From E-Waste to High-Value Materials: Sustainable Synthesis of Metal, Metal Oxide, and MOF Nanoparticles from Waste Printed Circuit Boards DOI Creative Commons
Tatiana Pineda-Vásquez, Leidy Rendón-Castrillón, Margarita Ramírez-Carmona

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 14(1), P. 69 - 69

Published: Dec. 26, 2023

The exponential growth of electronic waste (e-waste) has raised significant environmental concerns, with projections indicating a surge to 74.7 million metric tons e-waste generated by 2030. Waste printed circuit boards (WPCBs), constituting approximately 10% all e-waste, are particularly intriguing due their high content valuable metals and rare earth elements. However, the presence hazardous elements necessitates sustainable recycling strategies. This review explores innovative approaches metal nanoparticle synthesis from WPCBs. Efficient recovery WPCBs begins disassembly utilization advanced equipment for optimal separation. Various pretreatment techniques, including selective leaching magnetic separation, enhance efficiency. Green systems such as biohydrometallurgy offer eco-friendly alternatives, selectivity. Converting ions into nanoparticles involves concentration transformation methods like chemical precipitation, electrowinning, dialysis. These vital transforming recovered nanoparticles, promoting resource recycling. Sustainable green utilizing natural sources, microorganisms plants, discussed, focus on applications in producing well-defined nanoparticles. Nanoparticles derived find drug delivery, microelectronics, antimicrobial materials, remediation, diagnostics, catalysis, agriculture, etc. They contribute wastewater treatment, photocatalysis, protective coatings, biomedicine. important implications this lie its identification pivotal solution paving way practices supply materials diverse industrial applications.

Language: Английский

Modulating the gut microbiota: A novel perspective in colorectal cancer treatment DOI
Xue Bai,

Boyang Liu,

Daiming Fan

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217459 - 217459

Published: Jan. 1, 2025

Language: Английский

Citations

0
An ER Stress and Mitochondrial Apoptosis Co-inducer for Enhanced Cancer Immunotherapy DOI
Guangzhao Xu, Shuzhen Chen,

Hekai Yang

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217485 - 217485

Published: Jan. 1, 2025

Language: Английский

Citations

0
Copper(II)-Complexed Polyethylenimine-Entrapped Gold Nanoparticles Enable Targeted CT/MR Imaging and Chemodynamic Therapy of Tumors DOI Open Access
Lulu He, Na Liu, Rongqing Pan

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 423 - 423

Published: Feb. 6, 2025

Transition-metal ion copper(II) (Cu(II)) has drawn increasing attention as a small-molecular cancer theranostic agent. However, delivering sufficient dosage of Cu(II) to the tumor site and integrating multiple imaging modalities achieve precise effective theranostics remains critical challenge. Herein, an emerging Cu(II)-based nanocomposite been synthesized for targeted computed tomography (CT)/magnetic resonance (MR) dual-mode chemodynamic therapy (CDT). Briefly, 2-picolinic acid (PA-COOH), polyethylene glycol (PEG)-linked folic (FA), fluorescein isothiocyanate (FI) were sequentially conjugated with polyethylenimine (PEI.NH2) then in situ fabrication gold nanoparticles (Au NPs) occurred within PEI.NH2 internal cavity. After acetylation terminal amines complexation, nanocomposites FA-Au/Cu(II) PENPs mean diameter 2.87 nm generated. The showed favorable stability colloidal dispersion, sustainable release properties pH-dependent manner, Fenton-like catalytic activity specifically. With FA-mediated targeting pathway, can specifically accumulate cells high expression FA receptors. Meanwhile, complementary CT/MR vitro vivo be afforded by based on excellent X-ray attenuation Au NPs applicable r1 relaxivity (0.7378 mM−1s−1) Cu(II). Notably, Cu(II)-mediated CDT mechanism enables elicit generation toxic hydroxyl radicals (·OH), depletion glutathione (GSH), promotion lipid peroxidation (LPO), induction cell apoptosis vitro, further demonstrates remarkable anti-tumor efficacy xenograft model. illustrated capacity towards tumors, this paradigm inspires construction advanced nanoplatforms incorporating alternative transition metal ions.

Language: Английский

Citations

0
Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver DOI Creative Commons
Zehua Li, Tongwei Zhang,

Tongxiang Tao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Non-alcoholic fatty liver disease (NAFLD)-induced early-stage fibrosis is increasingly common. Non-invasive MRI detection offers an important diagnostic method to prevent from progressing cirrhosis or hepatocellular carcinoma. However, because confined the periportal areas, and changes in tissue structure stiffness are minimal, standard T1- T2-weighted imaging struggles capture these lesions. To address this challenge, a highly sensitive targeted T1-T2 dual-mode magnetic resonance (MRI) nanoprobe designed developed, specifically targeting characterized by activation of hepatic stellate cells (HSCs) overexpression platelet-derived growth factor receptor β (PDGFRβ). The exhibits excellent relaxivity (r2/r1 = 10.7) precise due PDGFRβ-specific peptides conjugated its protein nanocage. In vivo, animal models demonstrate effective accumulation probe fibrotic regions as NAFLD progressed, with fluorescence signal intensity accurately reflecting severity fibrosis. Using 7T system, T1 T2 images overlaid within 1 h, locating areas improving speed precision. shows biocompatibility enhances early NAFLD, offering significant clinical potential for diagnosis, prognosis, recurrence monitoring.

