International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136740 - 136740
Published: Oct. 19, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136740 - 136740
Published: Oct. 19, 2024
Language: Английский
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 350, P. 122981 - 122981
Published: Nov. 20, 2024
Language: Английский
Citations
10Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: 9, P. 100729 - 100729
Published: Feb. 24, 2025
Language: Английский
Citations
0Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216581 - 216581
Published: March 11, 2025
Language: Английский
Citations
0Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157272 - 157272
Published: Oct. 1, 2024
Language: Английский
Citations
3Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 919 - 919
Published: July 10, 2024
The encapsulation of sodium sulfobutylether-β-cyclodextrin (SBE-β-CD) is influenced not only by the degree substitution (DS) but also presence strong-bonded water (SBW). Guests compete with SBW for positions within cavity SBE-β-CD. However, correlation between DS and was clear. This study revealed a positive utilizing Karl Fischer titration. mechanism may be attributed to molecular polarizability. To explore impact inside SBE-β-CD different on encapsulation, density functional theory employed. Throughout release process, an increase in enthalpy unfavorable, while entropy favors spontaneous reaction occurrence. For (DS = 2, 3), primary factor, leading retention cavities consequently hindering guest entry. In contrast, 4, 7), situation differs. SBE10-β-CD, influence minimal. aims elucidate relationship SBW, as well effect encapsulation. It crucial comprehensive understanding factors affecting SBE-β-CD, thereby promoting quality control development
Language: Английский
Citations
2Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3824 - 3824
Published: Aug. 12, 2024
Cilostazol is a phosphodiesterase III inhibitor characterized by poor solubility. This limitation can be overcome using drug carrier capable of delivering the to target site. Cyclodextrins are essential as carriers because their outstanding complexation abilities and capacity improve bioavailability. study comprises two stages: The first involves verifying different cyclodextrins towards cilostazol. was accomplished molecular docking simulations (MDS) density functional theory (DFT). Both techniques indicate that largest Sulfobutyl Ether-β-Cyclodextrin forms most stable complex with Additionally, other important parameters described, including binding sites, dominant interactions, thermodynamic such enthalpy, Gibbs free energy, energy solvation. second stage between cilostazol Phosphodiesterse3 (PDE3). conducted simulations, energetic detailed. report, we believe results our predictions will pave way for future development efforts cyclodextrin–cilostazol complexes potential therapeutics.
Language: Английский
Citations
2Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
2International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8476 - 8476
Published: Aug. 3, 2024
Isoamyl 4-methoxycinnamate (IMC) is widely used in various fields because of its exceptional UV-filter properties. However, due to cytotoxicity and anti-microbial degradability, the potential eco-environmental toxicity IMC has become a focus attention. In this study, we propose host-guest supramolecule approach enhance functionality IMC, resulting more environmentally friendly high-performance materials. Sulfobutyl-β-cyclodextrin sodium salt (SBE-β-CD) was as host molecule. IMC-SBE-β-CD supramolecular substances were prepared through "saturated solution method", their properties biosecurity evaluated. Meanwhile, conducted AOS tree evaluation system that surpasses existing approaches based on apoptosis, oxidative stress system, signaling pathways investigate toxicological mechanisms within human hepatoma SMMC-7721 cells model organisms. The aims offer comprehensive analysis cytotoxic effects IMC-SBE-β-CD. Our findings showed had an encapsulation rate 84.45% optimal stability at 30 °C. Further, promoted cell growth reproduction without compromising integrity mitochondria nucleus or disrupting apoptosis-related pathways. Compared biologically safe improved water solubility with UV absorption property maintained. study provides foundation for hydrophobic, low-toxicity organic compounds using cyclodextrins offers valuable insights future research field.
Language: Английский
Citations
0Caderno Pedagógico, Journal Year: 2024, Volume and Issue: 21(10), P. e8665 - e8665
Published: Oct. 4, 2024
Esta revisão destaca as descobertas interdisciplinares emergentes na criação de coad-juvantes terapêuticos para mitigar complicações da quimioterapia oncológica, com foco mucosite gastrointestinal. O estudo discute a aplicação promissora do cinamal-deído, um fitoquímico ativo encontrado em espécies canela como o IFA nano-formulações tratamento efeitos adversos oncológica cuja fisiopatologia base é origem inflamatória. Como plataforma abordagem, utilizamos intestinal induzida por quimioterápicos, que uma reação adver-sa limitante oncológico. A esta se dá pelos achados cinamaldeído detentor atividades biológicas relevantes, envolve suas antioxidantes, anti-inflamatória e moduladoras vias in-tracelulares imunes, podem contribuir redução dos e, portanto, melhor prognóstico oncológica. No entan-to, bem outros bioprodutos, repleto desafios sua aplica-ção clínica, baixa solubilidade aquosa alta volatilidade, pode comprome-ter eficácia. Neste estudo, discutimos estratégias ser aplicadas superar essa limitação, especialmente técnicas escalonáveis viabilidade cadeia produtiva complexação ciclodextrinas incrementar melhorar estabilidade além eficácia terapêutica. Assim, pretende estabelecer literatura, narrativa possa servir aprendizagem acerca desenvolvimento nanocomplexos metabólitos secundários-ciclodextrina, utilizando exemplificação.
Citations
0International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136740 - 136740
Published: Oct. 19, 2024
Language: Английский
Citations
0