Food biomacromolecules.,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
In
the
recent
years,
various
strains
of
gut
microbiota
have
been
discovered
to
possess
significant
therapeutic
potential,
they
are
defined
as
next‐generation
probiotics
(NGPs).
Akkermansia
,
Faecalibacterium
Bacteriodes
Eubacterium,
and
Bifidobacteria
among
typical
NGP
which
exhibit
several
interesting
bioactivities
live
biotherapeutics.
However,
some
extremely
sensitive
oxygen,
such
prausnitzii
.
This
hinders
their
cultivation
large‐scale
production.
Therefore,
it
is
essential
develop
a
strategy
protect
them
during
production,
storage,
colonic
administration.
review,
highlights
key
developed
in
alongside
encapsulation
strategies
used
them.
The
primary
criterion
for
selecting
encapsulating
techniques
feasibility
be
performed
under
strictly
anaerobic
conditions.
Various
processes
selected
according
physical
forms
products,
including
liquid,
gel,
solid
forms,
well
final
shaping
product.
critical
factors
materials
include
biocompatibility,
safety,
effective
oxygen
barrier
properties,
an
optimal
release
profile
gastrointestinal
tract.
review
discusses
protection
aimed
at
improving
survival
thereby
effectiveness
NGPs.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Abstract
Colorectal
cancer
(CRC)
ranks
as
the
third
most
prevalent
worldwide.
It
is
associated
with
imbalanced
gut
microbiota.
Probiotics
can
help
restore
this
balance,
potentially
reducing
risk
of
CRC.
However,
hostile
environment
and
constant
changes
in
gastrointestinal
tract
pose
significant
challenges
to
efficient
delivery
probiotics
colon.
Traditional
methods
are
often
insufficient
due
their
low
viability
lack
targeting.
To
address
these
challenges,
researchers
increasingly
focusing
on
innovative
encapsulation
technologies.
One
such
approach
single‐cell
encapsulation,
which
involves
applying
nanocoatings
individual
probiotic
cells.
This
technique
improve
resistance
harsh
environment,
enhance
mucosal
adhesion,
facilitate
targeted
release,
thereby
increasing
effectiveness
delivery.
article
reviews
latest
developments
for
CRC
treatment,
emphasizing
potential
benefits
emerging
techniques.
also
analyzes
compares
advantages
disadvantages
current
Furthermore,
it
elucidates
underlying
mechanisms
through
prevent
treat
CRC,
evaluates
efficacy
safety
treatment
adjuvant
therapy,
discusses
future
directions
prevention.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 14, 2024
Introduction
In
an
era
increasingly
defined
by
the
challenge
of
antibiotic
resistance,
this
study
offers
groundbreaking
insights
into
antibacterial
properties
two
distinct
Lactiplantibacillus
plantarum
strains,
TE0907
and
TE1809,
hailing
from
unique
ecosystem
Bufo
gargarizans
.
It
uniquely
focuses
on
elucidating
intricate
components
mechanisms
that
empower
these
strains
with
their
notable
capabilities.
Methods
The
research
employs
a
multi-omics
approach,
including
agar
diffusion
tests
to
assess
efficacy
adhesion
assays
HT-29
cells
understand
preliminary
mechanisms.
Additionally,
gas
chromatography-mass
spectrometry
(GC-MS)
is
employed
analyze
production
organic
acids,
notably
acetic
acid,
whole-genome
sequencing
utilized
identify
genes
linked
biosynthesis
antibiotics
bacteriocin-coding
domains.
Results
comparative
analysis
highlighted
exceptional
mean
inhibitory
zones
measured
at
14.97
15.98
mm,
respectively.
A
pivotal
discovery
was
significant
synthesis
acid
in
both
demonstrated
robust
correlation
coefficient
(cor
≥
0.943),
linking
its
abundance
antimicrobial
efficiency.
