Magnetic microscale polymeric nanocomposites in drug delivery: advances and challenges DOI Creative Commons
Kejing Shi, Ali Nokhodchi, Taravat Ghafourian

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: unknown, P. 104276 - 104276

Published: Dec. 1, 2024

Magnetic polymeric nanocomposites are a modern class of materials in which magnetic nanoparticles embedded matrix. This combination responsiveness and tuneable properties bestows versatility on this polymer nanocomposite material, has potentially broad applications drug delivery, imaging, environmental remediation beyond. review covers the uses discussing micelles, liposomes, hydrogels, sponges, mesoporous silica nanoparticles, microrobots, elastomers scaffolds. The focus is role that might be played by as an interface between domains establishment new generation advanced materials.

Language: Английский

A Comprehensive Review of Stimuli-Responsive Smart Polymer Materials—Recent Advances and Future Perspectives DOI Open Access
Alicja Balcerak, Monika Dzwonkowska-Zarzycka, Janina Kabatc

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(17), P. 4255 - 4255

Published: Aug. 28, 2024

Today, smart materials are commonly used in various fields of science and technology, such as medicine, electronics, soft robotics, the chemical industry, automotive field, many others. Smart polymeric hold good promise for future due to their endless possibilities. This group advanced can be sensitive changes or presence chemical, physical, biological stimuli, e.g., light, temperature, pH, magnetic/electric pressure, microorganisms, bacteria, viruses, toxic substances, review concerns newest achievements area materials. The recent advances designing stimuli-responsive polymers described this paper.

Language: Английский

Citations

8
A magnetic/pH dual-sensitive nanocarrier based on biopolymer-grafted mesoporous Fe3O4@SiO2 for imatinib delivery: Fabrication, characterization, and study of the in-vitro release kinetics DOI

Amirmahdi Aslehashemi,

Mahsasadat Miralinaghi, Amir Heydarinasab

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 113970 - 113970

Published: Jan. 1, 2025

Language: Английский

Citations

1
Feruloylation of arabinoxylan enhances the protective effects on probiotic viability and stability in tablet formulations DOI
Huibin Zhang,

Yaqin Hou,

Zhimeng Hu

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123475 - 123475

Published: March 5, 2025

Language: Английский

Citations

1
Applications of Magnetic Nanocomposites and Their Role in Advancing Lateral Flow Assays DOI
Ehsan Sanattalab,

Ezgi Ayni,

Koji Kaya

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(7)

Published: Feb. 1, 2025

Abstract This article explores the wide‐ranging applications of magnetic nanocomposites and their critical role in advancing lateral flow assays (LFAs) as diagnostic tools. We begin by reviewing a diverse array nanomaterials, including plasmonic, polymer, carbon, silica‐based nanocomposites, well notable examples such CoFe₂O₄, quantum dots, lipid‐based nanoparticles, hydrogels, metal–organic frameworks (MOFs), superparamagnetic iron oxide nanoparticles (SPIONs), gold nanorods. Each type nanocomposite is examined for its unique properties significant potential enhancing sensitivity, stability, multifunctionality. These are used across various sectors, medical diagnostics, environmental monitoring, imaging technology, where they contribute to improved signal strength, binding affinity, biocompatibility. The focuses specifically on application LFAs. rely nanoparticles’ interactions with target molecules achieve detection, providing promising platform point‐of‐care diagnostics. integration enhances detection limits, improves precision, reduces response times, making them an invaluable component rapid tests. By embedding into LFAs, researchers clinicians can more reliable accurate results, facilitating early diagnosis ultimately improving patient outcomes. Their LFAs demonstrates applications, from disease real‐time suggesting transformative impact diagnostics beyond.

