Exploring the Pharmacological & Therapeutic Potential of Monoamine Oxidase Inhibitors in Lung Cancer Treatment: Unearthing Novel Pathways for Clinical Advancement DOI Open Access
Minesh Patel,

Dr G.S Chakraborthy

Published: Oct. 27, 2023

Lung cancer, globally recognized as the leading cause of cancer-related mortality, presents a pressing need for innovative treatment strategies. Increasing evidence points towards potential monoamine oxidase (MAO) inhibitors in modulating cancer progression, primarily due to their role regulating cellular metabolism and apoptotic pathways. This extraordinary study delves into multifaceted therapeutic implications MAO lung management, elucidating ability pave way clinical advancement via novel targets Capitalizing on recent advances molecular biology, this research explores mechanisms underlying anticancer actions inhibitors. By examining impact cell proliferation, migration, invasion, apoptosis lines, we provide insight intricate signaling pathways biochemical processes modulated by these compounds. The also investigates synergistic effects combination with established chemotherapeutic agents, enhance efficacy reduce cytotoxicity. Furthermore, delve tumor microenvironment, evaluating influence angiogenesis, immune regulation, epithelial-mesenchymal transition. comprehensive analysis enables identification targets, which hold promise development advanced therapeutics tailored specific subtypes. To substantiate our findings, review, thoroughly analyze existing literature using state-of-the-art bioinformatics tools." vivo orthotopic models, patient cohorts. robust multidisciplinary approach permits generation supporting integration management. Conclusion: ground-breaking establishes management unearthing advancement. outcomes open doors strategies inspire continued efforts combat global burden cancer.

Language: Английский

Tumor-Nerve Interactions in Cancer Regulation and Progression DOI

Jianyi Zhao,

Lilin Cheng, Jian Yang

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 612, P. 217483 - 217483

Published: Jan. 20, 2025

Language: Английский

Citations

1
Tracing the Evolution of Sex Hormones and Receptor‐Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease DOI Creative Commons
Dengxiong Li, Zhipeng Wang, Qingxin Yu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract The bladder and prostate originate from the urogenital sinus. However, cancer (BC) is usually classified as an immune “hot” tumor, whereas (PCa) deemed “cold” tumor according to microenvironment (TME) clinical outcomes. To investigate differences between BC PCa, studies are compared focusing on regulation mediated by sex hormones receptors identify key genes pathways responsible for differences. From a developmental perspective, it shown that PCa activate similar those in stage. During development, differential expression function of androgen receptor (AR) across cell types may contribute its dual role promoting inhibiting immunity different cells. Androgen deprivation therapy affects AR cells within TME, influencing infiltration antitumor function. Additionally, estrogenα estrogenβ exert contrasting effects BC, which hold potential modifying phenotypes. Future research should target involved development clarify regulatory similarities PCa.

Language: Английский

Citations

1
Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators DOI Creative Commons
Yifan Ma,

H.S. Chen,

Hui Li

et al.

Cancer Immunology Immunotherapy, Journal Year: 2024, Volume and Issue: 73(3)

Published: Feb. 13, 2024

Abstract Monoamine oxidase A (MAOA) is a membrane-bound mitochondrial enzyme present in almost all vertebrate tissues that catalyzes the degradation of biogenic and dietary-derived monoamines. MAOA known for regulating neurotransmitter metabolism has been implicated antitumor immune responses. In this review, we retrospect inhibits activities various types tumor-associated cells (such as CD8 + T macrophages) by their intracellular monoamines metabolites. Developing novel inhibitor drugs exploring multidrug combination strategies may enhance efficacy governance. Thus, act checkpoint or immunomodulator influencing effectiveness immunotherapy. conclusion, promising target merits further in-depth exploration preclinical clinical settings.

