Metronomic Chemotherapy and Drug Repurposing: Two Sides of an Oncology Coin To Reduce Host and Financial Toxicity

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217437 - 217437

Published: Jan. 1, 2025

Language: Английский

---

Vaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1170 - 1170

Published: Feb. 11, 2025

Viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV) play a critical role in the onset of oropharyngeal (OPC) nasopharyngeal cancer (NPC), respectively. Despite advancements targeted therapies immunotherapies, recurrent/metastatic setting, these tumors remain incurable diseases with poor prognosis. The development therapeutic tumor vaccines, utilizing either neoantigens or oncoviral antigens, represents promising addition to immunotherapy arsenal. Research on vaccine-based for OPC NPC focuses targeting viral particularly HPV E6/E7 EBV EBNA1/LMP2. potential vaccine platforms, including peptide-based, DNA, RNA, vector-based induce durable immune responses against antigens is reported. early-phase clinical trials evaluating HPV-related EBV-related revealed safety preliminary signs efficacy; however, further are crucial validation. This review provides an overview current landscape strategies NPC, discussing their biological mechanisms processes involved anti-HPV anti-EBV treatments, particular focus factors that influence therapies.

Language: Английский

---

Unveiling the nexus: The tumor microenvironment as a strategic frontier in viral cancers

Cytokine, Journal Year: 2024, Volume and Issue: 185, P. 156827 - 156827

Published: Dec. 7, 2024

Viral infections are a significant factor in the etiology of various cancers, with tumor microenvironment (TME) playing crucial role disease progression. This review delves into complex interactions between viruses and TME, highlighting how these shape course viral cancers. We explore distinct roles immune cells, including T-cells, B-cells, macrophages, dendritic within TME their influence on cancer The also examines oncoproteins manipulate to promote evasion survival. Unraveling mechanisms highlights emerging paradigm targeting as novel approach treatment. Our analysis provides insights dynamic interplay offering roadmap for innovative treatments that leverage unique characteristics

Language: Английский

---

Amygdalin in antineoplastic medicine and the relevance of nanotechnology

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117772 - 117772

Published: Dec. 18, 2024

Language: Английский

---