Language: Английский

Citations

0
Self-Healing Hydrogels with Intrinsic Antioxidant and Antibacterial Properties Based on Oxidized Hydroxybutanoyl Glycan and Quaternized Carboxymethyl Chitosan for pH-Responsive Drug Delivery DOI Creative Commons
Jaepil Jeong, Kyung‐Ho Kim, Eun Kyoung Oh

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 169 - 169

Published: Feb. 26, 2025

In this study, self-healing hydrogels were created using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS), displaying antioxidant antibacterial properties for pH-responsive drug delivery. The structures of the modified polysaccharides confirmed through 1H NMR analysis. Double crosslinking in hydrogel occurred via imine bonds (between aldehyde group OHbG amine QCMCS) ionic interactions carboxyl QCMCS). exhibited improved thermal stability with an increase concentration. OHbG/QCMCS demonstrated high compressive strength, significant swelling, large pore size. Drug release profiles varied between pH 2.0 (96.57%) 7.4 (63.22%). Additionally, displayed effects without compromising polysaccharides’ inherent characteristics. No cytotoxicity was observed any samples. These findings indicate that is a biocompatible stimuli-responsive carrier, potential various pharmaceutical, biomedical, biotechnological applications.

Language: Английский

Citations

0
Traditional Chinese Medicine-Loaded Hydrogels: An Emerging Strategy for the Treatment of Bone Infections DOI Creative Commons
Xin Jin,

Yuchen Yue,

Huaanzi Hu

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 514 - 514

Published: April 14, 2025

Bone infection is a disease that seriously affects patients’ quality of life and physical health. Traditional treatment methods have many drawbacks. Hydrogels loaded with Chinese Medicine (TCM), as an emerging strategy, combine the advantages good biocompatibility hydrogels, adjustable drug release performance, multi-target synergistic TCM, showing great application potential. This article elaborates in detail on research progress hydrogels TCM for bone infections, including classification characteristics mechanism action preparation examples, advantages, challenges prospects faced. The aim to provide new ideas references clinical infections.

Language: Английский

Citations

0
Carbon-Negative Power Generation Using Syngas Produced from CO2-Cofeeding Pyrolysis of Lignocellulosic Biomass DOI
Taewoo Lee, Sangyoon Lee, Yiu Fai Tsang

et al.

Energy, Journal Year: 2025, Volume and Issue: unknown, P. 136215 - 136215

Published: April 1, 2025

Language: Английский

Citations

0
Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway DOI Creative Commons
Yufan Wang, Lei Wang, Hanwen Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

Acanthopanax senticosus is a unique wild resource in Northeast China. Its main active ingredient polysaccharide, which has prominent immunomodulatory effect. In this study, the purified polysaccharide component of leaves(ASPS-A1) with strong activity was isolated by column chromatography, and its structure properties were characterized HPGPC, FT-IR. Results showed that ASPS-A1 mainly composed α- 1,4-D-GalA, 1,5-L-Ara, β- 1,4-D-Gal. RT-qPCR experiments RNA-seq analysis used to study immunoregulatory mechanism ASPS-A1. The results could significantly up-regulate levels cytokines iNOS, IL- 1β, 6, TNF-α activated macrophages through MAPK, NF-κB, Toll-like receptor signaling pathways. Inhibitory further confirmed promotes expression TNF-α, 6 via TLR4 receptor, 1β TLR2 receptor. order identify target ASPS-A1, molecular docking conducted. demonstrated bind both TLR2, forming stable complexes cavities on protein surface hydrogen bonding hydrophobic interaction. scores indicated regulate immune response pathways, particularly interaction TLR4. summary, screened most immunoreactive components disclosed furnished research basis for potential application as natural enhancer.

Language: Английский

Citations

0
Magnetic microscale polymeric nanocomposites in drug delivery: advances and challenges DOI Creative Commons
Kejing Shi, Ali Nokhodchi, Taravat Ghafourian

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: unknown, P. 104276 - 104276

Published: Dec. 1, 2024

Magnetic polymeric nanocomposites are a modern class of materials in which magnetic nanoparticles embedded matrix. This combination responsiveness and tuneable properties bestows versatility on this polymer nanocomposite material, has potentially broad applications drug delivery, imaging, environmental remediation beyond. review covers the uses discussing micelles, liposomes, hydrogels, sponges, mesoporous silica nanoparticles, microrobots, elastomers scaffolds. The focus is role that might be played by as an interface between domains establishment new generation advanced materials.

Language: Английский

Citations

0