ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(7), P. 2725 - 2737
Published: June 21, 2023
The
conventional
pectin
delivery
systems
in
the
colon
are
often
impaired
by
a
slow
release
rate.
Nanostructured
particles,
especially
porous
ones,
have
gained
popularity
as
drug
owing
to
their
high
mass
transfer
efficiency.
In
this
research,
particles
were
synthesized
carriers
(using
indomethacin
model
drug)
via
template-assisted
spray
drying.
Specific
surface
areas
of
been
improved
up
203
m2
g-1
compared
with
nonporous
(1
g-1).
structure
shortened
diffusion
path
and
rate
molecules.
Additionally,
predominant
mechanism
from
is
Fickian
diffusion,
which
different
combination
erosion
observed
for
particles.
As
result,
these
drug-loaded
demonstrated
rapid
rates
three
times
faster
than
Control
could
be
achieved
changing
This
strategy
an
efficient
means
synthesize
allowing
into
colonic
target.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: June 17, 2024
Abstract
Microgels
prepared
from
natural
or
synthetic
hydrogel
materials
have
aroused
extensive
attention
as
multifunctional
cells
drug
carriers,
that
are
promising
for
tissue
engineering
and
regenerative
medicine.
can
also
be
aggregated
into
microporous
scaffolds,
promoting
cell
infiltration
proliferation
repair.
This
review
gives
an
overview
of
recent
developments
in
the
fabrication
techniques
applications
microgels.
A
series
conventional
novel
strategies
including
emulsification,
microfluidic,
lithography,
electrospray,
centrifugation,
gas-shearing,
three-dimensional
bioprinting,
etc.
discussed
depth.
The
characteristics
microgels
microgel-based
scaffolds
culture
delivery
elaborated
with
emphasis
on
advantages
these
carriers
therapy.
Additionally,
we
expound
ongoing
foreseeable
current
limitations
their
aggregate
field
biomedical
engineering.
Through
stimulating
innovative
ideas,
present
paves
new
avenues
expanding
application
techniques.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100610 - 100610
Published: March 15, 2023
Repurposing
clinically
approved
drugs
to
construct
novel
nanomedicines
is
currently
a
very
attractive
therapeutic
approach.
Selective
enrichment
of
anti-inflammatory
and
reactive
oxygen
species
(ROS)
scavenging
at
the
region
inflammation
by
stimuli-responsive
oral
nanomedicine
an
effective
strategy
for
treatment
inflammatory
bowel
disease
(IBD).
This
study
reports
nanomedicine,
which
based
on
excellent
drug
loading
free
radical
ability
mesoporous
polydopamine
nanoparticles
(MPDA
NPs).
By
initiating
polyacrylic
acid（PAA）polymerization
its
surface,
"core-shell"
structure
nano-carrier
with
pH
response
constructed.
Then,
under
alkaline
conditions,
using
π-π
stacking
hydrophobic
interaction
between
sulfasalazine
(SAP)
MPDA,
(PAA@MPDA-SAP
NPs)
loaded
efficiently
(928
μ
g
mg-1)
SAP
was
successfully
formed.
Our
results
reveal
that
PAA@MPDA-SAP
NPs
can
pass
through
upper
digestive
tract
smoothly
finally
accumulate
in
inflamed
colon.
Through
synergistic
effect
anti-inflammation
antioxidation,
it
effectively
reduce
expression
pro-inflammatory
factors
enhance
intestinal
mucosal
barrier,
significantly
alleviate
symptoms
colitis
mice.
Furthermore,
we
confirmed
have
good
biocompatibility
repair
induction
human
colonic
organoids.
In
summary,
this
work
provides
theoretical
basis
development
IBD
therapy.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 23, 2023
Abstract
Patients
with
inflammatory
bowel
disease
(IBD)
always
suffer
from
severe
abdominal
pain
and
appear
to
be
at
high
risk
for
colorectal
cancer.
Recently,
the
co-delivery
of
targeted
drugs
gut
microbiota
has
developed
into
an
attractive
strategy.
A
new
strategy
using
fermentation
overcome
interspace
diffuse
resistance
mucus
layer
control
drug
release
in
sites
(IBS
sites)
not
yet
been
available.
Here,
we
designed
alginate
hydrogel
microsphere
encapsulating
bifidobacterium
(Bac)
drug-modified
nanoscale
dietary
fibers
(NDFs).
The
is
responsible
protecting
acidic
multi-enzymatic
environments
delivering
colorectum.
Subsequently,
Bac
by
digesting
NDFs
proteins
as
carbon
nitrogen
sources
can
promote
play
a
probiotic
role
microbiota.
In
vitro
evidence
indicated
that
small-sized
NDF
(NDF-1)
could
significantly
short-chain
fatty
acid
(SCFA)
expression.
Notably,
NDF-1
microspheres
showed
boost
5-ASA
IBS
sites,
resulting
amelioration
inflammation
remodeling
chronic
colitis
mice.
This
study
controlled
system
based
on
microbial
treatment
IBD.
Biomacromolecules,
Journal Year:
2023,
Volume and Issue:
24(5), P. 2250 - 2263
Published: April 17, 2023
The
pathogenesis
of
inflammatory
bowel
diseases
(IBDs)
including
ulcerative
colitis
(UC)
and
Crohn's
disease
is
extremely
cloudy.
Maintaining
the
level
remission
lesions
in
default
treatment
attitude
at
present.
Epithelial
barrier
restoration
considered
as
same
important
strategy
colonic
targeted
drug
delivery
UC
treatment.
In
this
paper,
we
developed
a
multilayer
natural
polysaccharide
microsphere
(pectin/chitosan/alginate)
with
pH
enzyme
dual
sensitivity
to
reduce
loss
medication
upper
digestive
tract
preferentially
adhere
exposed
epithelial
cells
tissues
by
electrostatic
forces
for
efficiently
Olsalazine
an
was
loaded
chitosan
layer
realized
pH-responsive
release.
Furthermore,
microspheres
exhibited
excellent
capability
suppressing
harmful
flora
bio-adhesion
effect
extend
duration
local
medicine.
vivo
anti-colitis
study,
downregulated
levels
pro-inflammatory
factors
increase
tight
junction
protein
indicated
anti-inflammation
olsalazine-loaded
microspheres.
summary,
these
results
showed
that
could
be
powerful
candidate
system
therapy.
