Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(18), P. 10406 - 10419
Published: April 25, 2024
The
impact
of
leptin
resistance
on
intestinal
mucosal
barrier
integrity,
appetite
regulation,
and
hepatic
lipid
metabolism
through
the
microbiota–gut–brain–liver
axis
has
yet
to
be
determined.
Water
extract
Phyllanthus
emblica
L.
fruit
(WEPE)
its
bioactive
compound
gallic
acid
(GA)
effectively
alleviated
methylglyoxal
(MG)-triggered
in
vitro.
Therefore,
this
study
investigated
how
WEPE
GA
intervention
relieve
resistance-associated
dysfunction
mucosa,
appetite,
accumulation
high-fat
diet
(HFD)-fed
rats.
results
showed
that
significantly
reduced
tissues
(jejunum,
brain,
liver)
MG-evoked
resistance,
malondialdehyde
(MDA),
proinflammatory
cytokines,
SOCS3,
orexigenic
neuropeptides,
increasing
receptor,
tight
junction
proteins,
antimicrobial
peptides,
anorexigenic
excretion
fecal
triglyceride
(TG),
short-chain
fatty
acids
(SCFAs)
via
a
positive
correlation
with
Allobaculum
Bifidobacterium
microbiota.
These
novel
findings
suggest
holds
potential
as
functional
food
ingredient
for
alleviating
obesity
complications.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
281, P. 116612 - 116612
Published: June 18, 2024
T-2
toxin
is
one
of
trichothecene
mycotoxins,
which
can
impair
appetite
and
decrease
food
intake.
However,
the
specific
mechanisms
for
toxin-induced
anorexia
are
not
fully
clarified.
Multiple
research
results
had
shown
that
gut
microbiota
have
a
significant
effect
on
regulation.
Hence,
this
study
purposed
to
explore
potential
interactions
regulate
factors
in
induced
by
toxin.
The
divided
mice
into
control
group
(CG,
0
mg/kg
BW
toxin)
toxin-treated
(TG,
1
toxin),
oral
gavage
4
weeks,
construct
subacute
poisoning
mouse
model.
This
data
proved
was
able
induce
an
increased
contents
gastrointestinal
hormones
(CCK,
GIP,
GLP-1
PYY),
neurotransmitters
(5-HT
SP),
as
well
pro-inflammatory
cytokines
(IL-1β,
IL-6
TNF-α)
serum
mice.
disturbed
composition
microbiota,
especially,
Faecalibaculum
Allobaculum,
positively
correlated
with
CCK,
GLP-1,
5-HT,
IL-1β,
TNF-α,
played
certain
role
regulating
host
appetite.
In
conclusion,
changes
(especially
increase
abundance
Allobaculum)
promote
upregulation
hormones,
neurotransmitters,
cytokines,
may
be
mechanism
anorexia.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
The
complex
composition
of
traditional
Chinese
medicines
(TCMs)
has
posed
challenges
for
in‐depth
study
and
global
application,
despite
their
abundance
bioactive
compounds
that
make
them
valuable
resources
disease
treatment.
To
overcome
these
obstacles,
it
is
essential
to
modernize
TCMs
by
focusing
on
precise
This
involves
elucidating
the
structure‐activity
relationships
within
compositions,
ensuring
accurate
in
vivo
delivery,
monitoring
delivery
process.
review
discusses
research
progress
precision
treatment
from
three
perspectives:
spatial
multi‐omics
technology
therapeutic
activity,
carrier
systems
medical
imaging
visualizing
aim
establish
a
novel
paradigm
advances
therapy
TCMs.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 29, 2025
Alzheimer’s
disease
(AD)
is
one
of
the
most
common
diseases
central
nervous
system
in
middle-aged
and
elderly
population.
It
a
neurodegenerative
disorder,
its
main
clinical
symptoms
include
loss
established
memories,
decline
learning
capacity,
buildup
β-amyloid
peptides.
The
often
accompanied
by
changes
formation
neurofibrillary
tangles.
However,
number
drugs
available
for
treatment
AD
remains
limited.
Currently,
existing
medications
are
not
effective
completely
curing
or
stopping
progression.
Due
to
their
excellent
biocompatibility
biodegradability,
polymers
have
been
widely
used
as
drug
delivery
carriers
various
fields
including
cancer
therapy
wound
healing.
use
enables
targeted
prolonged
release
profiles.
In
recent
years,
researchers
made
significant
progress
utilizing
such
polyethylene
glycol,
poly
(lactic-co-glycolic
acid)
(PLGA),
chitosan
(CS)
deliver
blood-brain
barrier
receptor
ligands
AD.
Moreover,
many
with
inherent
therapeutic
properties
developed,
already
marketed
GV-971
well
experimental
PLGA
CS
oligosaccharide.
This
review
summarizes
applications
over
past
few
years
highlights
current
limitations
help
better
understand
advancements
polymer
development
identify
future
research
directions.
Cell Proliferation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
ABSTRACT
In
spite
of
great
advances
in
modern
medicine,
there
are
a
few
effective
strategies
for
the
treatment
neurodegenerative
diseases
characterised
by
neuron
loss
or
degeneration.
