Theranostics,
Journal Year:
2025,
Volume and Issue:
15(5), P. 1787 - 1821
Published: Jan. 2, 2025
Lactate
is
an
indispensable
substance
in
various
cellular
physiological
functions
and
plays
regulatory
roles
different
aspects
of
energy
metabolism
signal
transduction.
Lactylation
(Kla),
a
key
pathway
through
which
lactate
exerts
its
functions,
has
been
identified
as
novel
posttranslational
modification
(PTM).
Research
indicates
that
Kla
essential
balancing
mechanism
variety
organisms
involved
many
biological
processes
pathways.
closely
related
to
disease
development
represents
potential
important
new
drug
target.
In
line
with
existing
reports,
we
searched
for
newly
discovered
sites
on
histone
nonhistone
proteins;
reviewed
the
mechanisms
(particularly
focusing
enzymes
directly
reversible
regulation
Kla,
including
"writers"
(modifying
enzymes),
"readers"
(modification-binding
"erasers"
(demodifying
enzymes);
summarized
crosstalk
between
PTMs
help
researchers
better
understand
widespread
distribution
diverse
functions.
Furthermore,
considering
"double-edged
sword"
role
both
pathological
contexts,
this
review
highlights
"beneficial"
states
(energy
metabolism,
inflammatory
responses,
cell
fate
determination,
development,
etc.)
"detrimental"
pathogenic
or
inducive
effects
processes,
particularly
malignant
tumors
complex
nontumor
diseases.
We
also
clarify
molecular
health
disease,
discuss
feasibility
therapeutic
Finally,
describe
detection
technologies
their
applications
diagnosis
clinical
settings,
aiming
provide
insights
treatment
diseases
accelerate
translation
from
laboratory
research
practice.
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: July 15, 2024
Lactylation,
an
emerging
post-translational
modification,
plays
a
pivotal
role
in
the
initiation
and
progression
of
digestive
system
tumors.
This
study
presents
comprehensive
review
lactylation
tumors,
underscoring
its
critical
involvement
tumor
development
progression.
By
focusing
on
metabolic
reprogramming,
modulation
microenvironment,
molecular
mechanisms
regulating
progression,
potential
targeting
as
therapeutic
strategy
is
highlighted.
The
research
reveals
that
participates
gene
expression
regulation
cell
signaling
by
affecting
states
histones
non-histone
proteins,
thereby
influencing
pathways
immune
evasion
cells.
Furthermore,
this
assesses
feasibility
target,
providing
insights
for
clinical
treatment
gastrointestinal
cancers.
Future
should
concentrate
elucidating
lactylation,
developing
efficient
inhibitors,
validating
their
efficacy
trials,
which
could
transform
current
cancer
immunotherapy
approaches.
In
summary,
emphasizes
crucial
tumorigenesis
through
detailed
analysis
significance.
Molecular Cell,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
The
recently
discovered
lysine
lactylation
represents
a
critical
post-translational
modification
with
widespread
implications
in
epigenetics
and
cancer
biology.
Initially
identified
on
histones,
has
been
also
described
non-histone
proteins,
playing
pivotal
role
transcriptional
activation,
protein
function,
cellular
processes.
Two
major
sources
of
the
lactyl
moiety
have
currently
distinguished:
L-lactyl-CoA
(precursor
L-lactyl
moiety)
S-D-lactylglutathione
D-lactyl
moiety),
which
enable
enzymatic
non-enzymatic
mechanisms
lactylation,
respectively.
Although
specific
writers,
erasers,
readers
this
are
still
unclear,
acetyltransferases
deacetylases
proposed
as
crucial
mediators
lactylation.
Remarkably,
exerts
significant
influence
cancer-related
pathways,
thereby
shaping
behavior
during
malignant
transformation
metastatic
cascade.
Hence,
recent
insights
into
underscore
its
growing
potential
tumor
biology,
targeting
is
emerging
opportunity
for
treatment.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: March 14, 2025
Lactylation,
a
novel
post-translational
modification,
has
emerged
as
critical
regulatory
mechanism
in
various
biological
processes,
including
tumor
progression.
However,
its
role
and
associated
gene
signatures
lung
adenocarcinoma
(LUAD)
remain
unclear.
RNA
sequencing
data
of
LUAD
patients
were
obtained
from
The
Cancer
Genome
Atlas
(TCGA)
Gene
Expression
Omnibus
(GEO)
databases.
Unsupervised
clustering
was
used
to
identify
lactylation-related
genes.
A
risk
prognostic
model
constructed
using
least
absolute
shrinkage
selection
operator
regression
analysis
subsequently
validated.
nomogram
then
employed
optimize
the
clinical
applicability
score.
Additionally,
algorithms
explore
relationship
between
score
immune
infiltration
levels,
with
genes
analyzed
based
on
single-cell
sequencing.
effects
RCCD1
knockdown
cell
proliferation
migration
evaluated
through
CCK8
transwell
assays.
Higher
scores
poorer
overall
survival
prognosis.
Immune
revealed
that
may
play
regulating
microenvironment.
these
found
be
chemotherapy
drug
sensitivity.
series
experiments
further
demonstrated
promotes
vitro.
This
study
highlights
their
association
infiltration,
providing
insights
into
potential
therapeutic
targets
biomarkers
for
application.
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Cellular
senescence
is
the
basic
unit
of
organismal
aging,
a
complicated
biological
process
involving
several
cell
types
and
tissues.
It
also
an
important
mechanism
by
which
body
responds
to
damage
potential
carcinogenesis.
However,
excessive
or
abnormal
cellular
can
lead
tissue
functional
degradation
occurrence
diseases.
In
recent
years,
role
epigenetic
modifications
in
has
received
extensive
attention.
Lactylation,
novel
post-translational
modification
derived
from
lactate,
recently
gained
significant
attention
as
key
factor
metabolism
regulation,
gradually
demonstrating
its
importance
regulation
senescence.
This
review
emphasizes
bidirectional
causal
relationship
between
lactylation
senescence,
highlighting
therapeutic
target
for
aging-related
Cell Proliferation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
ABSTRACT
Lactate
is
not
only
a
byproduct
of
glycolysis,
but
also
considered
an
energy
source,
gluconeogenic
precursor,
signalling
molecule
and
protein
modifier
during
the
process
cellular
metabolism.
The
discovery
lactylation
reveals
multifaceted
functions
lactate
in
metabolism
opens
new
avenues
for
lactate‐related
research.
Both
have
been
implicated
regulating
numerous
biological
processes,
including
tumour
progression,
ischemic–hypoxic
injury,
neurodevelopment
immune‐related
inflammation.
kidney
plays
crucial
role
metabolism,
influencing
levels
while
being
regulated
by
lactate.
Previous
studies
demonstrated
importance
pathogenesis
acute
injury
(AKI)
chronic
disease
(CKD).
This
review
explores
these
diseases,
comparing
function
metabolic
mechanisms
normal
diseased
kidneys
from
perspective
lactylation.
key
regulatory
roles
different
organs,
multiple
systems,
various
pathological
states
underlying
AKI‐to‐CKD
progression
are
summarised.
Moreover,
potential
therapeutic
targets
future
research
directions
across
diseases
identified.
