Platelet Rich Plasma Loaded Multifunctional Hydrogel Accelerates Diabetic Wound Healing via Regulating the Continuously Abnormal Microenvironments

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(28)

Published: July 12, 2023

Continuous oxidative stress and cellular dysfunction caused by hyperglycemia are distinguishing features of diabetic wounds. It has been a great challenge to develop smart dressing that can accelerate wound healing through regulating abnormal microenvironments. In this study, platelet rich plasma (PRP) loaded multifunctional hydrogel with reactive oxygen species (ROS) glucose dual-responsive property is reported. be conveniently prepared PRP, dopamine (DA) grafted alginate (Alg-DA), 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol (ABO) conjugated hyaluronic acid (HA-ABO) ionic crosslinks, hydrogen-bond interactions, boronate ester bonds. The possesses injectability, moldability, tissue adhesion, self-healing, low hemolysis, hemostasis performances. Its excellent antioxidant create microenvironment for other biological events. Under an and/or state, the degrade at accelerated rate release variety cytokines derived from activated blood platelets. result series positive changes favorable healing, including fast anti-inflammation, macrophage polarization toward M2 phenotype, promoted migration proliferation fibroblasts, as well expedited angiogenesis. This work provides efficient strategy chronic management offers alternative developing new-type PRP-based bioactive dressing.

Language: Английский

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Targeted release of soybean peptide from CMC/PVA hydrogels in simulated intestinal fluid and their pharmacokinetics

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120713 - 120713

Published: Feb. 20, 2023

Language: Английский

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Antioxidative and antibacterial gallium (III)-phenolic coating for enhanced osseointegration of titanium implants via pro-osteogenesis and inhibiting osteoclastogenesis

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122268 - 122268

Published: Aug. 7, 2023

Language: Английский

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Preparation of Biocompatible Manganese Selenium-Based Nanoparticles with Antioxidant and Catalytic Functions

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4498 - 4498

Published: June 1, 2023

The specificity of the tumor microenvironment (TME) severely limits effectiveness treatment. In this study, we prepared a composite nanoparticle manganese dioxide and selenite by one-step redox method, their stability under physiological conditions was improved with bovine serum protein modification to obtain MnO

Language: Английский

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Adsorption of Zn2+ ion by macadamia nut shell biochar modified with carboxymethyl chitosan and potassium ferrate

Journal of environmental chemical engineering, Journal Year: 2023, Volume and Issue: 11(3), P. 110150 - 110150

Published: May 17, 2023

Language: Английский

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