Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(7), P. 1093 - 1093
Published: July 3, 2023
Nasal
irrigation
is
thought
to
decrease
the
viral
load
present
in
nasal
cavity.
Our
aim
was
assess
effect
of
a
hypertonic
seawater
solution
[with
algal
and
herbal
natural
ingredients
(Sinomarin®)]
on
nasopharynx
patients
hospitalized
with
severe
COVID-19
pneumonia.
We
conducted
prospective,
randomized,
controlled
trial
from
June
2022
December
2022.
allocated
56
pneumonia
into
two
groups
(28
each
group)—the
group
[nasal
irrigations
(Sinomarin®)
every
4
h
for
16
per
day,
consecutive
days]
control
(no
irrigations).
A
second
nasopharyngeal
swab
collected
48
after
baseline
(8
last
wash
group)
estimate
SARS-CoV-2
as
determined
by
cycle
threshold
(Ct)
values.
In
group,
mean
Ct
values
significantly
increased
days
initial
measurement
[ΔCt
48−0
=
3.86
±
3.03
cycles,
p
<
0.001
(95%CI:
2.69
5.04)].
No
significant
differences
were
observed
−0.14
4.29,
0.866
−1.80
−1.52)].
At
follow-up,
17
had
negative
test
results
compared
only
9
(p
0.03).
containing
decreased
detection
time
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(1), P. 27 - 27
Published: Jan. 7, 2025
Fucoidan
is
a
sulfated
polysaccharide
found
in
brown
seaweed.
Due
to
its
reported
biological
activities,
including
antiviral,
antibacterial
and
anti-inflammatory
it
has
garnered
significant
attention
for
potential
biomedical
applications.
However,
the
direct
relationship
between
fucoidan
extracts'
chemical
structures
bioactivities
unclear,
making
extremely
challenging
predict
whether
an
extract
will
possess
given
bioactivity.
This
further
complicated
by
lack
of
uniformity
recent
literature
terms
assessment
reporting
properties,
yield
composition
(e.g.,
sulfate,
fucose,
uronic
acid
monosaccharide
contents).
These
inconsistencies
pose
challenges
when
directly
comparing
extraction
techniques
across
studies.
review
collected
data
on
contents
properties
from
selection
available
Where
information
was
unavailable
directly,
efforts
were
made
extrapolate
data.
approach
enabled
comprehensive
examination
correlation
characteristics
resulting
extracts.
A
holistic
framework
presented
methods,
outlining
key
heuristics
consider
capturing
broader
context
seaweed
bioprocess.
Future
work
should
focus
developing
knowledge
within
these
heuristic
categories,
such
as
creation
technoeconomic
models
each
process.
allow
robust
process
that
integrates
scale,
cost
constraints
into
decision
making.
Key
quality
attributes
biologically
active
are
proposed,
areas
future
research
identified,
studies
specific
aimed
at
elucidating
fucoidan's
mechanism
action.
also
sets
out
required
standardize
Standardization
could
positively
enhance
depth
extracts,
enabling
relationships
physical,
bioactive
be
identified.
Recommendations
best
practices
production
high-quality
with
desirable
yield,
bioactivity
highlighted.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(5), P. 300 - 300
Published: May 16, 2023
Cancer
is
one
of
the
most
worldwide
spread
diseases
and
causes
maximum
death.
Treatment
cancer
depends
on
host
immune
system
type
drugs.
The
inefficiency
conventional
treatments
as
a
result
drug
resistance,
nontargeted
delivery,
chemotherapy-related
negative
side
effects
has
caused
bioactive
phytochemicals
to
come
into
focus.
As
result,
recent
years
have
seen
an
increase
in
research
screening
identifying
natural
compounds
with
anticancer
properties.
Recent
studies
isolation
use
polysaccharides
derived
from
various
marine
algal
species
revealed
variety
biological
activities,
including
antioxidant
Ulvan
polysaccharide
green
seaweeds
Ulva
family
Ulvaceae.
It
been
demonstrated
potent
anti-inflammatory
properties
through
modulation
antioxidants.
vital
understand
mechanisms
underlying
biotherapeutic
activities
its
role
immunomodulation.
In
this
context,
we
reviewed
ulvan
based
apoptotic
immunomodulatory
activity.
Additionally,
also
focused
pharmacokinetic
review.
conceivable
candidate
for
therapeutic
agent
could
be
used
boost
immunity.
