Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases DOI Creative Commons

Shreya Kapoor,

Muskan Gupta,

Leena Sapra

et al.

Bone Reports, Journal Year: 2024, Volume and Issue: 23, P. 101809 - 101809

Published: Oct. 11, 2024

Emerging insights in osteoimmunology have enabled researchers to explore depth the role of immune modulation regulating bone health. Bone is one common sites metastasis notably case breast cancer, prostate cancer and several other types. High calcium ion concentration presence factors within mineralized matrix including TGF-β, BMP etc., aid tumor growth proliferation. Accumulating evidence has substantiated gut-microbiota (GM) tumorigenesis, further providing a strong impetus for growing "immune-cancer-gut microbiota" relationship. Recent advancements research highlight importance intra-tumor microbiota conjunction with GM metastasis. Intratumoral owing their ability cause genetic instability, mutations, epigenetic modifications microenvironment, been recognized affect cell physiology. The host system crosstalk shapes innate adaptive arms system, which key player progression. In this review, we aim decipher microorganisms mediating by shedding light on immuno-onco-microbiome (IOM) axis. We discussed feasible therapeutic interventions based microbiome-immune axis includes prebiotics, probiotics, postbiotics. Here, leverage conceptual framework published articles microbiota-based therapies target metastases. Understanding complicated nexus will provide into fundamental governing metastases subsequently help managing malignancy better efficacy.

Language: Английский

Dual roles of myeloid-derived suppressor cells in various diseases: a review DOI
Mahesh R. Nepal,

S. P. Shah,

Kyu‐Tae Kang

et al.

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(7), P. 597 - 616

Published: July 1, 2024

Language: Английский

Citations

5
The mechanism of cytokine regulation of cancer occurrence and development in the tumor microenvironment and its application in cancer treatment: a narrative review DOI Open Access
Rongjun Qu, Yanhong Zhao,

Y. Zhang

et al.

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5649 - 5663

Published: Oct. 1, 2024

The occurrence and development of tumors in human tissues widely depend on their surrounding environment, known as the tumor microenvironment (TME), which comprises various cells, molecules, blood vessels. Through modifications, organization, integration, these elements serve potential therapeutic targets anti-cancer therapy, supporting promoting proliferation, invasion, metabolism cells. Cytokines within TME are responsible for immune cell activation, differentiation, thereby influencing tumor's behavior. This article reviews use cytokines immunotherapy combs network signals that mediate malignancies.

Language: Английский

Citations

3
Development of CD73 Inhibitors in Tumor Immunotherapy and Opportunities in Imaging and Combination Therapy DOI Creative Commons
Chunyang Bi, Jimmy S. Patel, Steven H. Liang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

CD73 is a member of the membrane-bound enucleotidase family, which catalyzes extracellular hydrolysis adenosine monophosphate (AMP) to produce anti-inflammatory and immunosuppressive adenosine. As novel checkpoint protein, overexpressed in immune system various tumors, where abundantly enriched. A large number monoclonal antibodies (mAbs), nucleotides, non-nucleotides as potent inhibitors are being discovered, providing opportunities for tumor immunotherapy. Currently, 18 clinical trials, showing promising results combination therapy solid tumors. The development CD73-specific companion positron emission tomography imaging ligands holds potential facilitating diagnosis, patient selection, treatment efficacy evaluation throughout entire process CD73-targeted therapeutic development.

Language: Английский

Citations

0
Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases DOI Creative Commons

Shreya Kapoor,

Muskan Gupta,

Leena Sapra

et al.

Bone Reports, Journal Year: 2024, Volume and Issue: 23, P. 101809 - 101809

Published: Oct. 11, 2024

Emerging insights in osteoimmunology have enabled researchers to explore depth the role of immune modulation regulating bone health. Bone is one common sites metastasis notably case breast cancer, prostate cancer and several other types. High calcium ion concentration presence factors within mineralized matrix including TGF-β, BMP etc., aid tumor growth proliferation. Accumulating evidence has substantiated gut-microbiota (GM) tumorigenesis, further providing a strong impetus for growing "immune-cancer-gut microbiota" relationship. Recent advancements research highlight importance intra-tumor microbiota conjunction with GM metastasis. Intratumoral owing their ability cause genetic instability, mutations, epigenetic modifications microenvironment, been recognized affect cell physiology. The host system crosstalk shapes innate adaptive arms system, which key player progression. In this review, we aim decipher microorganisms mediating by shedding light on immuno-onco-microbiome (IOM) axis. We discussed feasible therapeutic interventions based microbiome-immune axis includes prebiotics, probiotics, postbiotics. Here, leverage conceptual framework published articles microbiota-based therapies target metastases. Understanding complicated nexus will provide into fundamental governing metastases subsequently help managing malignancy better efficacy.

Language: Английский

Citations

0