SAA1 released by tumor cells facilitates the aggressiveness of breast cancer by inducing reprogramming of molecular phenotypes in immune cells DOI Creative Commons

Jinkun Xia

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Most breast cancer patients are diagnosed at an advanced stage and have a poor prognosis. Recurrence of tumor metastasis major obstacles to clinical treatment. It is imperative explore new diagnostic prognostic markers improve the early diagnosis outcomes cancer. Recently, metastatic cancers transcriptional signature reveals Serum amyloid A1 (SAA1), acute-phase apolipoprotein reactant, associated with in expression clinicopathological features. However, its regulatory function remains elusive, contribution uncertain. In this research, we downloaded mRNA-sequencing data from Gene Expression Omnibus (GEO) database (GSE102818, GSE28785, GSE134591) comprehensively investigate relationship between SAA1 impact on implications, further unveiled connection SAA1-mediated immunoregulation We found that implicated cell migration regulation immune cells by modulating cytokine-cytokine receptor interaction. Meanwhile, released was demonstrated contribute inducing adipocytes reprogramming. Several current viewpoints propose reprogramming molecular phenotype driver invasion microenvironment. Based previous studies our findings, hypothesized cellular may also apply microenvironment, interaction through release relevant aggressiveness cancer, which help patient decision-making for immunotherapy.

Language: Английский

Osteopontin promotes tumor microenvironment remodeling and therapy resistance DOI
Chao Liu,

Shunjin Xia,

Wei Wang

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217618 - 217618

Published: March 1, 2025

Language: Английский

Citations

0
Prognostic Value of Centrosome Replication-Related Genes in Prostate Cancer Based on Transcriptomic and Mendelian Randomization DOI Creative Commons

Qizhong Lu,

Yufan Wu,

Qiwei Yu

et al.

American Journal of Men s Health, Journal Year: 2025, Volume and Issue: 19(2)

Published: March 1, 2025

Prostate cancer (PCa) is a significant global health concern, with its incidence and mortality rates projected to rise due population aging. In this study, we utilized PCa transcriptome data from public databases applied bioinformatics methods identify three prognostic genes ( CDC20 , RAD51 TTK ) related centrosome duplication in PCa. involved cell cycle regulation, deoxyribonucleic acid double-strand break repair, spindle assembly checkpoint function proliferation. We constructed risk model nomogram model, both demonstrating moderate good predictive performance area under the curve values ranging 0.611 0.765 at different time points. Gene set enrichment analysis revealed that these were enriched 64 pathways, including pathway, which dysregulated cancer. Furthermore, analyzed immune microenvironment identified 13 differential cells checkpoints between high- low-risk groups, providing insights into potential immunotherapy targets for conclusion, study contributes deeper understanding of pathogenesis lays important theoretical experimental foundations developing new diagnostic markers treatment strategies. Future research requires more clinical samples continued monitoring mechanism

Language: Английский

Citations

0
Ultrasound-guided percutaneous radiofrequency ablation combined with anti-PD-1 for the treatment of prostate cancer: an experimental study DOI Creative Commons
Si Chen, Ruiqing Liu, Shaobo Duan

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 24, 2025

Background This study seeks to investigate the potential synergistic effects of combining ultrasound-guided percutaneous radiofrequency ablation with anti-PD-1 therapy on prostate cancer, utilizing animal models. Methods A mouse model cancer was established by subcutaneous injection 1 × 10 6 Myc-Cap cells right side FVB mice. When volume tumors reached about 400mm 3 , mice were randomly divided into four groups and received corresponding intervention treatments. Among them, Group blank control group, 2 simple treatment 4 is group that combined under ultrasound guidance. The growth observed in after each tumor tissues collected, immune status analyzed through flow cytometry, immunohistochemistry, immunofluorescence, other methods. Results Compared groups, significantly reduced weight tumors, demonstrating more effective suppression. At same time, combination can promote aggregation T-cells within increase proportion cytotoxic T-cells, M1 macrophages iNOS expression, decrease M2 Arg expression local area tumors. Conclusion Local improve therapeutic effect PD-1 monoclonal antibody. Our preliminary results suggest ablation, treatment, produces effects. These may be driven changes cell populations tumor’s immunosuppressive microenvironment.

Language: Английский

Citations

0
Innovations and Emerging Trends in Prostate Cancer Management: A Literature Review DOI Open Access

Nazeer Ibraheem,

Momen Abdelglil,

Andrew Wanees

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Prostate cancer (PC) is considered the second most diagnosed in men worldwide. It remains a leading cause of cancer-related death. Recently, many modalities have been discovered and used diagnosis management PC, with incorporation treatment options such as hormonal therapy, chemotherapy, targeted therapies, immunotherapy, precision medicine. Robotics artificial intelligence (AI) further modified PCs, improving accuracy disease progression. This comprehensive review offers an in-depth exploration historical treatments, evaluation current therapeutic techniques, discussion use robotic surgery AI, examination ongoing clinical trials emerging procedures. Additionally, this also covers challenges. By inspecting these aspects, may provide valuable information regarding future research practice directions PC treatment, contributing to thorough understanding complex context management.

Language: Английский

Citations

0
SAA1 released by tumor cells facilitates the aggressiveness of breast cancer by inducing reprogramming of molecular phenotypes in immune cells DOI Creative Commons

Jinkun Xia

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Most breast cancer patients are diagnosed at an advanced stage and have a poor prognosis. Recurrence of tumor metastasis major obstacles to clinical treatment. It is imperative explore new diagnostic prognostic markers improve the early diagnosis outcomes cancer. Recently, metastatic cancers transcriptional signature reveals Serum amyloid A1 (SAA1), acute-phase apolipoprotein reactant, associated with in expression clinicopathological features. However, its regulatory function remains elusive, contribution uncertain. In this research, we downloaded mRNA-sequencing data from Gene Expression Omnibus (GEO) database (GSE102818, GSE28785, GSE134591) comprehensively investigate relationship between SAA1 impact on implications, further unveiled connection SAA1-mediated immunoregulation We found that implicated cell migration regulation immune cells by modulating cytokine-cytokine receptor interaction. Meanwhile, released was demonstrated contribute inducing adipocytes reprogramming. Several current viewpoints propose reprogramming molecular phenotype driver invasion microenvironment. Based previous studies our findings, hypothesized cellular may also apply microenvironment, interaction through release relevant aggressiveness cancer, which help patient decision-making for immunotherapy.

Language: Английский

Citations

0