Moreover,
it
may
established
once
action
are
understood.
Due
high
food
nutritive
values,
can
possible
dietary
supplement
patients
near
future.
This
review
provide
fresh
perspectives
potential
novel
ulvan,
reveal
brand-new
cancer-prevention
strategy,
improve
human
health.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(3), P. 715 - 715
Published: Jan. 24, 2023
Seaweed-derived
bioactive
compounds
are
regularly
employed
to
treat
human
diseases.
Sulfated
polysaccharides
potent
chemotherapeutic
or
chemopreventive
medications
since
it
has
been
discovered.
They
have
exhibited
anti-cancer
properties
by
enhancing
immunity
and
driving
apoptosis.
Through
dynamic
modulation
of
critical
intracellular
signalling
pathways,
such
as
control
ROS
generation
preservation
essential
cell
survival
death
processes,
sulfated
polysaccharides'
antioxidant
immunomodulatory
potentials
contribute
their
disease-preventive
effectiveness.
provide
low
cytotoxicity
good
efficacy
therapeutic
outcomes
via
apoptosis
in
cancer.
Understanding
how
affect
cancer
cells
molecular
involvement
pathways
will
showcase
a
new
way
chemoprevention.
In
this
review,
the
significance
autophagy-modulating
emphasized,
well
future
direction
enhanced
nano-formulation
for
greater
clinical
efficacy.
Moreover,
review
focuses
on
recent
findings
about
possible
mechanisms
use
polysaccharides,
potential
drugs,
proposed
action
drive
diverse
malignancies.
Because
unique
physicochemical
biological
properties,
ideal
ingredients,
which
can
improve
function
application
disease.
However,
there
is
gap
literature
regarding
functionalities
polysaccharide-based
delivery
systems
functional
Furthermore,
preclinical
trials
reveal
drug's
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2615 - 2615
Published: Jan. 30, 2023
The
marine
polysaccharide
fucoidan
(FUC)
is
a
promising
polymer
for
pharmaceutical
research
and
development
of
novel
drug
delivery
systems
with
modified
release
targeted
delivery.
presence
sulfate
group
in
the
makes
FUC
an
excellent
candidate
formation
interpolyelectrolyte
complexes
(PECs)
various
polycations.
However,
due
to
structural
diversity
FUC,
design
FUC-based
nanoformulations
challenging.
This
review
describes
main
strategies
use
PECs
develop
improved
biopharmaceutical
properties,
including
nanocarriers
form
FUC-chitosan
pH-sensitive
oral
delivery,
systems,
polymeric
nanoparticles
hydrophobic
(e.g.,
FUC-zein
PECs,
core-shell
structures
obtained
by
layer-by-layer
self-assembly
method,
self-assembled
hydrophobically
particles).
importance
complex
study
structure,
process
based
on
it
obtaining
reproducible
desired
also
discussed.
Plants,
Journal Year:
2023,
Volume and Issue:
12(13), P. 2445 - 2445
Published: June 25, 2023
Brown
macroalgae
represent
one
of
the
most
proliferative
groups
living
organisms
in
aquatic
environments.
Due
to
their
abundance,
they
often
cause
problems
and
terrestrial
ecosystems,
resulting
health
humans
death
various
species.
To
resolve
this,
application
Sargassum
has
been
sought
different
research
areas,
such
as
food,
pharmaceuticals,
cosmetics,
since
is
an
easy
target
for
study
simple
obtain.
In
addition,
its
high
content
biocompounds,
polysaccharides,
phenols,
amino
acids,
among
others,
attracted
attention.
One
valuable
components
brown
which
present
interesting
bioactivities,
antiviral,
antimicrobial,
antitumoral,
others.
There
a
wide
variety
methods
extraction
currently
used
obtain
these
supercritical
fluid
(SFE),
pressurized
liquid
(PLE),
subcritical
water
(SCWE),
ultrasound-assisted
(UAE),
enzyme-assisted
(EAE),
microwave-assisted
(MAE).
Therefore,
this
work
covers
current
information
on
extraction,
well
purification
polysaccharide
from
that
able
be
utilized
alginates,
fucoidans,
laminarins.
compilation
bioactivities
involving
algae
polysaccharides
vivo
vitro
studies
also
presented,
along
with
challenges
marketing
Sargassum-based
products
are
commercially
available.