Language: Английский

Citations

7
Evaluation of a new scoring system for assessing nerve invasion in resected pancreatic cancer: a single-center retrospective analysis DOI
Rong Hua, Hong-Fei Yao,

Zi-Yu Song

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 603, P. 217213 - 217213

Published: Sept. 6, 2024

Language: Английский

Citations

7
Nervous system in colorectal cancer DOI
Chunjie Xu, Chunhui Jiang, Yuan Tian

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217431 - 217431

Published: Dec. 1, 2024

Language: Английский

Citations

5
Role of Semaphorins, neuropilins and plexins in cancer progression DOI Creative Commons
Patricia Fernández-Nogueira,

P Linzoain-Agos,

Mateo Cueto‐Remacha

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 606, P. 217308 - 217308

Published: Oct. 30, 2024

Language: Английский

Citations

4
GZ17-6.02 interacts with carboplatin and etoposide to kill neuroblastoma cells DOI

Michael R. Booth,

Laurence Booth,

Jane L. Roberts

et al.

Anti-Cancer Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

The biology of GZ17-6.02 alone and more so in combination with either the standard-of-care agents etoposide or carboplatin killed MYCN overexpressing neuroblastoma (NB) cells is unknown. methods involved this study are in-cell immunoblotting, trypan blue exclusion, plasmid siRNA transfection, assessment autophagy using a expressing LC3-GFP-RFP. (602) comprises, by mass, ratio curcumin (1.0), harmine (1.3), isovanillin (7.7). In tumors dosed 602, becomes (16), (6.1) (602NR). activated ATM, AMPK, ULK1, ATG13, PERK inactivated ERBB1, ERBB2, ERBB3, ERBB4, AKT, mTORC1, mTORC2, SRC, NFκB, YAP, eIF2α. 602 enhanced autophagosome formation autophagic flux that was amplified when it combined carboplatin. Compared 602NR caused significantly greater also chemotherapy which reduced ~40% knockdown ATM AMPKα abolished Beclin1 ATG5. Knockdown tumor cell death 602NR, whereas endoplasmic reticulum stress (eIF2α) macroautophagy (Beclin1, ATG5) were effective at maintaining survival. Combined receptor CD95 almost antitumor actions 602NR. kills NB interacts chemotherapeutics to cause further killing via signaling.

Language: Английский

Citations

0
The inhibition of monoamine oxidase by 2-methylbenzo[d]oxazole derivatives DOI Creative Commons

Maryké Shaw,

Jacobus P. Petzer, Theunis T. Cloete

et al.

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Language: Английский

Citations

0
Effect of Hydroxytyrosol Derivatives of Donepezil on the Activity of Enzymes Involved in Neurodegenerative Diseases and Oxidative Damage DOI Creative Commons
Antônio Alberto D'Errico, Rosarita Nasso, Rosario Rullo

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 548 - 548

Published: Jan. 22, 2024

Monoamine oxidase and xanthine inhibitors represent useful multi-target drugs for the prevention, attenuation, treatment of oxidative damage neurodegenerative disorders. Chimeric molecules, constituted by naturally derived compounds linked to drugs, lead be explored discovery new synthetic acting as enzyme inhibitors. We have previously reported that seven hydroxytyrosol-donepezil hybrid play a protective role in an vitro neuronal cell model Alzheimer’s disease. In this work, we analyzed effects exerted on activity monoamine A (MAO-A) B (MAO-B), well (XO), enzymes involved both disorders stress. The results pointed identification, among tested, selective between two classes enzymes. While 4-hydroxy-3-methoxyphenethyl 1-benzylpiperidine-4-carboxylate- (HT3) 4-hydroxyphenethyl donepezil derivatives (HT4) represented best MAO-A, with scarce effect MAO-B, they were almost ineffective XO. On other hand, 4,5-dihydroxy-2-nitrophenethyl 1-benzylpiperidine-4-carboxylate derivative (HT2), least efficient MAO inhibitor, acted like XO inhibitor. Therefore, differential enzymatic targets identified synthesized enhance possible applications these polyphenol-donepezil hybrids

Language: Английский

Citations

1
A study predicting long-term survival capacity in postoperative advanced gastric cancer patients based on MAOA and subcutaneous muscle fat characteristics DOI Creative Commons
Yubo Han,

Yaoyuan Chang,

Jiaqi Wang

et al.

World Journal of Surgical Oncology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 16, 2024

The prognosis of advanced gastric cancer (AGC) is relatively poor, and long-term survival depends on timely intervention. Currently, predicting rates remains a hot topic. application radiomics immunohistochemistry-related techniques in research increasingly widespread. However, their integration for AGC patients has not been fully explored.

Language: Английский

Citations

1