This
results
from
complex
pathogenesis
and
limited
drug
uptake
brain
due
to
presence
blood‐brain
barrier.
Nanoparticle‐based
delivery
systems
expected
improve
utilisation.
Polymeric
nanoparticles
represent
promising
carriers
their
unique
advantages
such
as
good
biodegradability
biocompatibility,
flexibility
surface
modification
nontoxicity.
addition,
genetic
drugs
may
stop
progression
at
level
even
avoid
irreversible
damage
central
nervous
system.
this
review,
an
overview
studies
on
polymer‐based
system
typical
diseases,
especially
Alzheimer's
Parkinson's
is
described.
Meanwhile,
applications
gene
these
disorders
discussed.
And
challenges
future
perspectives
development
polymeric
concluded.
ABSTRACT
Aims
The
TiaoGanXiaoZhi
formula
(TGXZ),
a
traditional
Chinese
medicine,
has
been
shown
to
alleviate
the
progression
of
metabolic‐associated
fatty
liver
disease
(MAFLD)
clinically.
However,
its
underlying
mechanism
remains
unclear.
This
study
aimed
investigate
effects
and
mechanisms
TGXZ
in
treating
MAFLD
mouse
models.
Methods
model
was
established
using
high‐fat
diet
5%
fructose
water
over
16
weeks.
At
Week
8,
mice
exhibited
significant
steatosis,
inflammation,
insulin
resistance.
A
total
42
were
divided
into
normal
feed
(NFD)
group
(
n
=
18)
(HFD)
24).
Six
from
each
killed
at
8
for
serological
histopathological
assessments.
remaining
allocated
NFD
6),
HFD
+
Placebo
6)
groups.
(or
placebo)
administered
clinical
equivalent
dose
7.699
g/(kg·d)
respective
groups,
while
groups
received
distilled
water.
Daily
gavage
started
9.
16,
after
fasting,
body
weight
condition
recorded,
euthanized
with
pentobarbital
sodium.
Liver
tissue
collected
further
analysis,
feces
stored
−80°C.
Data
graphed
GraphPad
Prism
8.0.0
analyzed
SPSS
Statistics
25.0.
Results
are
expressed
as
mean
±
standard
deviation.
Statistical
comparisons
made
Student's
t
‐test
two
one‐way
ANOVA
more
than
significance
set
p
<
0.05.
Compared
group,
treatment
significantly
downregulated
white
adipose
(1.61
0.66
vs.
3.06
0.34
g,
0.0010),
(1.22
0.16
1.98
0.39
0.0031),
levels
alanine
aminotransferase
(20.6
3.4
46.1
12.3
U/L,
aspartate
(99.9
19.1
168.4
34.3
0.0014),
cholesterol
(2.95
0.56
4.38
mmol/L,
0.0053),
triglycerides
(2.25
0.41
4.18
0.67
low‐density
lipoprotein
(0.66
0.11
1.41
0.52
0.0073),
bile
acid
(0.71
2.18
0.61
0.0017),
except
high‐density
(2.41
0.81
2.55
0.31
0.5655).
transcriptome,
fecal
microbiota
sequencing,
lipidomics
analysis
demonstrated
that
improved
expression
genes
related
lipid
metabolism,
alleviated
intestinal
disorders,
mitigated
disturbances
caused
by
MAFLD.
Conclusions
Our
effectively
inhibitory
on
may
be
attributed
regulation
gut
microbiota,
hepatic
inflammation.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2025,
Volume and Issue:
24(2)
Published: March 1, 2025
Plant-derived
polysaccharides
have
emerged
as
sustainable
biopolymers
for
fabricating
nanoparticles
(polysaccharide-based
nanomaterials
[PS-NPs]),
presenting
unique
opportunities
to
enhance
food
functionality
and
human
health.
PS-NPs
exhibit
exceptional
biocompatibility,
biodegradability,
structural
versatility,
enabling
their
integration
into
functional
foods
positively
influence
gut
microbiota.
This
review
explores
the
mechanisms
of
interaction
with
microbiota,
highlighting
ability
promote
beneficial
microbial
populations,
such
Lactobacilli
Bifidobacteria,
stimulate
production
short-chain
fatty
acids.
Key
synthesis
stabilization
methods
are
discussed,
focusing
on
role
in
improving
bioavailability,
stability,
gastrointestinal
delivery
bioactive
compounds
systems.
The
potential
address
challenges
science,
including
enhancing
nutrient
absorption,
mitigating
intestinal
dysbiosis,
supporting
through
innovative
nanotechnology,
is
critically
evaluated.
Barriers
enzymatic
degradation
physicochemical
stability
analyzed,
alongside
strategies
optimize
within
complex
matrices.
systems
offers
a
novel
approach
modulate
improve
health,
drive
development
next-generation
foods.
Future
research
should
focus
bridging
knowledge
gaps
metagenomic
metabolomic
profiling
PS-NPs,
optimizing
design
diverse
applications,
advancing
health-promoting
innovations.
