The role of epigenetic regulation in pancreatic ductal adenocarcinoma progression and drug response: an integrative genomic and pharmacological prognostic prediction model DOI Creative Commons
Kang Fu, Junzhe Su, Yuan Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 21, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with poor prognosis. Epigenetic dysregulation plays crucial role in PDAC progression, but its comprehensive landscape and clinical implications remain unclear.

Language: Английский

Leveraging Epigenetic Alterations in Pancreatic Ductal Adenocarcinoma for Clinical Applications DOI Creative Commons
Jörg Tost,

Secil Ak-Aksoy,

Daniele Campa

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Melatonin Modulates ZAP70 and CD40 Transcripts via Histone Modifications in Canine Ileum Epithelial Cells DOI Creative Commons
Jian Hong,

Saber Y. Adam,

Shiqi Wang

et al.

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(2), P. 87 - 87

Published: Jan. 23, 2025

Melatonin (MLT), produced by the pineal gland and other tissues, is known for its anti-inflammatory effects, particularly in regulating inflammatory markers cytokines intestinal cells. Our study aimed to investigate how MLT influences expression of genes through histone modification canine ileum epithelial cells (cIECs). In our experiment, cIECs were cultured divided into a control group (CON) an MLT-treatment group. did not significantly affect cell growth or death compared CON. However, treatment led upregulation CD40, ZAP70, IL7R downregulation LCK, RPL37, TNFRSF13B, CD4, CD40LG, BLNK, CIITA at mRNA level. Moreover, altered NF-kappa B signaling pathway upregulating genes, such as TICAM1, VCAMI, GADD45B, IRAK1, TRADD, RELA, RIPK1, RELB, downregulating PRKCB, LY96, ILIB, TNFRSF11A. Using ChIP-qPCR, we discovered that enhanced acetylation marks H3K9ac, H3K18ac, H3K27ac, methylation H3K4me1 H3K4me3 ZAP70 CD40 gene loci (p < 0.05). Additionally, enrichment RNA polymerase II phosphorylated Ser5 pol-II these was increased MLT-treated 0.05), indicating heightened transcriptional activity. conclusion, findings suggest mitigates inflammation modulating transcription modifications, offering potential therapeutic insights bowel diseases.

Language: Английский

Citations

0
Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer DOI
Shu Tsukihara, Yoshimitsu Akiyama,

Shu Shimada

et al.

Oncogene, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Language: Английский

Citations

3
Potential Predictor of Epigenetic Age Acceleration in Men: 2D:4D Finger Pattern DOI
Paulina Pruszkowska‐Przybylska, Rezvan Noroozi, Joanna Rudnicka

et al.

American Journal of Human Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Second to fourth digit ratio is widely known indicator of prenatal sex hormones proportion. Higher androgenization results in longer finger and lower 2D:4D index. The aim this study was determine whether the associated with DNA methylation (DNAm) age dependently on sex.

Language: Английский

Citations

0
The role of epigenetic regulation in pancreatic ductal adenocarcinoma progression and drug response: an integrative genomic and pharmacological prognostic prediction model DOI Creative Commons
Kang Fu, Junzhe Su, Yuan Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 21, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with poor prognosis. Epigenetic dysregulation plays crucial role in PDAC progression, but its comprehensive landscape and clinical implications remain unclear.

Language: Английский

Citations

0