Protamine-grafted carboxymethyl chitosan based hydrogel with adhesive and long-term antibacterial properties for hemostasis and skin wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 336, P. 122125 - 122125

Published: April 3, 2024

Language: Английский

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Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 20, 2025

Language: Английский

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A gelatin-chitosan-based film containing berberine hydrochloride/polypyrrole that promotes infectious wound healing through antibacterial and antioxidant properties, and electrical conductivity

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141228 - 141228

Published: Feb. 1, 2025

Language: Английский

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Injectable immunoregulatory hydrogels sequentially drive phenotypic polarization of macrophages for infected wound healing

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 193 - 206

Published: July 20, 2024

Regulating macrophage phenotypes to reconcile the conflict between bacterial suppression and tissue regeneration is ideal for treating infectious skin wounds. Here, an injectable immunoregulatory hydrogel (SrmE20) that sequentially drives phenotypic polarization (M0 M1, then M2) was constructed by integrating anti-inflammatory components proinflammatory solvents.

Language: Английский

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Cohesion Regulation of Polyphenol Cross‐Linked Hydrogel Adhesives: From Intrinsic Cross‐Link to Designs of Temporal Responsiveness

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Polyphenol hydrogels have found widespread application in wound healing, bone repair, drug delivery, and biosensors due to their robust wet adhesion, high ductility, excellent self‐healing ability. However, these often exhibit low intrinsic cohesion, which limits overall adhesive strength. Enhancing cohesion is critical for improving both the adhesion mechanical properties of hydrogels, thereby expanding utility biomedical fields. This review begins by exploring strategies enhance polyphenol hydrogel adhesives, detailing modifications that act individually or synergistically. The importance temporally regulating emphasized accommodate various applications environmental conditions. Finally, this paper discusses remaining challenges regulation outlines prospects future research. It hoped comprehensive will provide new insights into development advanced polyphenolic adhesives contribute design “smart adhesives” increasingly complex needs applications.

Language: Английский

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Multifunctional hydrogel based on polyvinyl alcohol/chitosan/metal polyphenols for facilitating acute and infected wound healing

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101315 - 101315

Published: Oct. 31, 2024

Language: Английский

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Formation of Stable Vascular Networks by 3D Coaxial Printing and Schiff-Based Reaction

Gels, Journal Year: 2024, Volume and Issue: 10(6), P. 366 - 366

Published: May 25, 2024

Vascularized organs hold potential for various applications, such as organ transplantation, drug screening, and pathological model establishment. Nevertheless, the in vitro construction of encounters many challenges, including incorporation intricate vascular networks, regulation blood vessel connectivity, degree endothelialization within inner cavities. Natural polymeric hydrogels, gelatin alginate, have been widely used three-dimensional (3D) bioprinting since 2005. However, a significant disparity exists between mechanical properties hydrogel materials those human soft tissues, necessitating enhancement their through modifications or crosslinking. In this study, we aim to enhance structural stability gelatin-alginate hydrogels by crosslinking molecules with oxidized pullulan (i.e., polysaccharide) alginate calcium chloride (CaCl

Language: Английский

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Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: 15(2), P. 1126 - 1142

Published: Jan. 7, 2025

Recently, photodynamic therapy (PDT) has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis. Unfortunately, activation high mobility group box 1 protein (HMGB1) by PDT triggers innate and adaptive immune responses, which exacerbate skin inflammation. Herein, we combined glycyrrhizic acid (GA), natural anti-inflammatory compound immunomodulator derived from herb Glycyrrhiza uralensis Fisch., with actuated photosensitizer chlorin e6 (Ce6) co-loading them in GA-based lipid nanoparticles coated catechol-modified quaternary chitosan salt (GC NPs/QCS-C). GC NPs/QCS-C exhibited drug loading efficacy, uniform size distribution, an ideal topical adhesive property, enhanced retention penetration psoriasis-like lesions, intracellular uptake epidermal cells compared counterparts. Subsequently, transdermal administration followed near-infrared laser radiation imiquimod-induced mouse model significantly ameliorated psoriasis symptoms, promoted apoptosis hyperproliferative cells, alleviated inflammatory cascade. The significant outcomes were attributed to synergistic effects GA on modulating cell recruitment inhibiting dendritic maturation. Our results demonstrated that bio-adhesive nanosystem combines Ce6 offers chemo-phototherapeutic strategy treatment.

Language: Английский

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Polyvinyl alcohol/chitosan hydrogel based on deep eutectic solvent for promoting methicillin-resistant Staphylococcus aureus-infected wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139916 - 139916

Published: Jan. 1, 2025

Language: Английский

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An adhesive, antibacterial hydrogel wound dressing fabricated by dopamine-grafted oxidized sodium alginate and methacrylated carboxymethyl chitosan incorporated with Cu(II) complex

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 170, P. 214217 - 214217

Published: Feb. 6, 2025

Language: Английский

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