MicroRNA expression profiling and potential biomarker exploration in BMSCs of osteoporosis patients based on high-throughput sequencing technology
Abstract
Background
Bone
marrow
mesenchymal
stem
cells
(BMSCs)
are
core
and
their
differentiation
orientation
directly
manipulates
the
ongoing
of
osteoporosis
(OP).
MicroRNAs
(miRNAs)
momentously
characterized
molecular
in
BMSCs.
However,
leading
pattern
trait
miRNAs
OP
remain
vague
mysterious.
Full-scale
research
BMSCs-existed
miRNA
expression
between
normal
conditions
patients
experiencing
is
only
way
for
us
to
pinpoint
effect
miRNA,
making
rationally
effectively
utilize
miRNA.
Objective
This
review
chiefly
lies
exploring,
selecting,
verifying,
confirming
biomarker
by
dissecting
patterns,
which
offer
diagnosis
reference,
monitor
value,
customized
feature
therapy
developing
related
preparation,
emerging
prognosis
indicators.
Methods
We
gathered
miRNA-seq
datasets
from
human
BMSCs
detect
Herein,
we
searched
distinguished
microRNA
levels
BMSCs,
sifted
distinctively
existing
microRNAs,
sought
preferentially
expressed
had
knowledge
target
points
biomarkers,
boosted
our
awareness
role
development
pharmaceutical
preparation
aimed
at
it.
Results
These
manifested
aberrant
variation
matched
control
cases,
they
mainly
draw
upon
Wnt/β-catenin,
MAPK,
Notch
pathways
perform
signal
delivery,
mediating
osteogenesis,
adipogenesis,
balance
these
two
kinds
differentiated
conversion,
proliferation,
migration,
apoptosis,
stemness,
senescence
biological
chondrocytes
osteoclasts.
In
addition,
treatment
based
on
in
vitro
trials
combination
with
animal
models
defined
application
miRNA-linked
therapy.
Conclusion
paper
accorded
proof
as
screening
tools,
confirmation
guidance,
means,
prediction
indicators
OP,
paved
road
clinical
practice,
pushed
personalized
remedies
that
break
through
regular
remedies.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 31, 2024
Language: Английский