Genomic
exploration
uncovered
diverse
range
elements
involved
similar
tetracycline
vancomycin
potential
regions
encoding
bacteriocins,
Enterolysin
Plantaricin.
Conclusion
This
illuminates
remarkable
intrinsic
L.
sourced
B.
findings
underscore
strains'
extensive
biochemical
enzymatic
armamentarium,
offering
valuable
role
antagonizing
enteric
pathogens.
These
results
lay
down
comprehensive
analytical
foundation
for
clinical
deployment
safeguarding
animal
gut
health,
thereby
enriching
our
understanding
probiotic
bacteria
realm
interventions.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(45)
Published: May 25, 2024
Abstract
Cells
exhibit
diverse
structural
formations
such
as
biofilms
and
spores,
enabling
them
to
acquire
novel
functionalities.
Many
of
these
structures
display
biomacromolecules,
including
enzymes,
tethered
cell
walls
support
various
extracellular
processes.
Alternatively,
encapsulating
single
cells
with
polymer
coatings
offers
a
strategy
that
circumvents
the
need
for
genetic
engineering
while
imparting
artificial
functionalities
cells.
Here,
universal
method
is
presented
gram‐negative
microbes
polymeric
based
on
ancestral
gall
ink
formed
by
tannic
acid‐iron
complexes.
As
result,
synthetic
spores
are
achieved
selectively
bind
His‐tagged
enzymes
through
formation
unprecedented
galloyl/imidazole‐Fe
2+
complexes
via
ligand
substitution
demonstrated
density
functional
theory.
These
thickness
41.5
±
4.2
nm
stiffness
6.0
3.5
GPa
serve
biocatalytic
materials
one‐pot
oxidative
amination
diols
into
amino
alcohols,
facilitated
cooperative
catalysis
between
intracellular
endogenous
or
recombinant
oxidoreductases,
an
transaminase
from
Pseudomonas
fluorescens
displayed
at
spore
surface.
maintain
their
performance
in
three
consecutive
batch
cycles.
Integrating
isolated
onto
surface
engineered
coated
polymers
opportunities
biology,
advancing
efficiency
biosynthetic
cascades
solid‐state
environments.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 10917 - 10940
Published: Oct. 1, 2024
Diabetes
Mellitus
(DM)
is
a
substantial
health
concern
worldwide,
and
its
incidence
progressively
escalating.
Conventional
pharmacological
interventions
frequently
entail
undesirable
side
effects,
while
probiotics
offer
benefits,
they
are
hindered
by
constraints
such
as
diminished
stability
effectiveness
within
the
gastrointestinal
milieu.
Given
these
complications,
advent
of
bioengineered
promising
alternative
for
DM
management.
Food biomacromolecules.,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
In
the
recent
years,
various
strains
of
gut
microbiota
have
been
discovered
to
possess
significant
therapeutic
potential,
they
are
defined
as
next‐generation
probiotics
(NGPs).
Akkermansia
,
Faecalibacterium
Bacteriodes
Eubacterium,
and
Bifidobacteria
among
typical
NGP
which
exhibit
several
interesting
bioactivities
live
biotherapeutics.
However,
some
extremely
sensitive
oxygen,
such
prausnitzii
.
This
hinders
their
cultivation
large‐scale
production.
Therefore,
it
is
essential
develop
a
strategy
protect
them
during
production,
storage,
colonic
administration.
review,
highlights
key
developed
in
alongside
encapsulation
strategies
used
them.
The
primary
criterion
for
selecting
encapsulating
techniques
feasibility
be
performed
under
strictly
anaerobic
conditions.
Various
processes
selected
according
physical
forms
products,
including
liquid,
gel,
solid
forms,
well
final
shaping
product.
critical
factors
materials
include
biocompatibility,
safety,
effective
oxygen
barrier
properties,
an
optimal
release
profile
gastrointestinal
tract.
review
discusses
protection
aimed
at
improving
survival
thereby
effectiveness
NGPs.
