Triterpenes from Ganoderma lucidum inhibit hepatocellular carcinoma by regulating enhancer-associated lncRNA in vivo DOI

Ruolin Zhao,

Caiyun Zhang, Chenchen Tang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118706 - 118706

Published: Aug. 24, 2024

Language: Английский

A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma DOI Creative Commons

Xingyang Zhao,

Feichao Xuan,

Zirong Li

et al.

npj Vaccines, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 3, 2025

Language: Английский

Citations

0
BRD4 interacting genes as prognostic biomarkers in hepatocellular carcinoma for optimized treatment strategies DOI Creative Commons

Huapeng Zhang,

Jie Yu, Feng Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 15, 2025

BRD4, a member of the BET family proteins, is extensively studied in cancer and known for its complex network within tumor cells, interacting with various transcription factors epigenetic regulatory proteins. However, impact BRD4 associated genes on hepatocellular carcinoma (HCC) remains unclear. HCC one leading causes cancer-related deaths globally, often diagnosed at an advanced stage, limiting treatment options. In this study, we curated BRD4-interacting and, through analysis TCGA-LIHC dataset, developed four-gene prognostic model comprising EZH2, KIF20A, G6PD, KIF2C. This demonstrated strong predictive power both training validation cohorts, high gene expression levels significantly correlating poor prognosis. Furthermore, our revealed significant immunological differences between risk groups identified increased drug sensitivity high-risk patients to certain medications, while decreased others. Experimental further indicated that combination inhibitor ZBC260 EZH2 CPI-169 synergistically enhanced apoptosis HCC. Collectively, study provides scientific rationale early diagnosis personalized therapy, offering new insights into resistance treatment.

Language: Английский

Citations

0
Metabolic-associated fatty liver disease (MAFLD) promotes the progression of hepatocellular carcinoma by enhancing KIF20A expression DOI

Xinsong Hu,

Yifei Chen, Hao Ying

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114589 - 114589

Published: April 2, 2025

Language: Английский

Citations

0
CEA-Induced PI3K/AKT Pathway Activation through the Binding of CEA to KRT1 Contributes to Oxaliplatin Resistance in Gastric Cancer DOI
Yifan Chen,

Yulong Mi,

Song Tan

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 78, P. 101179 - 101179

Published: Dec. 3, 2024

Language: Английский

Citations

2
Triterpenes from Ganoderma lucidum inhibit hepatocellular carcinoma by regulating enhancer-associated lncRNA in vivo DOI

Ruolin Zhao,

Caiyun Zhang, Chenchen Tang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118706 - 118706

Published: Aug. 24, 2024

Language: Английский

Citations

1