Language: Английский

Citations

0
Prodrug-designed nanocarrier co-delivering chemotherapeutic and vascular disrupting agents with exceptionally high drug loading capacity DOI

Huicong Zhou,

Zhaofan Yang,

Guan-Yu Jin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113628 - 113628

Published: March 1, 2025

Language: Английский

Citations

0
Nanoformulations: Reforming treatment for non-small cell lung cancer metastasis DOI

Shristy Jha,

Mangala Hegde,

Ruchira Banerjee

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116928 - 116928

Published: April 1, 2025

Language: Английский

Citations

0
Improved pharmacokinetic and lymphatic uptake of Rose Bengal after transfersome intradermal deposition using hollow microneedles DOI Creative Commons
Sara Demartis, Giovanna Rassu, Qonita Kurnia Anjani

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 363 - 375

Published: April 3, 2024

The lymphatic system is active in several processes that regulate human diseases, among which cancer progression stands out. Thus, various drug delivery systems have been investigated to promote targeting for therapy; mainly, nanosized particles the 10–150 nm range quickly achieve vessels after an interstitial administration. Herein, a strategy boost lymphotropic of Rose Bengal (RB), hydrosoluble chemotherapeutic, proposed, and it based on loading into Transfersomes (RBTF) their intradermal deposition vivo by microneedles. RBTF 96.27 ± 13.96 (PDI = 0.29 0.02) were prepared green reverse-phase evaporation technique, they showed RB encapsulation efficiency 98.54 0.09%. In vitro, remained physically stable under physiological conditions avoided release RB. vivo, intravenous injection prolonged half-life 50 min healthy rats compared injection; rat body was further increased reaching 24 h, regardless formulation used. Regarding targeting, administered intravenously provided accumulation lymph nodes 12.3 0.14 ng/mL 2 whereas no observed injection. Intradermally resulted highest amount detected h from (84.2 25.10 ng/mL), even visible naked eye pink colouration drug. case intradermally RB, node only at (13.3 1.41 ng/mL). conclusion, proved efficient carrier delivery, enhancing its pharmacokinetics promoting lymph-targeted delivery. represents promising nanomedicine product potentially facing medical need novel strategies therapy.

Language: Английский

Citations

3
Effective treatment of metastatic sentinel lymph nodes by dual-targeting melittin nanoparticles DOI Creative Commons
Yanfeng Dai, Xiang Yu,

Yuehong Leng

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 1, 2023

Sentinel lymph node (SLN) metastasis is an important promoter of distant in breast cancer. Therefore, the timely diagnosis and precise treatment are crucial for patient staging prognosis. However, simultaneous implementation imaging-guided SLN therapy challenging. Here, we report a melittin-loaded hyaluronic acid (HA)-conjugated high-density lipoprotein (HDL) mimic phospholipid scaffold nanoparticle (MLT-HA-HPPS), which dually-target to both cancer its efficiently inhibit LN model. The melittin peptide was successfully loaded onto HA-HPPS via electrostatic interactions, MLT-HA-HPPS possesses effective cytotoxicity 4T1 cells. Moreover, delivery from primary tumor into monitored by NIR fluorescence imaging, greatly benefits prognosis metastatic SLNs. After paracancerous administration, can growth with inhibition rate 81.3% 76.5% relative PBS-treated control group group, respectively. More importantly, effectively SLNs approximately 78.0%, 79.1%, 64.2% decrease weight than those PBS, HA-HPPS, melittin-treated mice, Taken together, may provide encouraging theranostic drug strategy progression prevent

Language: Английский

Citations

9
Efficient and controllable co-delivery of paclitaxel and curcumin from fucoidan-pluronic F127 nanogel for synergistic breast cancer treatment DOI
Ngoc The Nguyen, Van Toan Nguyen,

Thanh Tam Vu

et al.

Macromolecular Research, Journal Year: 2024, Volume and Issue: 32(5), P. 427 - 442

Published: Jan. 10, 2024

Language: Английский

Citations

2
Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy DOI

Bethsebie Lalduhsaki Sailo,

Suravi Chauhan,

Mangala Hegde

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 14, 2024

Abstract Chemoresistance is the adaptation of cancer cells against therapeutic agents. When exhibited by cells, chemoresistance helps them to avoid apoptosis, cause relapse, and metastasize, making it challenging for chemotherapeutic agents treat cancer. Various strategies like dosage modification drugs, nanoparticle‐based delivery chemotherapeutics, antibody‐drug conjugates, so on are being used target reverse chemoresistance, one among such combination therapy. It uses two or more multidrug resistance improve effects chemotherapy. Phytochemicals known exhibit chemosensitizing properties found be effective various cancers. Tocotrienols (T3) tocopherols (T) natural bioactive analogs vitamin E, which important medicinal value potential curative apart from serving as an antioxidant nutrient supplement. Notably, T3 exhibits a variety pharmacological activities anticancer, anti‐inflammatory, antiproliferative, on. The property tocotrienol modulating several signaling pathways molecular targets involved in cell survival, proliferation, invasion, migration, metastasis NF‐κB, STATs, Akt/mTOR, Bax/Bcl‐2, Wnt/β‐catenin, many more. sensitizes drugs including cisplatin, doxorubicin, paclitaxel increasing drug concentration cytotoxicity. Discussed herewith tocotrienols types when combined with biological molecules.

Language: Английский

Citations

2