Effects of circulating RNAs on tumor metabolism in lung cancer (Review) DOI Open Access

Pengfei Zhao,

Zhengfeng Zhu, Xi Zheng

et al.

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 11

Published: Feb. 27, 2025

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis abnormal lipid amino acid to obtain energy nutrients for growth, proliferation drug resistance. Circular RNAs (circRNAs), a class non-coding RNAs, serve important biological roles in growth tumors. Functionally, circRNAs act as molecular sponges that absorb microRNAs (miRNAs) RNA-binding proteins protein scaffolds regulate gene transcription translation through maintenance mRNA stability. In addition, are regulators tumor promote mediating proliferation, metastasis induction chemoresistance. Results previous studies reveal may key role regulating metabolic processes miRNA sponging alternative mechanisms. demonstrate potential therapeutic targets cancer. The present study aimed review effects cancer provide novel insights into clinical treatment also theoretical basis targets.

Language: Английский

Effects of circulating RNAs on tumor metabolism in lung cancer (Review) DOI Open Access

Pengfei Zhao,

Zhengfeng Zhu, Xi Zheng

et al.

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 11

Published: Feb. 27, 2025

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis abnormal lipid amino acid to obtain energy nutrients for growth, proliferation drug resistance. Circular RNAs (circRNAs), a class non-coding RNAs, serve important biological roles in growth tumors. Functionally, circRNAs act as molecular sponges that absorb microRNAs (miRNAs) RNA-binding proteins protein scaffolds regulate gene transcription translation through maintenance mRNA stability. In addition, are regulators tumor promote mediating proliferation, metastasis induction chemoresistance. Results previous studies reveal may key role regulating metabolic processes miRNA sponging alternative mechanisms. demonstrate potential therapeutic targets cancer. The present study aimed review effects cancer provide novel insights into clinical treatment also theoretical basis targets.

Language: Английский

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