttranscriptional posttranslational layers. The transcription factor NFE2L2 plays central role upregulating anti-ferroptotic defense, whereas selective autophagy may promote ferroptotic death. Here, we review current knowledge on integrated molecular machinery describe how dysregulated involved cancer, neurodegeneration, tissue injury, inflammation, infection.
Language: Английский
Citations
2563
Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 18(5), P. 280 - 296
Published: Jan. 29, 2021
Language: Английский
Citations
2012
Cell Research, Journal Year: 2019, Volume and Issue: 29(5), P. 347 - 364
Published: April 4, 2019
Cells may die from accidental cell death (ACD) or regulated (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms have been identified are increasingly being implicated in various human pathologies. Here, we critically review the current state art regarding types RCD, including necroptosis, pyroptosis, ferroptosis, entotic death, netotic parthanatos, lysosome-dependent autophagy-dependent alkaliptosis oxeiptosis. The in-depth comprehension each these lethal subroutines their intercellular consequences uncover therapeutic targets for avoidance pathogenic loss.
Language: Английский
Citations
1992
Cancer Cell, Journal Year: 2019, Volume and Issue: 35(6), P. 830 - 849
Published: May 16, 2019
Language: Английский
Citations
1952
Autophagy, Journal Year: 2020, Volume and Issue: 17(9), P. 2054 - 2081
Published: Aug. 19, 2020
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which controlled integrated oxidation and antioxidant systems. The iron-containing enzyme lipoxygenase the main promoter ferroptosis producing hydroperoxides, its function relies on activation ACSL4-dependent biosynthesis. In contrast, selenium-containing GPX4 currently recognized as a central repressor ferroptosis, activity depends glutathione produced from cystine-glutamate antiporter SLC7A11. Many metabolic (especially involving iron, lipids, amino acids) degradation pathways (macroautophagy/autophagy ubiquitin-proteasome system) orchestrate complex ferroptotic response through direct or indirect regulation iron accumulation peroxidation. Although detailed mechanism membrane injury during remains mystery, ESCRT III-mediated plasma repair can make cells resistant to ferroptosis. Here, we review recent rapid progress in understanding molecular mechanisms focus epigenetic, transcriptional, posttranslational this process.Abbreviations: 2ME: beta-mercaptoethanol; α-KG: α-ketoglutarate; ccRCC: clear renal carcinoma; EMT: epithelial-mesenchymal transition; FAO: fatty acid beta-oxidation; GSH: glutathione; MEFs: mouse embryonic fibroblasts; MUFAs: monounsaturated acids; NO: nitric oxide; NOX: NADPH oxidase; PPP: pentose phosphate pathway; PUFA: polyunsaturated acid; RCD: death; RNS: reactive nitrogen species; ROS: oxygen RTAs: radical-trapping antioxidants; UPS: system; UTR: untranslated region.
Language: Английский
Citations
1336
Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)
Published: Oct. 8, 2019
Abstract Ferroptosis is a newly discovered form of regulated cell death that the nexus between metabolism, redox biology, and human health. Emerging evidence shows potential triggering ferroptosis for cancer therapy, particularly eradicating aggressive malignancies are resistant to traditional therapies. Recently, there has been great deal effort design develop anticancer drugs based on induction. Recent advances ferroptosis‐inducing agents at intersection chemistry, materials science, biology presented. The basis summarized first highlight feasibility characteristics therapy. A literature review inducers (including small molecules nanomaterials) then presented delineate their design, action mechanisms, applications. Finally, some considerations research spotlighted, followed by discussion challenges future development directions this burgeoning field.
Language: Английский
Citations
1271
Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)
Published: Feb. 3, 2021
Abstract Ferroptosis is an iron-dependent cell death, which different from apoptosis, necrosis, autophagy, and other forms of death. The process ferroptotic death defined by the accumulation lethal lipid species derived peroxidation lipids, can be prevented iron chelators (e.g., deferiprone, deferoxamine) small lipophilic antioxidants ferrostatin, liproxstatin). This review summarizes current knowledge about regulatory mechanism ferroptosis its association with several pathways, including iron, lipid, cysteine metabolism. We have further discussed contribution to pathogenesis diseases such as cancer, ischemia/reperfusion, various neurodegenerative Alzheimer’s disease Parkinson’s disease), evaluated therapeutic applications inhibitors in clinics.
Language: Английский
Citations
930
Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 66, P. 89 - 100
Published: March 14, 2019
Language: Английский
Citations
819
Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)
Published: Feb. 12, 2022
Abstract Ferroptosis is an intracellular iron-dependent form of cell death that distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest ferroptosis plays a pivotal role in tumor suppression, thus providing new opportunities for cancer therapy. The development resistance to therapy remains major challenge. A number preclinical clinical have focused on overcoming drug resistance. Intriguingly, has been correlated with resistance, inducing demonstrated reverse Herein, we provide detailed description the mechanisms therapeutic regulating reversing common therapies, such as chemotherapy, targeted immunotherapy. We discuss prospect challenge strategy expect our review could some references further studies.
Language: Английский
Citations
778
Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8
Published: Oct. 7, 2020
Ferroptosis is a form of regulated cell death that characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures the release damage-associated molecular patterns. Due to role iron in mediating production reactive oxygen species enzyme activity lipid peroxidation, ferroptosis strictly controlled regulators involved many aspects metabolism, such as uptake, storage, utilization, efflux. Translational transcriptional regulation homeostasis provide an integrated network determine sensitivity ferroptosis. Impaired implicated various iron-related pathological conditions or diseases, cancer, neurodegenerative ischemia-reperfusion injury. Understanding mechanisms underlying metabolism during may effective strategies for treatment ferroptosis-associated diseases. Indeed, chelators effectively prevent occurrence ferroptosis, which new approaches disorders. In this review, we summarize recent advances theoretical modeling highlight therapeutic implications
Language: Английский
Citations
674