Characterization and application of fluorescent hydrogel films with superior mechanical properties in detecting iron(Ⅲ) ions and ferroptosis in oral cancer

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 14, 2025

A one-step hydrothermal method was applied to prepare carbon dots (CDs) with superior fluorescence properties using chitosan as a source. The as-prepared were then grafted onto sodium alginate-gelatin hydrogel film form fluorescent (FHGF), emitting at 450 nm under excitation of 350 light. In comparison the CDs, intensity this maintained over 90.0% and luminescence position remained basically unchanged, caused by unchanged surface light-emitting structure due existence electrostatic repulsion between CDs hydrogel. Moreover, tensile-stress 1.0 wt.% increased 200% 10.3 Mpa, strain from 117% 153%. above experimental results are attributed hydrogen bonding analyses FT-IR spectra. Interestingly, Fe3+ exerted great quenching effect on in concentration range 0-1.8 μM. can be used recyclically detect solution detection limit low 0.043 word, work demonstrated an enormous potential fabricating mechanical proposed new platform for Fe3+. view promising capacity, also oral bacteria surveillance semi-quantification ferroptosis cancer.

Language: Английский

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Preparation of Antibacterial Nanofiber Nanocomposites Based on Bacterial Cellulose

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 14, 2025

Language: Английский

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Effect of Carboxymethyl chitosan-sodium alginate hydrogel loaded with Astragalus membranaceus-Panax notoginseng on wound healing in rats

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Skin wound healing is a complex physiological process that involves many different cell types and signaling molecules. In traditional Chinese medicine, A. membranaceus Panax notoginseng are commonly used together for the treatment of injury their significant efficacy. The application new materials may make -P. (AP) play better curative effect. this study, we fabricated Carboxymethyl chitosan-Sodium alginate hydrogel loaded with extract Astragalus - P. (APCS), which showed favorable stability, biocompatibility, ability to rapidly release drugs. Cell culture experiments demonstrated APCS dramatically increased fibroblast proliferation, migration, differentiation into myofibroblast. vivo on SD rats hydrogels significantly accelerated skin healing, reduced inflammatory response, enhanced formation blood vessels, granulation tissues, collagen fibers, promoted re-epithelialization at site. Increased expression catalase, VEGF, PGP9.5 tissue indicated inhibited oxidative stress vascular neuronal regeneration. summary, displayed great potential as dressing achieving satisfactory full-thickness wounds.

Language: Английский

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Preparation and characterization of multifunctional cellulose-based materials modified by hyperbranched polyamide

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140641 - 140641

Published: Feb. 3, 2025

Language: Английский

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The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 562 - 562

Published: Feb. 24, 2025

Background/Objectives. Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, re-epithelialization, hinder healing process in chronic wounds. Many these processes are dependent on their interaction with copper. We hypothesized that targeted delivery copper ions to wound bed would enhance healing. Methods. Wound dressings impregnated oxide microparticles were designed ensure controlled release ions. The efficacy was evaluated using non-infected models, diabetic mouse models compared against control silver dressings. Outcome measures included closure rates, epidermal skin quality assessed histopathological examination, gene expression profiling. Clinical applications through diverse case studies trials involving management. Results. Copper significantly accelerated enhanced angiogenesis Histopathological analyses revealed faster granulation tissue formation, regeneration, neovascularization. Gene showed upregulation critical angiogenic factors VEGF HIF-1α. Investigations clinical observations corroborated improved across various types, Conclusions. is essential for healing, copper-impregnated provide promising solution By enhancing go beyond antimicrobial action, offering cost-effective innovative alternative conventional therapies. represent transformative advancement addressing challenges care.

Language: Английский

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Mineralized cellulose nanofibers reinforced bioactive hydrogel remodels the osteogenic and angiogenic microenvironment for enhancing bone regeneration

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123480 - 123480

Published: March 8, 2025

Language: Английский

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Bioactive Bacterial Nanocellulose Membranes for Non-Surgical Debridement and Infection Prevention in Burn Wound Healing

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100762 - 100762

Published: March 1, 2025

Language: Английский

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