International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13722 - 13722
Published: Dec. 23, 2024
As
the
primary
glial
cells
in
peripheral
nervous
system
(PNS),
Schwann
(SCs)
have
been
proven
to
influence
behavior
of
cancer
profoundly
and
are
involved
progression
through
extensive
interactions
with
other
stromal
cells.
Indeed,
tumor
microenvironment
(TME)
is
a
critical
factor
that
can
significantly
limit
efficacy
immunotherapeutic
approaches.
The
TME
promotes
part
by
reshaping
an
immunosuppressive
state.
result
crosstalk
between
different
immune
cell
subsets,
including
macrophages,
natural
killer
(NK)
cells,
dendritic
(DCs),
lymphocytes,
myeloid-derived
suppressor
(MDSCs),
etc.
They
closely
related
anti-tumor
status
clinical
prognosis
patients.
Increasing
research
demonstrates
SCs
these
reshape
formation
via
secretion
various
cytokines,
chemokines,
effector
molecules,
eventually
facilitating
evasion
progression.
In
this
review,
we
summarize
SC
reprogramming
TME,
emerging
role
microenvironment,
underlying
mechanisms
involved.
We
also
discuss
possible
therapeutic
strategies
selectively
target
SCs,
providing
insights
perspectives
for
future
studies
involving
SC-targeted
treatment.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 31, 2025
Head
and
neck
cancer
(HNC)
is
an
aggressive
malignancy
with
significant
effects
on
the
innervation.
Not
only
it
at
top
of
spectrum
a
dismal
prognosis,
but
also
imposes
considerable
stress
patients
society
owing
to
frequent
neurological
symptoms.
With
progress
in
neuroscience,
interactions
between
HNC
nervous
system,
as
well
underlying
mechanisms,
have
become
increasingly
clear.
Compelling
evidence
suggests
communication
information
nerve
cells
devastation
system
tumor
growth.
However,
thorough
grasp
neuroscience
has
been
severely
constrained
by
intricacy
fragmented
research.
This
review
comprehensively
organizes
summarizes
latest
research
crosstalk
system.
It
aims
clarify
various
aspects
HNC,
including
physiology,
progression,
treatment
cancer.
Furthermore,
opportunities
challenges
are
discussed,
which
offers
fresh
perspectives
diagnosis
management.
Oral Oncology Reports,
Journal Year:
2024,
Volume and Issue:
10, P. 100397 - 100397
Published: April 12, 2024
•
Genomics
and
transcriptomics
offer
insights
into
oral
oncogenesis,
revealing
genetic
alterations
to
gene
expression
patterns.
Co-analysis
enables
personalized
diagnostic
therapeutic
approaches
by
linking
mutations
signatures.
Integrative
projects
advance
precision
medicine
for
cancer
treatment.
Journal of Interferon & Cytokine Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Pancreatic
cancer
(PC)
is
a
with
poor
prognosis,
and
nerve
growth
factor
(NGF)
involved
in
the
pathogenesis
of
PC
within
unknown
exact
role.
Herein,
SW1990
cells
PC12
were
co-cultured
using
transwell
co-culture
system
subsequently
revealed
that
NGF
was
overexpressed
promoted
cell
proliferation.
Knockdown
expression
lentiviral
shRNA
effectively
inhibited
reduced
its
stimulatory
effect
on
Additionally,
increased
IL-6,
dopamine,
c-FOS,
as
well
decreased
level
lactate
dehydrogenase,
cells,
whereas
inhibition
significantly
levels
dopamine
indicating
critical
role
IL-6/STAT3
signaling
progression.
Finally,
proliferation,
migration,
invasion
assessed
counting
kit-8,
scratch,
Transwell
assays,
which
showed
activated
neurons
invasion,
secretion
through
pathway.
The
results
secreted
by
played
pivotal
progression
via
regulating
neural
cells-secreted
providing
new
theoretical
insights
for
treatment
PC.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13722 - 13722
Published: Dec. 23, 2024
As
the
primary
glial
cells
in
peripheral
nervous
system
(PNS),
Schwann
(SCs)
have
been
proven
to
influence
behavior
of
cancer
profoundly
and
are
involved
progression
through
extensive
interactions
with
other
stromal
cells.
Indeed,
tumor
microenvironment
(TME)
is
a
critical
factor
that
can
significantly
limit
efficacy
immunotherapeutic
approaches.
The
TME
promotes
part
by
reshaping
an
immunosuppressive
state.
result
crosstalk
between
different
immune
cell
subsets,
including
macrophages,
natural
killer
(NK)
cells,
dendritic
(DCs),
lymphocytes,
myeloid-derived
suppressor
(MDSCs),
etc.
They
closely
related
anti-tumor
status
clinical
prognosis
patients.
Increasing
research
demonstrates
SCs
these
reshape
formation
via
secretion
various
cytokines,
chemokines,
effector
molecules,
eventually
facilitating
evasion
progression.
In
this
review,
we
summarize
SC
reprogramming
TME,
emerging
role
microenvironment,
underlying
mechanisms
involved.
We
also
discuss
possible
therapeutic
strategies
selectively
target
SCs,
providing
insights
perspectives
for
future
studies
involving
SC-targeted
treatment.
