Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy DOI Creative Commons

Babu Santha Aswani,

Anjana Sajeev, Mangala Hegde

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: 225, P. 112045 - 112045

Published: March 11, 2025

Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated developing effective therapeutics target cancer cells. One promising strategy involves inducing cellular senescence, a complex state in which cells exit cell cycle. Senescence has profound effects on both physiological pathological processes, influencing systems through secreted factors that affect surrounding distant Among these exosomes, small extracellular vesicles play crucial roles communication, development, defense, can contribute conditions. Recently, there been increasing interest engineering exosomes as precise drug delivery vehicles, capable targeting specific or intracellular components. Studies have emphasized significant role from senescent progression therapy. Notably, chemotherapeutic agents alter tumor microenvironment, induce trigger immune responses exosome-mediated cargo transfer. This review explores intricate relationship between cancer, examining how different eliminate promote resistance. It also investigates molecular mechanisms signaling pathways driving highlighting current challenges proposing future perspectives uncover new therapeutic strategies for treatment.

Language: Английский

Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy DOI Creative Commons

Babu Santha Aswani,

Anjana Sajeev, Mangala Hegde

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: 225, P. 112045 - 112045

Published: March 11, 2025

Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated developing effective therapeutics target cancer cells. One promising strategy involves inducing cellular senescence, a complex state in which cells exit cell cycle. Senescence has profound effects on both physiological pathological processes, influencing systems through secreted factors that affect surrounding distant Among these exosomes, small extracellular vesicles play crucial roles communication, development, defense, can contribute conditions. Recently, there been increasing interest engineering exosomes as precise drug delivery vehicles, capable targeting specific or intracellular components. Studies have emphasized significant role from senescent progression therapy. Notably, chemotherapeutic agents alter tumor microenvironment, induce trigger immune responses exosome-mediated cargo transfer. This review explores intricate relationship between cancer, examining how different eliminate promote resistance. It also investigates molecular mechanisms signaling pathways driving highlighting current challenges proposing future perspectives uncover new therapeutic strategies for treatment.

Language: Английский

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