International Journal of Food Sciences and Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: April 23, 2025
Various
types
of
non-digestible
oligosaccharides
(NDOs)
have
attracted
tremendous
interest
due
to
their
healthy
functions
in
regulating
intestinal
microbiota.
Whereas
the
specificity
different
NDOs
towards
certain
bacterial
species
remains
unclear.
In
this
study,
konjac
manna-oligosaccharides
(KMOS)
were
selected
from
eight
through
vitro
faecal
batch
fermentation.
KMOS
accelerated
increase
recognised
probiotics
(Bifidobacterium
spp.
and
Akkermansia
spp.)
achieved
highest
productions
lactic
acid
total
short-chain
fatty
acids
(42.0
mM).
β-Mannosidase
β-glucosidase
played
important
role
utilisation
KMOS,
mannobiose
glucosyl-mannobiose
preferentially
consumed
by
pure
culture,
was
tested
with
nine
Bifidobacterium
strains.
Amongst,
increased
cell
density
B.
animalis
BB-12
3.5
folds
improved
its
adhesion
ability
Caco-2
3.1
folds,
suggesting
that
may
be
developed
as
a
potential
synbiotic
combination.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(6), P. 1068 - 1068
Published: March 19, 2025
The
issue
of
antibiotic-resistant
bacterial
infections,
coupled
with
the
rise
in
viral
pandemics
and
slow
development
new
antibacterial
antiviral
treatments,
underscores
critical
need
for
novel
strategies
to
mitigate
spread
drug-resistant
pathogens,
enhance
efficacy
existing
therapies,
accelerate
discovery
deployment
innovative
antimicrobial
solutions.
One
promising
approach
address
these
challenges
is
dietary
supplementation
non-digestible
oligosaccharides
(NDOs).
NDOs,
including
human
milk
(HMOs),
play
a
vital
role
shaping
sustaining
healthy
gut
microbiota.
Beyond
stimulating
growth
activity
beneficial
bacteria,
NDOs
can
also
interact
directly
pathogenic
bacteria
viruses.
Their
properties
arise
from
their
unique
interactions
pathogens
ability
modulate
host’s
immune
system.
function
as
decoy
receptors,
inhibit
pathogen
growth,
bind
toxins,
stimulate
host
response,
exhibit
anti-biofilm
properties,
barrier
protection.
However,
notable
gap
exists
comprehensive
assessment
vivo
clinical
data
on
this
topic.
This
review
aims
provide
an
in-depth
overview
evidence
related
effects
various
HMOs,
focus
discussing
possible
mechanisms
action.
International Journal of Food Sciences and Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: April 23, 2025
Various
types
of
non-digestible
oligosaccharides
(NDOs)
have
attracted
tremendous
interest
due
to
their
healthy
functions
in
regulating
intestinal
microbiota.
Whereas
the
specificity
different
NDOs
towards
certain
bacterial
species
remains
unclear.
In
this
study,
konjac
manna-oligosaccharides
(KMOS)
were
selected
from
eight
through
vitro
faecal
batch
fermentation.
KMOS
accelerated
increase
recognised
probiotics
(Bifidobacterium
spp.
and
Akkermansia
spp.)
achieved
highest
productions
lactic
acid
total
short-chain
fatty
acids
(42.0
mM).
β-Mannosidase
β-glucosidase
played
important
role
utilisation
KMOS,
mannobiose
glucosyl-mannobiose
preferentially
consumed
by
pure
culture,
was
tested
with
nine
Bifidobacterium
strains.
Amongst,
increased
cell
density
B.
animalis
BB-12
3.5
folds
improved
its
adhesion
ability
Caco-2
3.1
folds,
suggesting
that
may
be
developed
as
a
potential
synbiotic
combination.
