Cited by Structural analysis and adjuvant activity of a new polysaccharide from Urtica macrorrhiza

A bioactive polysaccharide derived from Rosa laevigata fruits: Structural properties, antitumor efficacy, and potential mechanisms DOI

Xiaoyang Guo,

Fan Nie,

Haojing Jiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140382 - 140382

Published: Jan. 1, 2025

Language: Английский

Citations

Physicochemical Properties and Cytoprotective Effects on PC12 Cells of Polysaccharides from Belamcanda chinensis (L.) DC. Obtained via a Gradient Ethanol Precipitation Method DOI

Yuanqi Duan,

Jinfeng Sun, Yongkang Xue

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 998 - 998

Published: Feb. 21, 2025

Given that the preparation method of polysaccharides affects functional properties, four types acidic (BCP30-1a, BCP50-1a, BCP70-1a, and BCP90-1a) were prepared using gradient ethanol precipitation method. Then, a series chemical instrumental analysis techniques used to compare structural characteristics morphology. Neuroprotective effects explored OGD/R-induced PC12 cells. The results showed BCP30-1a, BCP90-1a had similar characteristic groups contained both β-glycosidic α-glycosidic bonds. Their molecular weights, in descending order, 198.398 kDa, 184.690 184.556 184.217 respectively. In addition, different proportions glycosidic bonds, namely, Manp-(1→, →5)-Araf-(1→, →3)-Galp (or GalAp)-(1→, →4)-Glcp-(1→ →3,6)-Galp-(1→. BCP30-1a also certain proportion Galp-(1→, each polysaccharide microscopic good thermal stability. Finally, exhibited cytoprotective on cells based OGD/R model. These findings provide novel regulatory strategy for activity BCPs offer scientific evidence supporting application research field ischemic stroke.

Language: Английский

Citations

Salvianolic Acid A From Salvia miltiorrhiza Suppresses Endometrial Carcinoma Progression via CD40‐AKT‐NF‐κB Pathway DOI

Chunhua Zhang, Qing Liu, Lei Bi

et al.

Scandinavian Journal of Immunology, Journal Year: 2025, Volume and Issue: 101(4)

Published: March 25, 2025

We aimed to investigate the effects of Salvianolic acid A (SA), an active ingredient Salvia miltiorrhiza Bunge, on proliferation, metastasis and CD40-AKT-NF-κB signalling pathway in endometrial carcinoma (EC). Human EC cell lines (Ishikawa HEC-1A) were treated with varying concentrations SA, CD40 soluble ligand (sCD40L) or a combination both. Cell viability, invasion migration assessed using MTT, colony formation transwell assays. Flow cytometry was used analyse apoptosis cycle progression. qRT-PCR evaluated mRNA level CD40. The protein expression CD40, p-AKT, p-mTOR, p-p65, p52 via Western blot immunofluorescence. subcutaneous tumour model examine impact SA growth, followed by immunohistochemical analysis Ki-67, p-AKT p-mTOR. treatment reduced migration, while also triggering inducing arrest G0/G1 phase dose-dependent way. These correlated marked downregulation p-p65 expression. Conversely, activation sCD40L promoted malignancy overturned anti-tumour cells. Additionally, suppressed growth xenograft mouse models, along levels Ki67, tissues, which counteracted co-treatment. effectively suppresses progression targeting pathway.

Language: Английский

Citations

Advances and perspectives on isolation, structural characterization, structure-property relationships, and pharmacological mechanisms of tumor immune glucans: A review DOI

Yi Tao, Lisha Shen, Ping Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144621 - 144621

Published: May 1, 2025

Language: Английский

Citations

Structure, anti-cancer properties, and potential mechanism of a biological active polysaccharide from Platycodon grandiflorum DOI

Wenhui Liu, Jiaojiao Zhang,

Yeling Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136153 - 136153

Published: Oct. 1, 2024

Language: Английский

Citations

The Role of the Neurotrophin Network in Skin Squamous Cell Cancer and the Novel Use of the Zebrafish System DOI

Marika Quadri, Elisabetta Palazzo

JID Innovations, Journal Year: 2024, Volume and Issue: 4(5), P. 100295 - 100295

Published: June 5, 2024

Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer. An increasing number cSCCs are associated with dysregulation key molecules that control homeostasis. These observations have increased interest in role neurotrophins and their receptors pathogenesis cSCC. They been demonstrated to a considerable impact on aggressiveness potential cancer by both vitro vivo models. In this context, mouse models classically used dissect proliferation versus differentiation balance, but they some limitations terms time, space, costs. Recently, zebrafish implemented as new tool obtain information regarding invasive capacity metastasis neoplastic cells. By xenotransplantation technique, cSCC cells from patient's biopsy or line can be successfully characterized, without presence genetic manipulation treatments. addition, evaluation immune microenvironment contributes potentially identifying connections homologies humans. review, we retrace neurotrophin network healthy pathological skin, particularly We review how important tools for studying development, growth,

Language: Английский

Citations

Structural analysis and adjuvant activity of a new polysaccharide from Urtica macrorrhiza DOI

Zhongjuan Wang,

Qian Yang, Gang Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137433 - 137433

Published: Nov. 13, 2024

Language: Английский

Citations