Skin-whitening effect of hydroxypropyl-β-cyclodextrin/glabridin inclusion complex loaded on a dual thermo/pH-sensitive hydrogel DOI
Yong Chen,

An Liu

Polymer, Journal Year: 2024, Volume and Issue: 316, P. 127788 - 127788

Published: Nov. 16, 2024

Language: Английский

Construction of efficient carotenoid delivery vehicles based on the intestinal epithelial transport pathway: Current applications and future trends DOI
Xuan Peng, Dan Li, Yixiang Liu

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 147, P. 104473 - 104473

Published: March 29, 2024

Language: Английский

Citations

5
Enhanced bioaccessibility of cyclolinopeptides via zein-cyclodextrin nanoparticles: Simulated gastrointestinal digestion and cellular uptake study DOI

Peifang Chen,

Yong Wang, Zizhe Cai

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 471, P. 142841 - 142841

Published: Jan. 9, 2025

Language: Английский

Citations

0
Cyclodextrin-mediated enhancement of gastrointestinal drug delivery: unveiling mucoadhesive and mucopenetrating synergy DOI Creative Commons
Soheil Haddadzadegan,

Ahmad Saleh,

Florina Veider

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

Citations

0
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations DOI Creative Commons
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Intraoral delivery of active pharmaceutical ingredients (API) is an attractive approach to improve their local therapeutic efficacy or enable systemic delivery. It offers several advantages, such as high drug concentration at the intraoral target site and rapid access circulation due vascularization oral cavity, bypassing first‐pass metabolism. However, limitations need be addressed, relatively short residence time formulations applied in cavity salivation, swallowing reflex, tongue movement, well poor membrane permeability of, particular, hydrophilic drugs. Within this review, a comprehensive summary latest strategies formulation approaches field provided, focusing on those pursued by academia industry overcome challenges. An overview provided excipients that are generally recognized safe (GRAS) utilized enhance systems, mucoadhesive materials, enzyme inhibitors, permeation enhancers. Innovative dosage forms outlined, covering solid, semi‐solid, liquid systems aerosols. Future trends, including self‐emulsifying microneedles, situ bioprinting, explored, presenting new opportunities for

Language: Английский

Citations

0
Self-Emulsifying delivery systems for oral administration of exenatide: Hydrophobic ion pairs vs. Dry reverse micelles DOI Creative Commons

Marlene Ramona Schmidt,

M H Ebert,

M. Kiechle

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125711 - 125711

Published: May 1, 2025

Language: Английский

Citations

0
Combination Therapy for Overcoming Multidrug Resistance in Breast Cancer Through Hedgehog Signaling Pathway Regulation DOI Creative Commons
Yujie Liu, Yiliang Yang, Xian Qi

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 572 - 572

Published: April 26, 2025

Background/Objectives: The ineffective delivery of drugs into tumors and the existence multidrug resistance (MDR) are primary causes chemotherapy failure. Downregulation Sonic Hedgehog (Shh) pathway has been shown to reduce P-glycoprotein (P-gp) expression on cell membranes resist MDR. Methods: In this study, we combine cyclopamine (CYP, a potent Shh antagonist) with paclitaxel (PTX, an antitumor drug that can produce MDR) in nano-drug system (CYP NP PTX NP) for treatment drug-resistant breast cancer. Nanoparticles were characterized size, zeta potential, encapsulation efficiency. P-gp expression, nanoparticle accumulation, cytotoxicity, apoptosis evaluated MCF-7 MCF-7/Adr cells. Penetration ability was assessed using 3D multicellular tumor spheroids. Antitumor efficacy biodistribution validated MCF-7/Adr-bearing nude mice models. Results: Our engineered CYP nanoparticles (~200 nm) demonstrated prolonged intratumoral retention, enabling sustained inhibition functional suppression. This size-optimized formulation created favorable microenvironment smaller (~30 nm), facilitating deeper penetration enhanced cellular uptake. Meanwhile, by down-regulating NPs could convert cells PTX-sensitive both cytotoxicity induction through pathway. combination augmented effects Conclusions: offers new therapeutic strategy cancer treatment.

Language: Английский

Citations

0
Cyclodextrin-grafted redox-responsive hydrogel mediated by disulfide bridges for regulated drug delivery DOI Creative Commons
Xin Xu, Jinku Xu,

Zeyuan Sun

et al.

Designed Monomers & Polymers, Journal Year: 2024, Volume and Issue: 27(1), P. 21 - 34

Published: May 30, 2024

In this paper, a novel mono-methacrylated β-cyclodextrin (β-CD) monomer mediated by disulfide bond was synthesized, and then thermal copolymerized with HEMA in the presence of little crosslinker to prepare redox-responsive hydrogel for regulated drug delivery. The structure confirmed FTIR,

Language: Английский

Citations

2
Lipid-lowering effect and oral transport characteristics study of curculigoside DOI Creative Commons
Aiping Wang, Jie Ning,

Lu Zhao

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 2, 2024

Introduction The incidence of metabolic disorders during pregnancy is increasing year by year, with diseases including hypertension and hyperlipidemia. Statins are the primary drugs for treating hyperlipidemia or atherosclerosis, yet some patients remain unresponsive to them, pregnant women prohibited from taking statins. Curculigoside major biologically active natural product present in Curculigo orchioides . Methods In this study, A high-fat mice model was developed study lipid-lowering effect curculigoside. Using intestinal Caco-2 cell monolayer, curculigoside transport properties at two temperatures possible transporters were systemically studied. Results concentrations used experiments have no toxic cells. transfer apical basolateral side strongly influenced temperature. P-glycoprotein, breast cancer resistance protein, efflux crucial components human line Caco-2. can significantly affect contents total cholesterol, triglycerides, high-density lipoprotein low-density cholesterol mice. Discussion potential mechanism offer valuable insights design development hypolipidemic like anti-atherosclerotic also be helpful further pharmacological activity

Language: Английский

Citations

1
Quercetin and doxorubicin co-delivery using β-cyclodextrin nanocarrier overcomes multi-drug resistance in cancer cells via targeting Akt/NF-κB/ABCB1 signaling pathway DOI

Charan Singh Pawar,

N. Rajendra Prasad,

Priya Yadav

et al.

Emergent Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

1
Skin-whitening effect of hydroxypropyl-β-cyclodextrin/glabridin inclusion complex loaded on a dual thermo/pH-sensitive hydrogel DOI
Yong Chen,

An Liu

Polymer, Journal Year: 2024, Volume and Issue: 316, P. 127788 - 127788

Published: Nov. 16, 2024

Language: Английский

Citations

0