Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Language: Английский

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Tumor-Nerve Interactions in Cancer Regulation and Progression

Cancer Letters, Journal Year: 2025, Volume and Issue: 612, P. 217483 - 217483

Published: Jan. 20, 2025

Language: Английский

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Defeating lethal cancer: Interrupting the ecologic and evolutionary basis of death from malignancy

CA A Cancer Journal for Clinicians, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Despite the advances in cancer prevention, early detection, and treatments, all of which have led to improved survival, globally, there is an increased incidence cancer-related deaths. Although each patient tumor wholly unique, tipping point incurable disease common across patients: dual capacity for cancers metastasize resist systemic treatment. The discovery genetic mutations epigenetic variation that emerges during progression highlights evolutionary ecology principles can be used understand how evolves a lethal phenotype. By applying such eco-evolutionary framework, authors reinterpret our understanding metastatic process as one ecologic invasion define paths evolving therapy resistance. With this understanding, draw from successful strategies optimized strategic interventions with goal altering trajectory cancer. Ultimately, studying, treating using provides opportunity improve lives patients

Language: Английский

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Role of human microbiota in facilitating the metastatic journey of cancer cells

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

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Decoding STING’s roles in cancer: immunity, pain, dormancy, and autophagy

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

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Gene regulatory network transitions reveal the central transcription factors in lung adenocarcinoma progression

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract Transcription factors play a central role in cancer growth, progression, and metastasis, contribute to intratumor phenotypic plasticity which enable drug tolerance relapse. Changes the regulatory activities of transcription may not always be detected by investigating mutational signatures or differential expression factor, as done traditional analysis. In addition, past studies have focused on tumors whole thus, fully captured heterogeneity gene regulation among different cell types within tumor microenvironment. this work, through an analysis transitions network architecture dynamics, we identify associated with lung adenocarcinoma progression. The NR2F1 , neurodevelopment dormancy, emerge key factor progression adenocarcinoma. We further that are only active samples uncover how changes dynamics influence heterogeneity. Taken together, our work elucidates during identifies process, reveals complex cooccurring

Language: Английский

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SNAI2 enhances HPV‑negative cervical cancer cell dormancy by modulating u‑PAR expression and the activity of the ERK/p38 signaling pathway in vitro

Oncology Reports, Journal Year: 2024, Volume and Issue: 52(2)

Published: June 27, 2024

Language: Английский

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Dormancy and awakening of cancer cells: the extracellular vesicle-mediated cross-talk between Dr. Jekill and Mr. Hyde

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 5, 2024

Cancer cell dormancy is a reversible process whereby cancer cells enter quiescent state characterized by cycle arrest, inhibition of migration and invasion, increased chemoresistance. Because its reversibility resistance to treatment, key study, monitor, interfere with, in order prevent tumor recurrence metastasis improve the prognosis patients. However, achieve this goal, further studies are needed elucidate mechanisms underlying complex dynamic dual process. Here, we review contribution extracellular vesicles (EVs) regulation dormancy/awakening, focusing on cross-talk between non-tumor both primary (pre-)metastatic niche. Although EVs recognized as players progression metastasis, well diagnostics therapeutics, their role specifically induction/escape still largely elusive. We report most recent promising results topic, EV-associated nucleic acids involved. highlight how EV could greatly contribute identification signaling pathways dormancy/early awakening signature for development successful diagnostic/prognostic therapeutic approaches.

Language: Английский

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Immune microenvironment of cancer bone metastasis

Bone, Journal Year: 2024, Volume and Issue: 191, P. 117328 - 117328

Published: Nov. 14, 2024

Language: Английский

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